US4786495A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic agents
Assignee: Boots Co PLC
•
Filing: 1986-10-02
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Granted: 1988-11-22
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Expires: 2006-10-02
Abstract
Abstract A pharmaceutical composition comprising the analgesic and anti-inflammatory agent 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and certain esters of natural vegetable oil fatty acids, provides a rapid release of 2-(2-fluoro-4-biphenylyl)propionic acid into the body, and hence a very rapid analgesic and anti-inflammatory effect.
Inventors
- 👤 Graham Bird
- 👤 Alan Smith
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 19:43
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/4841; A61K9/4858; A61K31/00; A61K31/185; A61K31/19; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 34
Claim 1
Independent Claim
108 words
A method of treating inflammation in humans and animals which comprises orally administering to a human or animal in need thereof an anti-inflammatory effective amount of 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and an amount of excipient sufficient to produce a rapid release of the active agent into the human or animal, said excipient being one suitable for formulating solid orally administerable pharmaceutical compositions and further being a fatty acid ester which comprises one or more polyol esters and glycerides of natural vegetable oil fatty acids, said excipient having a melting point in the range of 30°-50° C. and an HLB value of at least 10.
Claim 2
Independent Claim
108 words
A method of treating inflammation in humans and animals which comprises orally administering to a human or animal in need thereof an anti-inflammatory effective amount of 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and an amount of excipient sufficient to produce a rapid release of the active agent into the human or animal, said excipient being one suitable for formulating solid orally administerable pharmaceutical compositions and further being a fatty acid ester which comprises one or more polyol esters and glycerides of natural vegetable oil fatty acids, said excipient having a melting point in the range of 30°-50° C. and an HLB value of at least 10.
Claim 3
Dependent Claim
18 words
A method according to claim 6 wherein the fatty acid esters have HLB value of at least 12.
Claim 4
Dependent Claim
19 words
A method according to claim 2 wherein the fatty acid esters have a HLB value of at least 14.
Claim 5
Dependent Claim
21 words
A method according to claim 3 wherein the fatty acid esters have a melting point in the range of 33°-46° C.
Claim 6
Dependent Claim
19 words
A method according to claim 4 wherein the natural vegetable oil fatty acids have 8 to 22 carbon atoms.
Claim 7
Dependent Claim
15 words
A method according to claim 1 wherein the polyol esters comprise esters of polyethylene glycol.
Claim 8
Dependent Claim
21 words
A method according to claim 1 wherein 2-(2-fluoro-4-biphenylyl)propionic acid comprises up to 40% by weight of the 2-(2-fluoro-4-biphenylyl)propionic acid and excipient.
Claim 9
Dependent Claim
15 words
A method according to claim 1 wherein 2-(2-fluoro-4-biphenylyl)propionic acid is in the form of flurbiprofen.
Claim 10
Dependent Claim
18 words
A method according to claim 1 wherein the 2-(2-fluoro-4-biphenylyl)propionic acid is in the form of the sodium salt.
Claim 11
Dependent Claim
21 words
A method according to claim 1 in which a hard gelatin capsule comprising said 2-(2-fluoro-4-biphenylyl)propionic acid and said excipient is administered.
Claim 12
Independent Claim
108 words
A method of effecting analgesia in humans and animals which comprises orally administering to a human or animal in need thereof an analgesically effective amount of 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and an amount of excipient sufficient to produce a rapid release of the active agent into the human or animal, said excipient being one suitable for formulating solid orally administerable pharmaceutical compositions and further being a fatty acid ester which comprises one or more polyol esters and glycerides of natural vegetable oil fatty acids, said excipient having a melting point in the range of 30°-50° C. and an HLB value of at least 10.
Claim 13
Independent Claim
108 words
A method of effecting analgesia in humans and animals which comprises orally administering to a human or animal in need thereof an analgesically effective amount of 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and an amount of excipient sufficient to produce a rapid release of the active agent into the human or animal, said excipient being one suitable for formulating solid orally administerable pharmaceutical compositions and further being a fatty acid ester which comprises one or more polyol esters and glycerides of natural vegetable oil fatty acids, said excipient having a melting point in the range of 30°-50° C. and an HLB value of at least 10.
Claim 14
Dependent Claim
19 words
A method according to claim 11 wherein the fatty acid esters have a HLB value of at least 12.
Claim 15
Dependent Claim
19 words
A method according to claim 12 wherein the fatty acid esters have a HLB value of at least 14.
