US4139625A
Expired / Lapsed
US
⏱️ 0.0 years remaining
5-(Substituted triphenylmethyl)picolinamides and their use as anti-acne agents
Assignee: Merck Sharp & Dohme LLC
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Filing: 1977-08-12
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Granted: 1979-02-13
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Expires: 1997-08-12
Abstract
Abstract Disclosed herein are novel 5-tritylpicolinic acids, amides, esters and pharmaceutically acceptable salts thereof. Also disclosed are methods for the use of said novel compounds as anti-acne agents.
Inventors
- 👤 Margaret H. Sherlock
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:20
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/06; C07D213/16; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/10; C07D211/12; C07D213/60; C07D213/61; C07D213/62; C07D213/63; C07D213/64; C07D213/78; C07D213/79; C07D213/81; C07D213/84; C07D213/89; C07D295/00; C07D295/02; C07D295/027
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
100 words
A compound of the formula: ##STR5## and the pharmaceutically acceptable salts thereof, wherein R is hydrogen or alkyl; each R 1 is a member selected from the group consisting of hydrogen, halogen, hydroxy, alkyl, cycloalkyl, alkoxy, cycloalkoxy, trifluoromethyl and phenyl; Q is a member selected from the group consisting of NR 2 R 3 , --NR 2 -alkylene-OH, pyrrolidino or pyrrolidino alkoxy, R 2 and R 3 which may be the same or different are members selected from the group consisting of hydrogen and alkyl wherein each alkyl, cycloalkyl, alkoxy, cycloalkoxy or alkylene group has up to 12 carbon atoms.
Claim 2
Dependent Claim
100 words
A compound of the formula: ##STR5## and the pharmaceutically acceptable salts thereof, wherein R is hydrogen or alkyl; each R 1 is a member selected from the group consisting of hydrogen, halogen, hydroxy, alkyl, cycloalkyl, alkoxy, cycloalkoxy, trifluoromethyl and phenyl; Q is a member selected from the group consisting of NR 2 R 3 , --NR 2 -alkylene-OH, pyrrolidino or pyrrolidino alkoxy, R 2 and R 3 which may be the same or different are members selected from the group consisting of hydrogen and alkyl wherein each alkyl, cycloalkyl, alkoxy, cycloalkoxy or alkylene group has up to 12 carbon atoms.
Claim 3
Dependent Claim
13 words
A compound of claim 1 wherein R and each R 1 are hydrogen.
Claim 4
Dependent Claim
20 words
A compond of claim 2 wherein Q is NR 2 R 3 and R 2 and R 3 are alkyl.
Claim 5
Dependent Claim
15 words
The compound of claim 2 wherein Q is NH 2 , said compound being 5-(triphenylmethyl)-picolinamide.
Claim 6
Dependent Claim
11 words
A compound of claim 2 wherein Q is --NR 2 -alkylene-OH.
Claim 7
Dependent Claim
17 words
The compound of claim 3 wherein R 2 and R 3 are ethyl, said compound being N,N-diethyl-5-(triphenylmethyl)-picolinamide.
Claim 8
Dependent Claim
119 words
A method of eliciting an anti-acne effect which comprises topically administering a therapeutically effective quantity of a compound of claim 1 of the formula: ##STR6## and the pharmaceutically acceptable salts thereof, wherein R is hydrogen or alkyl; each R 1 is a member selected from the group consisting of hydrogen, halogen, hydroxy, alkyl, cycloalkyl, alkoxy, cycloalkoxy, trifluoromethyl and phenyl; Q is a member selected from the group consisting of NR 2 R 3 , --NR 2 -alkylene-OH, pyrrolidino or pyrrolidino alkoxy, R 2 and R 3 which may be the same or different are members selected from the group consisting of hydrogen and alkyl wherein each alkyl, cycloalkyl, alkoxy, cycloalkoxy or alkylene group has up to 12 carbon atoms.
Claim 9
Dependent Claim
17 words
A method of treating as defined in claim 7 wherein R and each R 1 are hydrogen.
Claim 10
Dependent Claim
24 words
A method of treating as defined in claim 7 wherein Q is NR 2 R 3 ; R 2 and R 3 being alkyl.
Claim 11
Dependent Claim
27 words
A method of treating as defined in claim 7 wherein R and each R 1 are hydrogen, Q is --NR 2 -alkylene-OH and R 2 is hydrogen.
Claim 12
Dependent Claim
24 words
A method of treating as defined in claim 7 wherein Q is NR 2 R 3 ; R 2 and R 3 being hydrogen.
Claim 13
Dependent Claim
17 words
A method of treating as defined in claim 9 wherein R and each R 1 are hydrogen.
Claim 14
Dependent Claim
23 words
A method of treating as defined in claim 12 wherein R 2 and R 3 are ethyl, said treatment being effected with N,N-diethyl-5-(triphenylmethyl)-picolinamide.
Claim 15
Dependent Claim
19 words
The method of claim 11 wherein R and each R 1 are hydrogen, said treatment being effected with 5-(triphenylmethyl)-picolinamide.
References Cited (Backward Citations)
US3397273A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-12 | 1982-08-14 | 1983-02-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-12 | 1986-08-14 | 1987-02-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-12 | 1990-08-14 | 1991-02-13 | $7700.00 | Window Closed / Lapsed |