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US4401659A Expired / Lapsed US ⏱️ 0.0 years remaining

Muramyl-peptides fixed to peptide-polymers and pharmaceutical compositions containing them

Assignee: Bpifrance Financement SA
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Filing: 1980-01-14
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Granted: 1983-08-30
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Expires: 2000-01-14
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Abstract

Abstract A polymer of peptidic type formed by a chain formed from aminoacyl residues preferably derived of at least one of the amino-acid residues selected from the class consisting of α,γ-diaminobutyric acid, ornithine, lysine, homo-lysine, of which the lateral amino functions portionally carry peptide branches of which the aminoacyl residues are preferably derived of those selected from the class consisting of alanine, glycine, α-aminobutyric acid, valine, leucine and proline, the above-said peptide polymer having an average molecular weight comprised between about 50,000 and 250,000, and to which are bound covalently, muramyl-peptide units of which the two first aminoacid residues bound to the muramyl group are stereoisomers of the D series, the second aminoacid residue having the structure of the glutamic acid. This product is useful as anti-infectious agent.

Inventors

  • 👤 Pierre LeFrancier
  • 👤 Monique Parant
  • 👤 Francoise Audibert
  • 👤 Louis Chedid
  • 👤 Jean Choay
  • 👤 Michael Sela
  • 👤 Edgar Lederer

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-01 06:01
CPC Classifications
C; C07; C07K; C07K9/00; C07K9/001; C07K9/005; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/19; Y10S930/29

