US4762702A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical preparation containing ibuprofen and a process for its preparation
Assignee: Individual
•
Filing: 1985-11-04
•
Granted: 1988-08-09
•
Expires: 2005-11-04
Abstract
Abstract A pharmaceutical preparation containing ibuprofen is disclosed. In the preparation, the ibuprofen particles are enveloped by a coating of a hydro-colloid and fumaric acid. Preferably, the hydro-colloid comprises xanthan gum and/or maltodextrin. This preparation reduces the tendency of ibuprofen to irritate the esophagus and the gastrointestinal tract when taken orally. An effervescent mixture of the ibuprofen containing preparation can be prepared by incorporating citric acid and calcium carbonate into the mixture. A process for the manufacture of the ibuprofen containing preparation is also disclosed. In this process, ibuprofen particles are coated with the hydro-colloid and fumaric acid under vacuum conditions in a vacuum mixing machine and the resulting preparation is thereafter vacuum-dried.
Inventors
- 👤 Gerhard Gergely
- 👤 Thomas Gergely
- 👤 Irmgard Gergely
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 04:57
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617; A61K31/00; A61K31/185; A61K31/19; A61K9/0002; A61K9/0007; A61K9/1629; A61K9/1652; A61P; A61P29/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
35 words
An ibuprofen containing pharmaceutical preparation for making up an instant drink and comprising a therapeutically effective amount of ibuprofen particles, a hydro-colloid, and fumaric acid, wherein said hydro-colloid and fumaric acid coat said ibuprofen particles.
Claim 2
Dependent Claim
35 words
An ibuprofen containing pharmaceutical preparation for making up an instant drink and comprising a therapeutically effective amount of ibuprofen particles, a hydro-colloid, and fumaric acid, wherein said hydro-colloid and fumaric acid coat said ibuprofen particles.
Claim 3
Dependent Claim
11 words
The pharmaceutical preparation of claim 1 wherein said pseudo-colloid contains maltodextrin.
Claim 4
Dependent Claim
11 words
The pharmaceutical preparation of claim 1 further comprising an effervescent mixture.
Claim 5
Dependent Claim
16 words
The pharmaceutical preparation of claim 3 wherein said effervescent mixture comprises citric acid and calcium carbonate.
Claim 6
Dependent Claim
35 words
The pharmaceutical preparation of claim 1, comprising about 200 parts by weight of ibuprofen, 10 parts by weight of xanthan gum, 10 parts by weight of maltodextrin, and 20 parts by weight of fumaric acid.
Claim 7
Dependent Claim
23 words
The pharmaceutical preparation of claim 5, further comprising 50 parts by weight of citric acid and 50 parts by weight of calcium carbonate.
Claim 8
Dependent Claim
33 words
A process for the manufacture of an ibuprofen containing pharmaceutical preparation, comprising enveloping ibuprofen particles with a coating of a hydro-colloid and fumaric acid under vacuum conditions, and vacuum drying the resulting mixture.
Claim 9
Dependent Claim
33 words
A process for the manufacture of an ibuprofen containing pharmaceutical preparation, comprising enveloping ibuprofen particles with a coating of a hydro-colloid and fumaric acid under vacuum conditions, and vacuum drying the resulting mixture.
Claim 10
Dependent Claim
52 words
A process in accordance with claim 7, wherein said ibuprofen particles and a hydro-colloid are mixed with water under a pressure of about 0.1 bar, said mixture is partially dried to a pressure of about 0.2 bar, fumaric acid is added to this mixture, and the resulting mixture is dried to completion.
References Cited (Backward Citations)
GB970462A
Cited
US3772430A
Cited
US3882228A
Cited
US3887700A
Cited
US3676549A
Cited
US3764668A
Cited
US3773922A
Cited
US3875073A
Cited
JPS551244A
Cited
US4344934A
Cited
JPS5592341A
Cited
US4540602A
Cited
JPS5634618A
Cited
JPS5646838A
Cited
JPS5646837A
Cited
JPS5646839A
Cited
US4417993A
Cited
US4344929A
Cited
JPS58198417A
Cited
US4614648A
Cited
US4593020A
Cited
US4678661A
Cited
US4613497A
Cited
WO1986002834A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-08-09 | 1992-02-08 | 1992-08-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-08-09 | 1996-02-08 | 1996-08-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-08-09 | 2000-02-08 | 2000-08-09 | $7700.00 | Window Closed / Lapsed |