Patent US4831018A successfully refreshed from Google Patents.
US4831018A
Expired / Lapsed
US
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Polyene antibiotic emulsion formulation
Assignee: SmithKline Beecham Corp
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Filing: 1987-03-25
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Granted: 1989-05-16
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Expires: 2007-03-25
Abstract
Abstract A polyene antibiotic emulsion formulation comprising a therapeutically effective amount of the antibiotic incorporated into an oil-in-water emulsion, and a method of treating an active infection in an animal caused by a microorganism with sterols in its cell membrane by parenterally administering the emulsion formulation to such animal.
Inventors
- 👤 Richard L. Kirsh
- 👤 Louis J. Ravin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:54
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/10; A61K9/107; A61K9/1075; C; C07; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
52 words
A package comprising a container of a pharmaceutical formulation suitable for admixture to a parenterally administerable oil-in-water emulsion which formulation includes amphotericin B and dimethylacetamide in an amount sufficient to incorporate the amphotericin B into the oil-in-water emulsion upon admixture, and a second container of an oil-in-water emulsion suitable for parenteral administration.
Claim 2
Dependent Claim
52 words
A package comprising a container of a pharmaceutical formulation suitable for admixture to a parenterally administerable oil-in-water emulsion which formulation includes amphotericin B and dimethylacetamide in an amount sufficient to incorporate the amphotericin B into the oil-in-water emulsion upon admixture, and a second container of an oil-in-water emulsion suitable for parenteral administration.
Claim 3
Dependent Claim
37 words
A package of claim 2 wherein the container of the pharmaceutical formulation of amphotericin B and dimethylacetamide includes deoxycholic acid in an amount sufficient to facilitate incorporation of the amphotericin B into the oil-in-water emulsion upon admixture.
Claim 4
Dependent Claim
47 words
A package comprising a container of amphotericin B suitable for parenteral administration, a second container of dimethylacetamide suitable for parenteral administration in an amount sufficient to incorporate amphotericin B into an oil-in-water emulsion upon admixture, and a third container of an oil-in-water emulsion suitable for parenteral administration.
Claim 5
Dependent Claim
47 words
A package comprising a container of amphotericin B suitable for parenteral administration, a second container of dimethylacetamide suitable for parenteral administration in an amount sufficient to incorporate amphotericin B into an oil-in-water emulsion upon admixture, and a third container of an oil-in-water emulsion suitable for parenteral administration.
Claim 6
Dependent Claim
29 words
A package of claim 3 wherein the second container of dimethylacetaide includes deoxycholic acid in an amount sufficient to facilitate incorporation of the amphotericin B into the oil-in-water emulsion.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-05-15 | 1992-11-14 | 1993-05-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-05-15 | 1996-11-14 | 1997-05-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-05-15 | 2000-11-14 | 2001-05-16 | $7700.00 | Window Closed / Lapsed |