Claims Analysis

Total Claims: 31
Claim 1
Independent Claim 362 words
A pharmacologically active oligomeric peptide derivative which comprises (1) a polylysyl chain P which optionally includes branched chains formed of alanyl residues attached to the chain through the amino groups of lysyl groups in the chain not linked in the forming of said chain and (2) covalently linked to amino groups not linked into said chain P, muramyl peptide groups which comprise a glucopyranoside ring and linked thereto a peptide chain which chain comprises aminoacyl residues, the first of said aminoacyl residues being of an amino acid of the D-series and the second amino acyl residue being of D-glutamic acid, said oligomeric peptide derivative having the formula: ##STR6## in which the substituents R, R 1 , R 2 , R 4 , R 6 , X, Y, Z, x and n are defined as follows: R is either a hydrogen atom or alkyl group having from 1 to 4 carbon atoms, R 1 is hydrogen or alkyl having at most 4 carbon atoms or a simple or substituted aryl or alkyl-aryl having at most 10 carbon atoms, R 2 is hydrogen or alkyl, aryl or alkyl-aryl optionally substituted and having at most 22 carbon atoms, R 4 is hydrogen or acyl having at most 4 carbons, R 6 is hydrogen, a saturated or unsaturated acyl optionally branched having from 1 to about 90 carbon atoms and optionally having groups selected from the class consisting of hydroxyl, carboxyl, amino, cyclopropyl and methoxyl, X is an aminoacyl residue of the (D) series, selected from the class consisting of alanyl, arginyl, asparagyl, aspartyl, cystenyl, glutaminyl, glutamyl, histidyl, hydroxyprolyl, isoleucyl, leucyl, lysyl, methionyl, ornithyl, phenylalanyl, prolyl, seryl, threonyl, tryptophanyl, tyrosyl and valyl, Y is either --OH, or alkoxy having from 1 to 10 carbon atoms or --NH 2 group, of which one or the two hydrogens is optionally substituted by an alkyl having from 1 to 10 carbon atoms, Z is from 1 to 3 L- or D- identical or different aminoacyl residues, x is zero or an integer of 1 through 3, and n is a an integer other than zero, which integer is not more than the number of amino groups of chain P.
Claim 2
Dependent Claim 362 words
A pharmacologically active oligomeric peptide derivative which comprises (1) a polylysyl chain P which optionally includes branched chains formed of alanyl residues attached to the chain through the amino groups of lysyl groups in the chain not linked in the forming of said chain and (2) covalently linked to amino groups not linked into said chain P, muramyl peptide groups which comprise a glucopyranoside ring and linked thereto a peptide chain which chain comprises aminoacyl residues, the first of said aminoacyl residues being of an amino acid of the D-series and the second amino acyl residue being of D-glutamic acid, said oligomeric peptide derivative having the formula: ##STR6## in which the substituents R, R 1 , R 2 , R 4 , R 6 , X, Y, Z, x and n are defined as follows: R is either a hydrogen atom or alkyl group having from 1 to 4 carbon atoms, R 1 is hydrogen or alkyl having at most 4 carbon atoms or a simple or substituted aryl or alkyl-aryl having at most 10 carbon atoms, R 2 is hydrogen or alkyl, aryl or alkyl-aryl optionally substituted and having at most 22 carbon atoms, R 4 is hydrogen or acyl having at most 4 carbons, R 6 is hydrogen, a saturated or unsaturated acyl optionally branched having from 1 to about 90 carbon atoms and optionally having groups selected from the class consisting of hydroxyl, carboxyl, amino, cyclopropyl and methoxyl, X is an aminoacyl residue of the (D) series, selected from the class consisting of alanyl, arginyl, asparagyl, aspartyl, cystenyl, glutaminyl, glutamyl, histidyl, hydroxyprolyl, isoleucyl, leucyl, lysyl, methionyl, ornithyl, phenylalanyl, prolyl, seryl, threonyl, tryptophanyl, tyrosyl and valyl, Y is either --OH, or alkoxy having from 1 to 10 carbon atoms or --NH 2 group, of which one or the two hydrogens is optionally substituted by an alkyl having from 1 to 10 carbon atoms, Z is from 1 to 3 L- or D- identical or different aminoacyl residues, x is zero or an integer of 1 through 3, and n is a an integer other than zero, which integer is not more than the number of amino groups of chain P.
Claim 3
Dependent Claim 30 words
The oligomeric peptide derivative of claim 1 in which the chain P has branched peptide groups constituted of alanyl residues linked through the amino groups of the amino acyl residues.
Claim 4
Dependent Claim 34 words
The oligomeric peptide derivative of claim 2 in which the aminoacyl residues of the peptide groups are selected from amino acids of the group consisting of alanyl, alpha-aminobutyric acid, valyl, leucyl, isoleucyl or prolyl.
Claim 5
Dependent Claim 15 words
The oligomeric peptide derivative of claim 2 in which P consists of a polylysine chain.
Claim 6
Dependent Claim 15 words
The oligomeric peptide derivative of claim 1 in which the polymer is a L-lysyl polymer.
Claim 7
Dependent Claim 24 words
The oligomeric peptide derivative of claim 5 in which n is one integer less than the number of lysyl groups of the L-lysyl polymer.
Claim 8
Dependent Claim 24 words
The oligomeric peptide derivative of claim 1 in which the alnyl residues of the branched chains are of both the D- and L- series.
Claim 9
Dependent Claim 19 words
The oligomeric peptide derivative of claim 1 in which P includes L-polylysyl having linked thereto D- and/or L- alanyl.
Claim 10
Dependent Claim 43 words
The oligomeric peptide derivative of claim 8 in which the oligomeric peptide has an average molecular weight of 80,000 and the ratio of L-lysyl of P to the D- and L- alanyl of the branched chains linked thereto is between 1/10 to 1/30.
Claim 11
Dependent Claim 19 words
The oligomeric peptide derivative of claim 1 which has an average molecular weight from about 50,000 to about 250,000.
Claim 12
Dependent Claim 10 words
The oligomeric peptide derivative of claim 1 which is metabolizable.
Claim 13
Dependent Claim 26 words
The oligomeric peptide derivative of claim 1 wherein Y is --NH 2 , --OCH 3 , --OC 4 H 9 or OC 10 H 21 .
Claim 14
Dependent Claim 31 words
The oligomeric peptide derivative of claim 1 wherein x is 1 or 2 and Z is an aminoacyl residue selected from the group consisting of alanyl, glycyl, valyle, leucyle and isoleucyle.
Claim 15
Dependent Claim 13 words
The oligomeric peptide derivative of claim 1 wherein R is --CH 3 .
Claim 16
Dependent Claim 25 words
The oligomeric peptide derivative of claim 1 wherein R 1 , R 4 and R 6 are hydrogen and R 2 is --CH 3 .
Claim 17
Dependent Claim 14 words
The oligomeric peptide derivative of claim 9 wherein the muranyl peptide group are N-acetyl-muramyl-D-alanyl-D-isoglutaminyl.
Claim 18
Dependent Claim 20 words
The oligomeric peptide derivative of claim 1 wherein X is selected from the group consisting of D-prolyl, D-threonyl, and D-valyl.
Claim 19
Dependent Claim 14 words
The oligomeric peptide derivative of claim 1 wherein x is from 0 to 3.
Claim 20
Dependent Claim 13 words
The oligomeric peptide derivative of claim 1 wherein Y is --NH 2 .
Claim 21
Dependent Claim 30 words
The oligomeric peptide derivative of claim 1 wherein Y is selected from the group consisting of --OCH 3 , --OC 4 H 9 , or --OC 10 H 21 .
Claim 22
Dependent Claim 31 words
The oligomeric peptide derivative of claim 1 wherein R 2 is --CH 3 , R 1 , R 4 and R 6 are each hydrogen and R is --CH 3 .
Claim 23
Dependent Claim 15 words
The oligomeric peptide derivative of claim 1 wherein R is --C 2 H 5 .
Claim 24
Dependent Claim 22 words
The oligomeric peptide derivative of claim 1 wherein at least one of R 1 , R 4 and R 6 is hydrogen.
Claim 25
Dependent Claim 12 words
The oligomeric peptide derivative of claim 1 wherein R 4 is acetyl.
Claim 26
Dependent Claim 26 words
The oligomeric peptide derivative of claim 1 wherein R 6 is selected from the group consisting of acetyl of 1 to 4 carbons, mycolyl and corynomycolyl.
Claim 27
Dependent Claim 36 words
The oligomeric peptide derivative of claim 1 wherein R 1 , R 4 , and R 6 are hydrogen; R and R 2 are --CH 3 , X is D-alanyl and Y is --NH 2 .
Claim 28
Dependent Claim 10 words
The oligomeric peptide of claim 1 wherein X is D-alanyl.
Claim 29
Dependent Claim 62 words
A pharmaceutical composition for enhancing the resistance of a host against pathogens which comprises an effective amount of a biologically active oligomeric peptide derivative of any one of claims 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26 or 27 and a pharmaceutically acceptable carrier.
Claim 30
Independent Claim 65 words
The method for enhancing the resistance of a host against pathogens which comprises administering to said host an effective amount of a biologically active oligomeric peptide derivative of any one of claims 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, or 27 in a biologically acceptable carrier.
Claim 31
Dependent Claim 10 words
The oligomeric peptide derivative of claim 10 which is multi-poly-L-lysine.

References Cited (Backward Citations)

DE1155134B Cited
NL7413855A Cited
US4094971A Cited
DE2655500A1 Cited
US4082735A Cited
US4082736A Cited
FR2358159A1 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1986-08-29 1987-02-28 1987-08-30 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1990-08-29 1991-02-28 1991-08-30 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1994-08-29 1995-02-28 1995-08-30 $7700.00 Window Closed / Lapsed

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