US4707470A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Polyene antibiotic emulsion formulation
Assignee: SmithKline Beecham Corp
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Filing: 1985-05-17
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Granted: 1987-11-17
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Expires: 2005-05-17
Abstract
Abstract A polyene antibiotic emulsion formulation comprising a therapeutically effective amount of the antibiotic incorporated into an oil-in-water emulsion, and a method of treating an active infection in an animal caused by a microorganism with sterols in its cell membrane by parenterally administering the emulsion formulation to such animal.
Inventors
- 👤 Richard L. Kirsh
- 👤 Louis J. Ravin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 16:21
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K9/00; A61K9/10; A61K9/107; A61K9/1075; A61P; A61P31/00; A61P31/04; C; C07; C07H; C07H17/00; C07H17/04; C07H17/08
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
32 words
A pharmaceutical formulation suitable for admixture to a parenterally administerable oil-in-water emulsion, comprising amphotericin B and dimethylacetamide in an amount sufficient to incorporate the amphotericin B into the oil-in-water emulsion upon admixture.
Claim 2
Dependent Claim
32 words
A pharmaceutical formulation suitable for admixture to a parenterally administerable oil-in-water emulsion, comprising amphotericin B and dimethylacetamide in an amount sufficient to incorporate the amphotericin B into the oil-in-water emulsion upon admixture.
Claim 3
Dependent Claim
26 words
A pharmaceutical formulation of claim 1 containing deoxycholic acid in an amount sufficient to facilitate incorporation of the amphotericin B into the oil-in-water emulsion upon admixture.
Claim 4
Dependent Claim
24 words
A polyene antibiotic emulsion formulation which comprises a therapeutically effective amount of a polyene antibiotic incorporated into an oil-in-water emulsion suitable for parenteral administration.
Claim 5
Dependent Claim
24 words
A polyene antibiotic emulsion formulation which comprises a therapeutically effective amount of a polyene antibiotic incorporated into an oil-in-water emulsion suitable for parenteral administration.
Claim 6
Dependent Claim
26 words
The formulation according to claim 3 wherein the oil or fat is sesame seed oil, soybean oil, corn oil, peanut oil, isopropyl myristate or glyceryl tripelargonate.
Claim 7
Dependent Claim
24 words
The formulation according to claim 4 wherein the amount of oil or fat in the oil-in-water emulsion is from about 5 to about 40%.
Claim 8
Dependent Claim
20 words
The formulation according to claim 5 wherein the amount of oil or fat is from about 10 to about 20%.
Claim 9
Dependent Claim
12 words
The formulation according to claim 6 wherein the emulsion is Intralipid® 20%.
Claim 10
Dependent Claim
13 words
The formulation according to claim 7 wherein the polyene antibiotic is amphotericin B.
Claim 11
Dependent Claim
12 words
The formulation according to claim 7 wherein the polyene antibiotic is nystatin.
Claim 12
Dependent Claim
24 words
The formulation according to claim 3 wherein the polyene antibiotic is a tetraene, a methylpentaene, a carbonylpentaene, a hexaene, a carbonylhexaene, or a heptaene.
Claim 13
Dependent Claim
37 words
The formulation according to claim 10 wherein the tetraene is nystatin, the pentaene is aliomycin, the methylpentaene is filipin, the carbonylpentaene is mycoticin, the hexaene is cryptocidine, the carbonylhexaene is dermostatin, or the heptaene is amphotericin B.
Claim 14
Dependent Claim
13 words
The formulation according to claim 11 wherein the polyene antibiotic is amphotericin B.
Claim 15
Dependent Claim
12 words
The formulation according to claim 11 wherein the polyene antibiotic is nystatin.
Claim 16
Independent Claim
50 words
A method of treating an active infection in an animal, wherein said infection is caused by a microorganism which has sterols in its cell membrane, which comprises parenterally administering to such animal a polyene antibiotic emulsion formulation containing a therapeutically effective amount of said antibiotic incorporated into an oil-in-water emulsion.
Claim 17
Independent Claim
50 words
A method of treating an active infection in an animal, wherein said infection is caused by a microorganism which has sterols in its cell membrane, which comprises parenterally administering to such animal a polyene antibiotic emulsion formulation containing a therapeutically effective amount of said antibiotic incorporated into an oil-in-water emulsion.
Claim 18
Dependent Claim
19 words
The method of claim 14 wherein the total daily doage given is from about 0.25 mg/kg to 9 mg/kg.
Claim 19
Dependent Claim
20 words
The method of claim 14 wherein the infection is caused by any Candida species, any Aspergillus species or Torulopsis glabrata.
Claim 20
Dependent Claim
13 words
The method of claim 16 wherein the infection is caused by C. albicans.
Claim 21
Dependent Claim
25 words
The method of claim 14 wherein the oil or fat is sesame seed oil, soybean oil, corn oil, peanut oil, isopropyl myristate, or glyceryl tripelargonate.
Claim 22
Dependent Claim
23 words
The method of claim 18 wherein the amount of oil or fat in the oil-in-water emulsion is from about 5 to about 40%.
Claim 23
Dependent Claim
19 words
The method of claim 19 wherein the amount of oil or fat is from about 10 to about 20%.
Claim 24
Dependent Claim
11 words
The method of claim 20 wherein the emulsion is Intalipid® 20%.
Claim 25
Dependent Claim
12 words
The method of claim 21 wherein the polyene antibiotic is amphotericin B.
Claim 26
Dependent Claim
13 words
The method of claim 22 wherein the infection is caused by C. albicans.
Claim 27
Dependent Claim
11 words
The method of claim 21 wherein the polyene antibiotic is nystatin.
Claim 28
Dependent Claim
13 words
The method of claim 24 wherein the infection is caused by C. albicans.
Claim 29
Dependent Claim
26 words
The method according to claim 14 wherein the polyene antibiotic is a tetraene, a pentaene, a methylpentaene, a carbonylpentaene, a hexaene, a carbonylhexaene, or a heptaene.
Claim 30
Dependent Claim
37 words
The method according to claim 26 wherein the tetraene is nystatin, the pentaene is aliomycin, the methylpentaene is filipin, the carbonylpentaene is mycoticin, the hexaene is cryptocidine, the carbonylhexaene is dermostatin, or the heptaene is amphotericin B.
Claim 31
Dependent Claim
12 words
The method of claim 27 wherein the polyene antibiotic is amphotericin B.
Claim 32
Dependent Claim
11 words
The method of claim 27 wherein the polyene antibiotic is nystatin.
References Cited (Backward Citations)
US3651218A
Cited
US4148891A
Cited
US4073943A
Cited
US4025620A
Cited
US4168308A
Cited
GB2116425A
Cited
US4542020A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-16 | 1991-05-18 | 1991-11-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-16 | 1995-05-18 | 1995-11-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-16 | 1999-05-18 | 1999-11-17 | $7700.00 | Window Closed / Lapsed |