US4388307A
Expired / Lapsed
US
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Galenical compositions
Assignee: Novartis AG
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Filing: 1982-02-09
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Granted: 1983-06-14
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Expires: 2002-02-09
Abstract
Abstract The present invention provides a pharmaceutical composition comprising a pharmacologically active monocyclic peptide and a carrier comprising at least one of the following components: (a) a non-ionic ester of a triglyceride and a polyalkylene polyol, (b) a saturated fatty acid triglyceride, and (c) a mono- or di-glyceride having improved physical and absorption properties.
Inventors
- 👤 Thomas Cavanak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 01:17
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K38/00; A61K38/04; A61K38/12; A61K38/13; A61K9/00; A61K9/0012; A61K9/0019; A61K9/10; A61K9/127; A61K9/1274; A61K9/48; A61K9/4841; A61K9/4858; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/27
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
94 words
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of a cyclosporin and a carrier comprising the following components: (a) a trans-esterification product of a natural vegetable oil triglyceride and a polyalkylene polyol; (b) a vegetable oil; and (c) ethanol; whrein the ratio of component (a) to cyclosporin is 10:0.2 to 10 parts by weight; the amount of component (b) is 35 to 60% by weight based on the total weight of the composition, and the amount of component (c) is 1 to 20% by weight based on the total weight of the composition.
Claim 2
Dependent Claim
94 words
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of a cyclosporin and a carrier comprising the following components: (a) a trans-esterification product of a natural vegetable oil triglyceride and a polyalkylene polyol; (b) a vegetable oil; and (c) ethanol; whrein the ratio of component (a) to cyclosporin is 10:0.2 to 10 parts by weight; the amount of component (b) is 35 to 60% by weight based on the total weight of the composition, and the amount of component (c) is 1 to 20% by weight based on the total weight of the composition.
Claim 3
Dependent Claim
11 words
Composition according to claim 1, wherein the cyclosporin is cyclosporin A.
Claim 4
Dependent Claim
11 words
Composition according to claim 1, wherein the cyclosporin is dihydrocyclosporin C.
Claim 5
Dependent Claim
11 words
Composition according to claim 1, wherein the cyclosporin is cyclosporin D.
Claim 6
Dependent Claim
11 words
Composition according to claim 1, wherein the cyclosporin is dihydrocyclosporin D.
Claim 7
Dependent Claim
35 words
Composition according to claim 1, wherein component (a) is a trans-esterification product of two molar parts of a natural vegetable oil triglyceride and one molar part of a polyethylene glycol of MW 200 to 800.
Claim 8
Dependent Claim
13 words
Composition according to claim 6, wherein the natural vegetable oil is kernel oil.
Claim 9
Dependent Claim
36 words
Composition according to claim 7, wherein component (a) is a polyoxyethylated kernel oil mixture, having a density of D 20 =0.940-0.965, an acid number <2, an iodine number=60-90, a saponification number=145-175 and a hydrophilic-lipophilic balance (H.L.B.)=4.
Claim 10
Dependent Claim
14 words
Composition according to claim 1, wherein component (b) is olive oil or corn oil.
Claim 11
Dependent Claim
11 words
Composition according to claim 9, wherein component (b) is olive oil.
Claim 12
Dependent Claim
20 words
Composition according to claim 1, wherein the ratio of component (a) to cyclosporin is 10:1 to 10 parts by weight.
Claim 13
Dependent Claim
15 words
Composition according to claim 11, wherein the ratio is 10:1 to 7 parts by weight.
Claim 14
Dependent Claim
30 words
Composition according to claim 1, wherein components (b) and (c) together are present in an amount of up to 60% by weight based on the total weight of the composition.
Claim 15
Dependent Claim
11 words
Composition according to claim 1, formulated as solution for oral administration.
Claim 16
Dependent Claim
94 words
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of a cyclosporin and a carrier comprising the following components: (a) a trans-esterification product of a hydrogenated vegetable oil triglyceride and a polyalkylene polyol; (b) a vegetable oil; and (c) ethanol; wherein the ratio of component (a) to cyclosporin is 10:0.2 to 10 parts by weight; the amount of component (b) is 35 to 60% by weight based on the total weight of the composition, and the amount of component (c) is 1 to 20% by weight based on the total weight of the composition.
Claim 17
Dependent Claim
94 words
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of a cyclosporin and a carrier comprising the following components: (a) a trans-esterification product of a hydrogenated vegetable oil triglyceride and a polyalkylene polyol; (b) a vegetable oil; and (c) ethanol; wherein the ratio of component (a) to cyclosporin is 10:0.2 to 10 parts by weight; the amount of component (b) is 35 to 60% by weight based on the total weight of the composition, and the amount of component (c) is 1 to 20% by weight based on the total weight of the composition.
References Cited (Backward Citations)
US3288824A
Cited
US3881012A
Cited
FR2253531A1
Cited
US4073920A
Cited
FR2330387A1
Cited
US4108985A
Cited
FR2390420A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-06-13 | 1986-12-13 | 1987-06-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-06-13 | 1990-12-13 | 1991-06-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-06-13 | 1994-12-13 | 1995-06-14 | $7700.00 | Window Closed / Lapsed |