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US4826810A
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System and method for treating animal body tissues to improve the dietary fuel processing capabilities thereof
Assignee: Individual
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Filing: 1987-03-19
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Granted: 1989-05-02
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Expires: 2007-03-19
Abstract
Abstract A system and method for treating an animal subject having predetermined body tissues characterized by abnormal or impaired dietary fuel processing capabilities. A dietary fuel of preselected type and quantity is administered to the subject to produce in the blood supply to these body tissues a substantially elevated carbohydrate concentration during a time period following such administration. During at least a portion of the time period of such elevated carbohydrate concentration, insulin is injected into the subject in accordance with a prearranged insulin concentration versus time function. This function is independent of the magnitude of the carbohydrate concentration in the blood stream, i.e. the carbohydrate concentration does not have to be measured since it is not used to control the insulin injection. The insulin injection function produces a rapid increase in the free insulin concentration in the blood supply to the involved body tissues and is preferably a prearranged series of spaced insulin pulses that produce a series of peaks in the free insulin concentration in the blood supply to the target tissues and a continuously rising interpeak value of free insulin concentration. The coincidence of the elevated carbohydrate concentration and rapid increase in free insulin concentration thereby produces a functional improvement in the dietary fuel processing capabilities of the involved body tissues. A computer controlled insulin pumping system functions under program control to provide the series of insulin pulses.
Inventors
- 👤 Thomas T. Aoki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 08:20
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
111 words
A method for treating a human subject having predetermined body tissues characterized by abnormal or impaired dietary fuel processing capability, comprising: (a) administering carbohydrate to said subject to produce in the blood supply to said body tissues a substantially elevated carbohydrate concentration during a time period following such administration; and (b) infusing insulin into said subject during at least a portion of said time period in a prearranged series of pulses separated by prearranged time periods, thereby producing in the blood supply to said body tissues a series of peaks in the free insulin concentration, said prearranged time periods selected to produce successively increasing free insulin concentration minima between said peaks.
Claim 2
Independent Claim
111 words
A method for treating a human subject having predetermined body tissues characterized by abnormal or impaired dietary fuel processing capability, comprising: (a) administering carbohydrate to said subject to produce in the blood supply to said body tissues a substantially elevated carbohydrate concentration during a time period following such administration; and (b) infusing insulin into said subject during at least a portion of said time period in a prearranged series of pulses separated by prearranged time periods, thereby producing in the blood supply to said body tissues a series of peaks in the free insulin concentration, said prearranged time periods selected to produce successively increasing free insulin concentration minima between said peaks.
Claim 3
Dependent Claim
93 words
The method of claim 1, wherein step (b) is carried out during a first prearranged time period, and said method further comprises: (c) infusing insulin into said subject during a second time period in a series of pulses of lesser magnitude than the pulses during said first time period to produce oscillations in the free insulin concentration in the blood supply to said body tissues, said second time period being delayed from said first time period by an amount of time such that said free insulin concentration has returned to a baseline level.
Claim 4
Independent Claim
145 words
A method for treating a human subject having predetermined body tissues with abnormal or impaired dietary fuel processing capability to produce a functional improvement in such dietary fuel processing capability, comprising: (a) infusing a first pulse of insulin into said subject at a prearranged time period following ingestion of a normal to high carbohydrate concentration meal to produce in the blood supply to said body tissues a rapid increase in the free insulin concentration coinciding with an elevated carbohydrate concentration but independent of the magnitude of said carbohydrate concentration; and (b) infusing a prearranged series of additional pulses of insulin into said subject, each of said additional pulses being spaced in time relative to said first pulse and to each other to produce a series of peaks in said free insulin concentration in said blood supply with successively increasing free insulin concentration minima between peaks.
