US4081528A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Tetracycline compositions
Assignee: Pfizer Inc
•
Filing: 1976-12-07
•
Granted: 1978-03-28
•
Expires: 1996-12-07
Abstract
Abstract Aqueous solutions of tetracycline or salts thereof, a pharmaceutically acceptable soluble magnesium compound and 2-pyrrolidone as a co-solvent, said solution having a pH of 7.5 to 9.5 and being useful as an injectable composition combining low viscosity, high potency, good clarity and good stability.
Inventors
- 👤 William W. Armstrong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 04:00
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/785; A61K31/787; A61K31/79; A61K9/00; A61K9/0012; A61K9/0014; A61K31/65; A61K47/00; A61K47/02; A61K47/06; A61K47/22; A61K9/0019; A61P; A61P31/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
80 words
A tetracycline composition comprising an aqueous solution of from about 1 to 15% by weight of an antibiotic compound selected from the group consisting of tetracycline and the pharmaceutically acceptable acid addition salts thereof, from about 0.8 to 1.3 molar proportions based on said antibiotic of a pharmaceutically acceptable magnesium compound solube in said solution, and from about 10 to 70% by weight of 2-pyrrolidone, said composition having a pH value in the range of from about 7.5 to 9.5.
Claim 2
Dependent Claim
80 words
A tetracycline composition comprising an aqueous solution of from about 1 to 15% by weight of an antibiotic compound selected from the group consisting of tetracycline and the pharmaceutically acceptable acid addition salts thereof, from about 0.8 to 1.3 molar proportions based on said antibiotic of a pharmaceutically acceptable magnesium compound solube in said solution, and from about 10 to 70% by weight of 2-pyrrolidone, said composition having a pH value in the range of from about 7.5 to 9.5.
Claim 3
Dependent Claim
13 words
A composition as claimed in claim 1 wherein said antibiotic compound is tetracycline.
Claim 4
Dependent Claim
19 words
A composition as claimed in claim 1 wherein said magnesium compound is introduced in the form of magnesium oxide.
Claim 5
Dependent Claim
35 words
A composition of claim 1 wherein polyvinylpyrrolidone having an average molecular weight of between about 5,000 and 100,000 is also present in a concentration of from about 1 to 7% by weight of the total.
Claim 6
Dependent Claim
24 words
A composition as claimed in claim 1 wherein said antibiotic compound is present at a level of from about 5 to 15% by weight.
Claim 7
Dependent Claim
24 words
A composition as claimed in claim 1 wherein said antibiotic compound is present at a level of from about 5 to 10% by weight.
Claim 8
Dependent Claim
17 words
A composition as claimed in claim 1 having a pH value of from about 8 to 9.
Claim 9
Dependent Claim
71 words
A tetracycline composition comprising an aqueous solution of from about 5 to 10% by weight of tetracycline, from about 0.8 to 1.3 molar proportions based on tetracycline of a pharmaceutically acceptable magnesium compound soluble in said solution, from about 60 to 70% by weight of 2-pyrrolidone and from about 1 to 7% by weight of polyvinylpyrrolidone, said composition having a pH value in the range of from about 8 to 9.
Claim 10
Dependent Claim
71 words
A tetracycline composition comprising an aqueous solution of from about 5 to 10% by weight of tetracycline, from about 0.8 to 1.3 molar proportions based on tetracycline of a pharmaceutically acceptable magnesium compound soluble in said solution, from about 60 to 70% by weight of 2-pyrrolidone and from about 1 to 7% by weight of polyvinylpyrrolidone, said composition having a pH value in the range of from about 8 to 9.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-27 | 1981-09-26 | 1982-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-27 | 1985-09-26 | 1986-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-27 | 1989-09-26 | 1990-03-28 | $7700.00 | Window Closed / Lapsed |