Process for manufacturing effervescent granules which may be transformed, when required, into effervescent tablets

Abstract

Abstract 1. Procedure for the manufacture of effervescent granules that can possibly be processed into effervescent tablets by heat treatment, at a temperature between 30 degrees C and 100 degrees C, of a powdered or granular mixture consisting of an acid or acid carbonate and/or a carbonate as effervescent components in a closed system under vacuum, according to which procedure the acid, possibly after a preliminary treatment at a high temperature, is mixed with a required quantity of acid carbonate and/or carbonate and such mixture is then exposed to a treatment under vacuum at a temperature from 30 degrees C up to 100 degrees C, but preferably from 40 degrees C to 80 degrees C, at which the mixture is mixed with a polar solvent such as water, methanol, ethanol or mixtures of such solvents, after which steps the aggregates thus obtained are crushed into particles of the required size and are possibly provided with desired additives and possibly reduced into tablets, such procedure being characterized by the fact that, for the passivation of the surface of at least one of the components of the reaction and so as to reduce the components to a state of strong inertia to the reaction, there is added to the mixture during the treatment under vacuum a metered quantity of polar solvent up to 7% of the mass considered as being the mass of the mixture which has to be treated, the difference in pressure caused by development of carbon dioxide through the addition of solvent during the reaction is determined up to a maximum of 1,000 m-bars, the volume and mass of the carbon dioxide liberated are ascertained from this difference in pressure, and the heat treatment is repeated, after rapid drying of the mixture, as many times as are necessary to obtain passivation of the surface as indicated by an evident slowing down of the reaction and by a reduced development of gas.

Inventors

• 👤 Gerhard Dr. Gergely

Bibliographic Details