US4614648A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Process for manufacturing effervescent granules and tablets
Assignee: Individual
•
Filing: 1983-12-20
•
Granted: 1986-09-30
•
Expires: 2003-12-20
Abstract
Abstract The invention relates to a process for manufacturing effervescent tablets consisting in the steps of careful humidifying of the acid+base mixture, pre-drying and final drying and granulating. It has been found that these operations can be performed in a single apparatus, either integrally in fluid bed, or with vacuum-drying.
Inventors
- 👤 Jean Bru
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 04:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0002; A61K9/0007; B; B01; B01J; B01J2/00; B01J2/16
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
61 words
A process for the manufacture of effervescent tablets in which the powdered raw materials therefor are mixed and the mixture is carefully humidified by a solvent followed by granulation and drying, wherein the steps of mixing said raw materials, humidifying the mixture with the solvent and drying are conducted inside the same apparatus, wherein the drying step is performed in vacuo.
Claim 2
Dependent Claim
61 words
A process for the manufacture of effervescent tablets in which the powdered raw materials therefor are mixed and the mixture is carefully humidified by a solvent followed by granulation and drying, wherein the steps of mixing said raw materials, humidifying the mixture with the solvent and drying are conducted inside the same apparatus, wherein the drying step is performed in vacuo.
Claim 3
Dependent Claim
24 words
The process of claim 1, wherein the components of the mixture are: effervescent mixture: sodium bicarbonate citric acid and the solvent is demineralized water.
Claim 4
Dependent Claim
11 words
The process of claim 2, wherein the effervescent mixture contains glycocoll.
Claim 5
Dependent Claim
30 words
The process of claim 1, wherein the mixture comprises: paracetamol monosodium carbonate monopotassium carbonate sorbitol anhydrous citric acid ascorbic acid and the solvent is a solution of manoxol in water.
Claim 6
Dependent Claim
39 words
The process of claim 1, wherein said apparatus comprises in particular: mixing means means for introducing the solvent means for regulating the temperature means for creating a vacuum, and drying is obtained in this apparatus by creating a vacuum.
Claim 7
Dependent Claim
18 words
The process of claim 5, wherein the granules are then cooled by passing in a heat exchange hopper.
Claim 8
Dependent Claim
61 words
The process of claim 5, wherein the mixing means comprises a system of mechanical stirring with lump-breaking cutters, the means for introducing the solvent comprises a system of aspiration of the solvent by creation of a vacuum or a spraying system supplied by a pump, and the means for regulating the temperature comprises a double jacket where a heat-exchange fluid circulates.
Claim 9
Dependent Claim
25 words
The process of claim 7, wherein the raw materials in powder form are as follows: paracetamol vitamin C sodium bicarbonate citric acid potassium bicarbonate sorbitol.
Claim 10
Dependent Claim
23 words
A process as claimed in claim 5 wherein the raw materials in powdered form are as follows: calcium carbasalate lysine carbamate citric acid.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-29 | 1990-03-31 | 1990-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-29 | 1994-03-31 | 1994-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-29 | 1998-03-31 | 1998-09-30 | $7700.00 | Window Closed / Lapsed |