Patent US4780313A successfully refreshed from Google Patents.
US4780313A
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Method of stimulating the immune system with a mixture of substances having IL-2 activity and muramyldipeptide
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1986-12-18
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Granted: 1988-10-25
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Expires: 2006-12-18
Abstract
Abstract The combined use of an IL-2-active substance with a muramyldipeptide exhibiting a remarkably potent immunostimulant activity than the single use of the active ingredient is disclosed.
Inventors
- 👤 Ootsu Koichiro
- 👤 Goto Giichi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 07:30
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/19; A61K38/20; A61K38/2013; A61P; A61P35/00; A61P37/00; A61P37/02; A61P37/04; A61P43/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/14; Y10S930/141
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
44 words
A method for immunostimulating a warm-blooded animal, which comprises administering an effective amount of a substance having interleukin-2 activity in combination with an effective amount of a muramyldipeptide to said animal, wherein said interleukin-2 activity is activity to allow indefinite propagation of T cells.
Claim 2
Independent Claim
44 words
A method for immunostimulating a warm-blooded animal, which comprises administering an effective amount of a substance having interleukin-2 activity in combination with an effective amount of a muramyldipeptide to said animal, wherein said interleukin-2 activity is activity to allow indefinite propagation of T cells.
Claim 3
Dependent Claim
22 words
A method as claimed in claim 1, wherein the active substances are administered to a warm-blooded animal containing at least one tumor.
Claim 4
Dependent Claim
25 words
A method as claimed in claim 1, wherein the substance having interleukin-2 activity and the muramyldipeptide are administered in a form of a single preparation.
Claim 5
Dependent Claim
19 words
A method as claimed in claim 1, wherein the substance having interleukin-2 activity and the muramyldipeptide are separately administered.
Claim 6
Dependent Claim
19 words
A method as claimed in claim 1, wherein the substance having interleukin-2 activity is a recombinant non-glycosylated human interleukin-2.
Claim 7
Dependent Claim
23 words
A method as claimed in claim 5, wherein the recombinant non-glycosylated human interleukin-2 dose not have a methionine residue at the amino teminus.
Claim 8
Dependent Claim
99 words
A method as claimed in claim 1, wherein the muramyldipeptide is a compound of the formula: ##STR3## wherein R 1 is hydroxyl group or a C 2-50 carboxylic acid residue of the formula: ##STR4## wherein R 6 , R 7 and R 8 each dependently is a C 1-4 alkyl and n is an integer of 1 to 10, R 2 and R 3 is hydrogen or a hydroxyl-substituted or unsubstituted a C 1-6 alkyl group, R 4 is a hydroxyl group or a C 1-6 alkoxy group, and R 5 is a hydroxyl group or an amino group.
Claim 9
Dependent Claim
12 words
A method as claimed in claim 7, wherein the muramyldipeptide is N-acetylmuramyl-L-alanyl-D-isoglutamine.
Claim 10
Dependent Claim
12 words
A method as claimed in claim 7, wherein the muramyldipeptide is N-acetylmuramylaminoisobutyryl-D-isoglutamine.
Claim 11
Dependent Claim
12 words
A method as claimed in claim 7, wherein the muramyldipeptide is 6-0-[3-(2,3-dimethoxy-5-methyl-1,4-benzoquinon-6-yl)propionyl]-N-acetyl-muramyl-L-valyl-D-isoglutamine.
Claim 12
Dependent Claim
14 words
A method as claimed in claim 7, wherein the muramyldipeptide is 6-0-[10-(2,3-dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoyl)-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-10-25 | 1992-04-25 | 1992-10-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-10-25 | 1996-04-25 | 1996-10-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-10-25 | 2000-04-25 | 2000-10-25 | $7700.00 | Window Closed / Lapsed |