US4514386A
Expired / Lapsed
US
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Cream Preparation
Assignee: Sumitomo Chemical Co Ltd
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Filing: 1983-12-06
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Granted: 1985-04-30
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Expires: 2003-12-06
Abstract
Abstract An antiinflammatory cream preparation which comprises an antiinflammatory substance hardly soluble in water in a base composition at a concentration of 0.05 to 1.5% by weight based on the preparation, the base composition comprising a medium chain fatty acid triglyceride of which the fatty acid has 6 to 12 carbon atoms, carboxyvinyl polymer and purified water in a weight proportion of 1-25:0.3-3:75-99, and with an adjusted pH of 4 to 10. The cream preparation is excellent in the availability of the antiinflammatory substance contained therein and advantageously is low in stimulation and high in safety.
Inventors
- 👤 Yoshiya Yamahira
- 👤 Katsuhiko Shima
- 👤 Chikako Matsusaka
- 👤 Tetsuo Noguchi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:54
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/32; A61K47/06; A61K47/08; A61K47/14; A61K9/00; A61K9/0012; A61K9/0014; A61P; A61P29/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
82 words
A cream preparation which consist essentially of a pharmacologically active antiinflammatory substance which is hardly soluble in water in a base composition comprising 1 to 25 parts by weight of a medium chain fatty acid triglyceride of which the fatty acid has 6 to 12 carbon atoms, 0.3 to 3 parts by weight of a carboxypolymethylene and 75 to 99 parts by weight of purified water with an adjusted pH of 4 to 10, based on the weight of the base composition.
Claim 2
Dependent Claim
82 words
A cream preparation which consist essentially of a pharmacologically active antiinflammatory substance which is hardly soluble in water in a base composition comprising 1 to 25 parts by weight of a medium chain fatty acid triglyceride of which the fatty acid has 6 to 12 carbon atoms, 0.3 to 3 parts by weight of a carboxypolymethylene and 75 to 99 parts by weight of purified water with an adjusted pH of 4 to 10, based on the weight of the base composition.
Claim 3
Dependent Claim
13 words
The cream preparation according to claim 1, wherein the antiinflammatory substance is indomethacin.
Claim 4
Dependent Claim
13 words
The cream preparation according to claim 1, wherein the antiinflammatory substance is fluorometholone.
Claim 5
Dependent Claim
26 words
The cream preparation according to claim 1, wherein the active substance is included at a concentration of 0.05 to 1.5% by weight based on the preparation.
Claim 6
Dependent Claim
31 words
The cream preparation according to claim 1 wherein the medium chain fatty acid triglyceride is selected from the group consisting of caproic acid triglyceride, capric acid triglyceride, and caprylic-capric acid triglyceride.
Claim 7
Dependent Claim
22 words
The cream preparation according to claim 1 wherein the carboxypolymethylene is a hydrophilic polymer comprising acrylic acid as the major component thereof.
Claim 8
Dependent Claim
42 words
The cream preparation according to claim 1 wherein a dispersing aid or absorbing aid is incorporated into the base composition, said dispersing or absorbing aid being selected from the group consisting of glycerol, propylene glycol, sugar fatty acid esters and diisopropyl adipate.
Claim 9
Dependent Claim
29 words
The cream preparation according to claim 1 wherein the active antiinflammatory substance is selected from the group consisting of fluorometholone, prednisolone, dexamethasone, triamcinolone, diflorazone diacetate, indomethacin, ibuprofen and flurubiprofen.
Claim 10
Dependent Claim
32 words
The cream preparation according to claim 1 wherein the active antiinflammatory substance is present in an amount of about 0.05 to 1.15% by weight based on the weight of the cream preparation.
Claim 11
Dependent Claim
19 words
The cream preparation according to claim 1 wherein the pH is adjusted by the addition of a water-soluble amine.
References Cited (Backward Citations)
US4123433A
Cited
US4139625A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-04-29 | 1988-10-29 | 1989-04-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-04-29 | 1992-10-29 | 1993-04-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-04-29 | 1996-10-29 | 1997-04-30 | $7700.00 | Window Closed / Lapsed |