US3957972A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stable solutions of oxytetracycline suitable for parenteral and peroral administration and process of preparation
Assignee: DSM Delft BV
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Filing: 1972-06-28
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Granted: 1976-05-18
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Expires: 1992-06-28
Abstract
Abstract The present invention relates to a clear, stable, aqueous solution of oxytetracycline for medical applications consisting essentially of from 1% to 5% by weight of oxytetracycline and water containing polyvinyl pyrrolidone and a magnesium compound, said aqueous solution having a pH in the range of from 8.0 to 9.5 and a concentration of polyvinyl pyrrolidone of from 2.5% to 7.49% as well as to the process of preparing the same. The oxytetracycline solutions are utilized in parenteral and peroral administrations, are free from adverse side effects and are stable over long periods of storage.
Inventors
- 👤 Hubert Antonius Weber, deceased
- 👤 Adrianus Pieter Molenaar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 12:02
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/65; A61K31/74; A61K31/785; A61K31/787; A61K31/79
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
92 words
A clear, stable, aqueous solution of oxytetracycline for medical applications consisting essentially of from 1% to 5% by weight of oxytetracycline and water containing polyvinyl pyrrolidone having a molecular weight in the range of 3,000 to 60,000 and a magnesium compound capable of supplying magnesium ions, said aqueous solution having a pH in the range of from 8.0 to 9.5 and a concentration of polyvinyl pyrrolidone of from 2.5 to 7.49%, the amount of said magnesium compound being selected so that essentially all of the magnesium ions are complexed by the oxytetracycline.
Claim 2
Dependent Claim
92 words
A clear, stable, aqueous solution of oxytetracycline for medical applications consisting essentially of from 1% to 5% by weight of oxytetracycline and water containing polyvinyl pyrrolidone having a molecular weight in the range of 3,000 to 60,000 and a magnesium compound capable of supplying magnesium ions, said aqueous solution having a pH in the range of from 8.0 to 9.5 and a concentration of polyvinyl pyrrolidone of from 2.5 to 7.49%, the amount of said magnesium compound being selected so that essentially all of the magnesium ions are complexed by the oxytetracycline.
Claim 3
Dependent Claim
34 words
The aqueous solution of claim 1 wherein said polyvinyl pyrrolidone is present in a concentration of from 3% to 7.4% and amounts to from 1.5 to 3 times by weight the amount of oxytetracycline.
Claim 4
Dependent Claim
40 words
The aqueous solution of claim 1 wherein said magnesium compound is present in an amount of from 1 to 1.5 mols per mol of oxytetracycline and is selected from the group consisting of magnesium oxide, magnesium chloride and magnesium sulfate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-18 | 1979-11-17 | 1980-05-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-18 | 1983-11-17 | 1984-05-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-18 | 1987-11-17 | 1988-05-18 | $7700.00 | Window Closed / Lapsed |