Claim 5
Independent Claim
145 words
A method for treating a human subject having predetermined body tissues with abnormal or impaired dietary fuel processing capability to produce a functional improvement in such dietary fuel processing capability, comprising: (a) infusing a first pulse of insulin into said subject at a prearranged time period following ingestion of a normal to high carbohydrate concentration meal to produce in the blood supply to said body tissues a rapid increase in the free insulin concentration coinciding with an elevated carbohydrate concentration but independent of the magnitude of said carbohydrate concentration; and (b) infusing a prearranged series of additional pulses of insulin into said subject, each of said additional pulses being spaced in time relative to said first pulse and to each other to produce a series of peaks in said free insulin concentration in said blood supply with successively increasing free insulin concentration minima between peaks.
Claim 6
Dependent Claim
21 words
The method of claim 1 wherein said pulses of step (b) are administered over a period of up to three hours.
Claim 7
Dependent Claim
21 words
The method of claim 1 wherein said pulses of step (b) are administered over a period of 6 to 180 minutes.
Claim 8
Dependent Claim
42 words
The method of claim 2 wherein said pulses of step (c) are arranged to produce oscillation in said free insulin concentration about a baseline concentration and thereby maintain the dietary carbohydrate processing capabilities of said subject's body tissues in an active state.
Claim 9
Dependent Claim
15 words
The method of claim 2 wherein step (c) is continued until step (a) is repeated.
Claim 10
Independent Claim
21 words
The method of any of claims 1, 2, 3, 4, 5, 6, or 7 wherein steps (a) and (b) are coincident.
Claim 11
Independent Claim
27 words
The method of any of claims 1, 2, 3, 4, 5, 6, or 7 wherein said activating step is performed from 2 to 8 times a day.
Claim 12
Independent Claim
22 words
The method of any of claims 1, 2, 3, 4, 5, 6, or 7 wherein step (a) is performed by ingesting carbohydrates.
Claim 13
Independent Claim
26 words
The method of any of claims 1, 2, 3, 4, 5, 6, or 7 wherein step (a) is performed by infusing carbohydrate into said subject's bloodstream.
Claim 14
Independent Claim
27 words
The method of any of claims 1, 2, 3, 4, 5, 6, or 7 wherein step (a) is performed by administering from 10-100 g of dietary carbohydrate.
Claim 15
Dependent Claim
22 words
The method of any of claim 1, 4, or 5 wherein said pulses each fall within the range of about 0.01-0.05 U/kg.
Claim 16
Independent Claim
22 words
The method of any of claims 1, 4, or 5 wherein said pulses each fall within the range of about 0.02-0.04 U/kg.
Claim 17
Independent Claim
20 words
The method of any of claims 1, 4, or 5 wherein said pulses are administered every six to thirty minutes.
Claim 18
Independent Claim
25 words
The method of any of claims 2, 6, or 7 wherein said pulses of step (c) each fall within the range of about 0.001-0.02 U/kg.
Claim 19
Independent Claim
23 words
The method of any of claims 2, 6, or 7 wherein said pulses of step (c) are administered every two to ninety minutes.
Claim 20
Dependent Claim
19 words
The method of claim 1 wherein said pulses are on the average within the range of about 0.01-0.05 U/kg.
Claim 21
Dependent Claim
19 words
The method of claim 1 wherein said pulses are on the average within the range of about 0.02-0.04 U/kg.
Claim 22
Dependent Claim
15 words
The method of claim 1 wherein said pulses are administered every six to thirty minutes.
Claim 23
Dependent Claim
87 words
The method of claim 2 wherein said pulses of step (b) are each within the ragne of about 0.01-0.05 U/kg; said pulses of step (c) are each within the range of about 0.001-0.02 U/kg; said pulses of step (b) are administered every six to thirty minutes; said pulses of step (c) are administered every two to ninety minutes; step (a) is performed from two to eight times a day by administering 10-100 g of dietary carbohydrate; and step (b) is performed in coincident manner with step (a).
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| 3.5 Years (Year 4) | 1992-05-01 | 1992-10-31 | 1993-05-02 | $2000.00 | Window Closed / Lapsed |
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