US4587331A
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Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes
Assignee: Wyeth Holdings LLC
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Filing: 1984-12-17
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Granted: 1986-05-06
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Expires: 2004-12-17
Abstract
Abstract Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes useful for inducing regression and/or palliation of cancer diseases in mammals.
Inventors
- 👤 Joseph J. Hlavka
- 👤 Ralph G. Child
- 👤 Panayota Bitha
- 👤 Yang I. Lin
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 19:58
CPC Classifications
C; C07; C07H; C07H23/00; A; A61; A61P; A61P35/00; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
176 words
A compound in linear or cyclic form selected from those of the formulae: ##STR5## wherein in cyclic form (1) R 1 is selected from the group consisting of hydrogen, alkyl (C 1 -C 3 ), hydroxymethyl and aminomethyl; and R 2 , R 3 and R 4 are each individually selected from the group consisting of hydroxy and amino with the proviso that at least one of R 2 , R 3 and R 4 must be hydroxy; and wherein in linear form (2) R 5 is selected from the group consisting of ##STR6## and n is an integer 2-4 and R 6 is selected from the group consisting of methyl, hydroxymethyl and aminomethyl; and wherein in both cyclic (1) and linear form (2), A is selected from the group consisting of ##STR7## wherein L and L' are the same or different and are each selected from the group consisting of halide, nitrate and sulfate and L and L' taken together is selected from the group consisting of oxalic, malonic, methylmalonic, succinic, tartronic and 1,1-cyclobutanedicarboxylic acids.
Claim 2
Dependent Claim
176 words
A compound in linear or cyclic form selected from those of the formulae: ##STR5## wherein in cyclic form (1) R 1 is selected from the group consisting of hydrogen, alkyl (C 1 -C 3 ), hydroxymethyl and aminomethyl; and R 2 , R 3 and R 4 are each individually selected from the group consisting of hydroxy and amino with the proviso that at least one of R 2 , R 3 and R 4 must be hydroxy; and wherein in linear form (2) R 5 is selected from the group consisting of ##STR6## and n is an integer 2-4 and R 6 is selected from the group consisting of methyl, hydroxymethyl and aminomethyl; and wherein in both cyclic (1) and linear form (2), A is selected from the group consisting of ##STR7## wherein L and L' are the same or different and are each selected from the group consisting of halide, nitrate and sulfate and L and L' taken together is selected from the group consisting of oxalic, malonic, methylmalonic, succinic, tartronic and 1,1-cyclobutanedicarboxylic acids.
Claim 3
Dependent Claim
9 words
The compound according to claim 1, 2-amino-2-deoxy-β-D-glucopyranose platinum chloride.
Claim 4
Dependent Claim
9 words
The compound according to claim 1, α-D-lyxopyranosylamine platinum chloride.
Claim 5
Dependent Claim
9 words
The compound according to claim 1, D-mannopyranosylamine platinum chloride.
Claim 6
Dependent Claim
9 words
The compound according to claim 1, 2,3-diamino-2,3-dideoxy-α-D-glucopyranose platinum chloride.
Claim 7
Dependent Claim
9 words
The compound according to claim 1, 1,2-diamino-1,2-dideoxy-D-glucitol platinum chloride.
Claim 8
Dependent Claim
9 words
The compound according to claim 1, D-ribopyranosylamine platinum chloride.
Claim 9
Dependent Claim
9 words
The compound according to claim 1, D-galactopyranosylamine platinum chloride.
Claim 10
Dependent Claim
10 words
The compound according to claim 1, 2-amino-2-deoxy-D-gluconic acid platinum chloride.
Claim 11
Dependent Claim
9 words
The compound according to claim 1, D-arabinopyranosylamine platinum chloride.
Claim 12
Dependent Claim
9 words
The compound according to claim 1, 1,2-diamino-1,2-dideoxy-D-mannitol platinum chloride.
Claim 13
Dependent Claim
9 words
The compound according to claim 1, 1,2-diamino-1,2-dideoxy-D-glucose dichlorodihydroxy platinum.
Claim 14
Dependent Claim
9 words
The compound according to claim 1, 6-amino-6-deoxy-α-D-glucopyranose platinum chloride.
Claim 15
Dependent Claim
9 words
The compound according to claim 1, 2,6-diamino-2,6-dideoxy-α-D-glucopyranose, platinum chloride.
Claim 16
Dependent Claim
9 words
The compound according to claim 1, 2-amino-2-deoxy-D-glucopyranosylamine platinum chloride.
Claim 17
Dependent Claim
9 words
The compound according to claim 1, D-xylopyranosylamine platinum chloride.
Claim 18
Dependent Claim
7 words
The compound according to claim 1, 1,2-diamino-1,2-dideoxy-D-glucitol[1,1-cyclobutanedicarboxylato(2-)]platinum.
Claim 19
Dependent Claim
10 words
The compound according to claim 1, 2-amino-2-deoxy-D-glucose hydrazone platinum chloride.
Claim 20
Dependent Claim
10 words
The compound according to claim 1, L-arabinose hydrazone platinum chloride.
Claim 21
Dependent Claim
10 words
The compound according to claim 1, D-galactose hydrazone platinum chloride.
Claim 22
Dependent Claim
10 words
The compound according to claim 1, 6-deoxy-L-galactose hydrazone platinum chloride.
Claim 23
Dependent Claim
10 words
The compound according to claim 1, D-arabinose hydrazone platinum chloride.
Claim 24
Dependent Claim
9 words
The compound according to claim 1, 1-deoxy-1-hydrazino-D-arabinitol platinum chloride.
Claim 25
Dependent Claim
7 words
The compound according to claim 1, 2,3-diamino-2,3-dideoxy-D-glucopyranose[1,1-cyclobutanedicarboxylato(2-)-0,0']platinum.
Claim 26
Dependent Claim
6 words
The compound 2-deoxy-D-streptamine platinum bromide chloride.
Claim 27
Dependent Claim
6 words
The compound 2-deoxy-D-streptamine platinum bromide chloride.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-05 | 1989-11-04 | 1990-05-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-05 | 1993-11-04 | 1994-05-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-05 | 1997-11-04 | 1998-05-06 | $7700.00 | Window Closed / Lapsed |