US4760157A
Expired / Lapsed
US
⏱️ 0.0 years remaining
(2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
Assignee: Wyeth Holdings LLC
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Filing: 1986-01-31
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Granted: 1988-07-26
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Expires: 2006-01-31
Abstract
Abstract Novel organic-platinum compounds selected from those of the formulae: ##STR1## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR2## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR3## taken together is ascorbic acid and X is selected from the group consisting of halogen and hydroxy.
Inventors
- 👤 Ralph G. Child
- 👤 Panayota Bitha
- 👤 Joseph J. Hlavka
- 👤 Yang-I Lin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 18:48
CPC Classifications
C; C07; C07F; C07F17/00; C07F17/02; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
93 words
A compound selected from those of the formulae: ##STR10## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR11## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR12## taken together is ascorbic acid and X is selected from the group consisting of halogen and hydroxy.
Claim 2
Dependent Claim
93 words
A compound selected from those of the formulae: ##STR10## wherein L and L' are selected from the group consisting of halide, nitrate, sulfate and a monobasic carboxylate such as acetate or hydroxy acetate or L and L' taken together are a dibasic carboxylate selected from the group consisting of ##STR11## oxalic acid, methylmalonic acid, succinic acid and tartronic acid, or L and L' taken together are a tribasic carboxylate selected from the group consisting of ##STR12## taken together is ascorbic acid and X is selected from the group consisting of halogen and hydroxy.
Claim 3
Dependent Claim
7 words
The compound according to claim 1, [2,2-bis(aminomethyl)-1,3-propanediol-N,N']dichloroplatinum.
Claim 4
Dependent Claim
10 words
The compound according to claim 1, [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][propanedioato-(2-)-O 1 ,O.sup.3 ]platinum.
Claim 5
Dependent Claim
11 words
The compound according to claim 1, [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][[1,1'-cyclobutanedicarboxylato](2-)-O 1 ,O 1 ]platinum.
Claim 6
Dependent Claim
10 words
The compound according to claim 1, [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][pentanedioato(2-)O 1 ,O.sup.5 ]platinum.
Claim 7
Dependent Claim
38 words
A composition of matter in dosage unit form comprising from about 1 mg to about 1.2 g per square meter of mammalian body surface area of a compound of claim 1 in association with a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
34 words
The compound selected from the group consisting of [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][[2,2'-oxybis[acetato]](2-)-O.sup.1,O 1 ]platinum, [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][3,4-dihydroxy-3-cyclobutene-1,2-dionato(2-)-O 3 ,O 4 ]platinum, [2,2-bisaminomethyl)-1,3-propanediol-N,N'][[2,2'-sulfonylbis-[acetato]](2-)-O 1 ,O 1 ]platinum, 2,2-bis(aminomethyl)-1,3-propanediol-N,N']bis[hydroxyacetato(1-)-O']platinum, [2,2-bis-(aminomethyl)-1,3-propanediol-N,N'][1,1,2-ethanetricarboxylato(2-)-O 1 ,O 1 ]platinum, [2,2-bis(aminomethyl)-1,3-propanediol-N,N')tetrachloroplatinum, and [2,2-bis(aminomethyl)-1,3-propanediol-N,N'-][1,1'-cyclobutanedicarboxylato(2-)-O 1 ,O 1 ]dihydroxyplatinum.
Claim 9
Dependent Claim
34 words
The compound selected from the group consisting of [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][[2,2'-oxybis[acetato]](2-)-O.sup.1,O 1 ]platinum, [2,2-bis(aminomethyl)-1,3-propanediol-N,N'][3,4-dihydroxy-3-cyclobutene-1,2-dionato(2-)-O 3 ,O 4 ]platinum, [2,2-bisaminomethyl)-1,3-propanediol-N,N'][[2,2'-sulfonylbis-[acetato]](2-)-O 1 ,O 1 ]platinum, 2,2-bis(aminomethyl)-1,3-propanediol-N,N']bis[hydroxyacetato(1-)-O']platinum, [2,2-bis-(aminomethyl)-1,3-propanediol-N,N'][1,1,2-ethanetricarboxylato(2-)-O 1 ,O 1 ]platinum, [2,2-bis(aminomethyl)-1,3-propanediol-N,N')tetrachloroplatinum, and [2,2-bis(aminomethyl)-1,3-propanediol-N,N'-][1,1'-cyclobutanedicarboxylato(2-)-O 1 ,O 1 ]dihydroxyplatinum.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-26 | 1992-01-25 | 1992-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-26 | 1996-01-25 | 1996-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-26 | 2000-01-25 | 2000-07-26 | $7700.00 | Window Closed / Lapsed |