US4772460A
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US
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Method of reducing the swelling or pain associated with antibiotics compositions
Assignee: Zoetis Broomhill IP Ltd
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Filing: 1986-10-01
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Granted: 1988-09-20
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Expires: 2006-10-01
Abstract
Abstract Oxytetracycline aqueous solutions, particularly for parenteral administration containing N-Methylpyrollidone as a solvent are disclosed.
Inventors
- 👤 Saif U. Malook
- 👤 Peter F. G. Boon
- 👤 James P. Morgan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 01:44
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K31/00; A61K31/65; A61K33/00; A61K33/06; A61K33/08; A61K33/14; A61K47/00; A61K47/02; A61K47/06; A61K47/22
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
112 words
A method of reducing the swelling or pain associated with the administration of a tetracycline-type compound, which comprises administering by injection to an animal in need thereof a tetracycline-type composition comprising an aqueous solution of: from 10 to 45% by weight of a tetracycline-type compound; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of tetracycline-type compound provided and; from 25 to 50% by weight of N-methylpyrollidone, the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the tetracycline-type compound.
Claim 2
Independent Claim
112 words
A method of reducing the swelling or pain associated with the administration of a tetracycline-type compound, which comprises administering by injection to an animal in need thereof a tetracycline-type composition comprising an aqueous solution of: from 10 to 45% by weight of a tetracycline-type compound; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of tetracycline-type compound provided and; from 25 to 50% by weight of N-methylpyrollidone, the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the tetracycline-type compound.
Claim 3
Dependent Claim
32 words
The method as claimed in claim 1 wherein the composition includes polyvinylpyrollidone having an average molecular weight of between 1,000 and 30,000 in a concentration of from 1 to 10% by weight.
Claim 4
Dependent Claim
20 words
The method as claimed in claim 2 wherein the average molecular weight of the polyvinylpyrollidone is between 2,000 and 20,000.
Claim 5
Dependent Claim
20 words
The method as claimed in claim 3 wherein the average molecular weight of the polyvinylpyrollidone is between 9,000 and 11,000.
Claim 6
Dependent Claim
20 words
The method as claimed in claim 1 including an anti-oxidant in a concentration of betweenn 0.1% and 2% by weight.
Claim 7
Dependent Claim
28 words
The method as claimed in claim 5 wherein the anti-oxidant is sodium formaldehyde sulphoxylate which is present in a concentration of between 0.4% to 0.6 % by weight.
Claim 8
Dependent Claim
19 words
The method as claimed in claim 1 wherein the tetracycline-type compound is oxytetracycline or a pharmacologically acceptable salt thereof.
Claim 9
Dependent Claim
15 words
The method as claimed in claim 7 wherein the tetracycline-type compound is oxytetracycline dihydrate salt.
Claim 10
Dependent Claim
14 words
The method as claimed in claim 8 wherein the magnesium compound is magnesium oxide.
Claim 11
Dependent Claim
23 words
The method as claimed in claim 8 wherein the oxytetracycline dihydrate is present in an amount of between 20 and 46% by weight.
Claim 12
Dependent Claim
14 words
The method as claimed in claim 7 wherein the tetracycline-type compound is oxytetracycline hydrochloride.
Claim 13
Dependent Claim
14 words
The method as claimed in claim 11 wherein the magnesium compound is magnesium chloride.
Claim 14
Dependent Claim
23 words
The method as claimed in claim 11 wherein the oxytetracycline hydrochloride is present in an amount of between 10 and 20% by weight.
Claim 15
Dependent Claim
22 words
The method as claimed in claim 1 wherein the N-methylpyrollidone is present in an amount of between 35% to 45% by weight.
Claim 16
Independent Claim
132 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 10 to 40% by weight of oxytetracycline or a pharmacologically acceptable salt thereof; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of oxytetracycline provided and; from 25 to 50% by weight of N-methylpyrollidone; and from 1 to 10% by weight of polyvinylpyrrolidone having an average molecular weight of between 2,000 and 20,000; the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
Claim 17
Independent Claim
132 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 10 to 40% by weight of oxytetracycline or a pharmacologically acceptable salt thereof; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of oxytetracycline provided and; from 25 to 50% by weight of N-methylpyrollidone; and from 1 to 10% by weight of polyvinylpyrrolidone having an average molecular weight of between 2,000 and 20,000; the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
Claim 18
Independent Claim
140 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 10 to 40% by weight of oxytetracycline or a pharmacologically acceptable salt thereof; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of oxytetracycline provided; from 25 to 50% by weight of N-methylpyrollidone; from 1 to 10% by weight of polyvinylpyrrolidone having an average molecular weight of between 2,000 and 20,000; and from 0.1% to 2% by weight of an anti-oxidant, the composition having a pH of from 7.5 to 9.5, said N-methyl pyrrolidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
Claim 19
Independent Claim
140 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 10 to 40% by weight of oxytetracycline or a pharmacologically acceptable salt thereof; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of oxytetracycline provided; from 25 to 50% by weight of N-methylpyrollidone; from 1 to 10% by weight of polyvinylpyrrolidone having an average molecular weight of between 2,000 and 20,000; and from 0.1% to 2% by weight of an anti-oxidant, the composition having a pH of from 7.5 to 9.5, said N-methyl pyrrolidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
Claim 20
Independent Claim
118 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 20 to 40% by weight of oxytetracycline dihydrate salt; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of oxytetracycline provided; from 35% to 40% by weight of N-methylpyrrolidone; and from 0.1% to 2% by weight of an anti-oxdant; the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
Claim 21
Independent Claim
118 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 20 to 40% by weight of oxytetracycline dihydrate salt; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 5% to 15% by weight of the amount of oxytetracycline provided; from 35% to 40% by weight of N-methylpyrrolidone; and from 0.1% to 2% by weight of an anti-oxdant; the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
Claim 22
Independent Claim
136 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 20 to 25% by weight of oxytetracycline dihydrate salt; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 7% to 10% by weight of the amount of oxytetracycline provided; from 35% to 40% by weight of N-methylpyrollidone; from 1 to 10% by weight of polyvinylpyrrolidone having an average molecular weight of between 9,000 to 11,000; and from 0.4 to 0.6% by weight of an anti-oxidant; the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
Claim 23
Independent Claim
136 words
A method of reducing the swelling or pain associated with the administration of an oxytetracycline which comprises administering by injection to an animal in need thereof an oxytetracycline composition comprising an aqueous solution of: from 20 to 25% by weight of oxytetracycline dihydrate salt; a magnesium compound soluble in the solution, said compound being provided in an amount which is from 7% to 10% by weight of the amount of oxytetracycline provided; from 35% to 40% by weight of N-methylpyrollidone; from 1 to 10% by weight of polyvinylpyrrolidone having an average molecular weight of between 9,000 to 11,000; and from 0.4 to 0.6% by weight of an anti-oxidant; the composition having a pH of from 7.5 to 9.5, said N-methyl pyrollidone being administered in an amount effective to reduce pain or swelling attributable to the oxytetracycline.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-09-20 | 1992-03-21 | 1992-09-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-09-20 | 1996-03-21 | 1996-09-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-09-20 | 2000-03-21 | 2000-09-20 | $7700.00 | Window Closed / Lapsed |