Claim 16
Dependent Claim
21 words
A method according to claim 13 wherein the fatty acid esters have a melting point in the range of 33°-46° C.
Claim 17
Dependent Claim
19 words
A method according to claim 14 wherein the natural vegetable oil fatty acids have 8 to 22 carbon atoms.
Claim 18
Dependent Claim
15 words
A method according to claim 11 wherein the polyol esters comprise esters of polyethylene glycol.
Claim 19
Dependent Claim
21 words
A method according to claim 11 wherein 2-(2-fluoro-4-biphenylyl)propionic acid comprises up to 40% by weight of the 2-(2-fluoro-4-biphenylyl)propionic acid and excipient.
Claim 20
Dependent Claim
15 words
A method according to claim 11 wherein 2-(2-fluoro-4-biphenylyl)propionic acid is in the form of flurbiprofen.
Claim 21
Dependent Claim
18 words
A method according to claim 11 wherein the 2-(2-fluoro-4-biphenylyl)propionic acid is in the form of the sodium salt.
Claim 22
Dependent Claim
21 words
A method according to claim 11 in which a hard gelatin capsule comprising said 2-(2-fluoro-4-biphenylyl)propionic acid and said excipient is administered.
Claim 23
Dependent Claim
103 words
A solid pharmaceutical composition in oral administration form useful for treating pain, inflammation and fever in humans and animals, which comprises 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and an amount of excipient sufficient to produce a rapid release of the active agent into the human or animal, said excipient being one suitable for formulating solid orally administerable pharmaceutical compositions and further being a fatty acid ester which comprises one or more polyol esters and glycerides of natural vegetable oil fatty acids, said excipient having a melting point in the range of 30°-50° C. and an HLB value of at least 10.
Claim 24
Dependent Claim
103 words
A solid pharmaceutical composition in oral administration form useful for treating pain, inflammation and fever in humans and animals, which comprises 2-(2-fluoro-4-biphenylyl)propionic acid or a pharmaceutically acceptable salt thereof and an amount of excipient sufficient to produce a rapid release of the active agent into the human or animal, said excipient being one suitable for formulating solid orally administerable pharmaceutical compositions and further being a fatty acid ester which comprises one or more polyol esters and glycerides of natural vegetable oil fatty acids, said excipient having a melting point in the range of 30°-50° C. and an HLB value of at least 10.
Claim 25
Dependent Claim
20 words
A pharmaceutical composition according to claim 21 wherein the fatty acid esters has a HLB value of at least 12.
Claim 26
Dependent Claim
20 words
A pharmaceutical composition according to claim 22 wherein the fatty acid esters have a HLB value of at least 14.
Claim 27
Dependent Claim
22 words
A pharmaceutical composition according to claim 23 wherein the fatty acid esters have a melting point in the range of 33°-46° C.
Claim 28
Dependent Claim
20 words
A pharmaceutical composition according to claim 24 wherein the natural vegetable oil fatty acids have 8 to 22 carbon atoms.
Claim 29
Dependent Claim
16 words
A pharmaceutical composition according to claim 21 wherein the polyol esters comprise esters of polyethylene glycol.
Claim 30
Dependent Claim
19 words
A pharmaceutical composition according to claim 21 wherein 2-(2-fluoro-4-biphenylyl)propionic acid comprises up to 40% by weight of the composition.
Claim 31
Dependent Claim
16 words
A pharmaceutical composition according to claim 21 wherein 2-(2-fluoro-4-biphenylyl)propionic acid is in the form of flurbiprofen.
Claim 32
Dependent Claim
19 words
A pharmaceutical composition according to claim 21 wherein the 2-(2-fluoro-4-biphenylyl)propionic acid is in the form of the sodium salt.
Claim 33
Dependent Claim
15 words
A pharmaceutical composition according to claim 21 in the form of a hard gelatin capsule.
Claim 34
Dependent Claim
40 words
A process for making a pharmaceutical composition of claim 21 in which 2-(2-fluoro-4-biphenylyl)propionic acid is added to the fatty acid esters excipient in molten form with stirring to form a homogeneous solution or dispersion and allowing the composition to solidify.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-11-22 | 1992-05-23 | 1992-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-11-22 | 1996-05-23 | 1996-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-11-22 | 2000-05-23 | 2000-11-22 | $7700.00 | Window Closed / Lapsed |