Muramyl-peptides fixed to peptide-polymers and pharmaceutical compositions containing them

Claim 1

A pharmacologically active oligomeric peptide derivative which comprises (1) a polylysyl chain P which optionally includes branched chains formed of alanyl residues attached to the chain through the amino groups of lysyl groups in the chain not linked in the forming of said chain and (2) covalently linked to amino groups not linked into said chain P, muramyl peptide groups which comprise a glucopyranoside ring and linked thereto a peptide chain which chain comprises aminoacyl residues, the first of said aminoacyl residues being of an amino acid of the D-series and the second amino acyl residue being of D-glutamic acid, said oligomeric peptide derivative having the formula: ##STR6## in which the substituents R, R 1 , R 2 , R 4 , R 6 , X, Y, Z, x and n are defined as follows: R is either a hydrogen atom or alkyl group having from 1 to 4 carbon atoms, R 1 is hydrogen or alkyl having at most 4 carbon atoms or a simple or substituted aryl or alkyl-aryl having at most 10 carbon atoms, R 2 is hydrogen or alkyl, aryl or alkyl-aryl optionally substituted and having at most 22 carbon atoms, R 4 is hydrogen or acyl having at most 4 carbons, R 6 is hydrogen, a saturated or unsaturated acyl optionally branched having from 1 to about 90 carbon atoms and optionally having groups selected from the class consisting of hydroxyl, carboxyl, amino, cyclopropyl and methoxyl, X is an aminoacyl residue of the (D) series, selected from the class consisting of alanyl, arginyl, asparagyl, aspartyl, cystenyl, glutaminyl, glutamyl, histidyl, hydroxyprolyl, isoleucyl, leucyl, lysyl, methionyl, ornithyl, phenylalanyl, prolyl, seryl, threonyl, tryptophanyl, tyrosyl and valyl, Y is either --OH, or alkoxy having from 1 to 10 carbon atoms or --NH 2 group, of which one or the two hydrogens is optionally substituted by an alkyl having from 1 to 10 carbon atoms, Z is from 1 to 3 L- or D- identical or different aminoacyl residues, x is zero or an integer of 1 through 3, and n is a an integer other than zero, which integer is not more than the number of amino groups of chain P.

Claim 30

The method for enhancing the resistance of a host against pathogens which comprises administering to said host an effective amount of a biologically active oligomeric peptide derivative of any one of claims 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, or 27 in a biologically acceptable carrier.