US4500465A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Solubilized platinum (II) complexes
Assignee: BASF Catalysts LLC
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Filing: 1982-06-28
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Granted: 1985-02-19
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Expires: 2002-06-28
Abstract
Abstract There are described platinum-polyhydroxylated amine compounds which exhibit anti-tumor activity in mammalian species. The products are highly soluble in aqueous solutions and they may be administered either orally or in parenteral form.
Inventors
- 👤 Alan R. Amundsen
- 👤 Eric W. Stern
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 14:53
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
39 words
A platinum-amine compound of the formula: cis[Pt(A) 2 (X) 2 ] wherein A represents a polyhydroxylated amine and A 2 represents a polyhydroxylated diamine, and A and A 2 are selected from among 2-methyl-2-amino-1,3-propanediol, tris(hydroxymethyl)methylamine, 2,3-dihydroxypropylamine, 2,2,2-tris(hydroxymethyl)ethylamine, 2-amino-2-ethyl-1,3-propanediol, 2,3,4,5,6-pentahydroxyhexylamine,
Claim 2
Dependent Claim
39 words
A platinum-amine compound of the formula: cis[Pt(A) 2 (X) 2 ] wherein A represents a polyhydroxylated amine and A 2 represents a polyhydroxylated diamine, and A and A 2 are selected from among 2-methyl-2-amino-1,3-propanediol, tris(hydroxymethyl)methylamine, 2,3-dihydroxypropylamine, 2,2,2-tris(hydroxymethyl)ethylamine, 2-amino-2-ethyl-1,3-propanediol, 2,3,4,5,6-pentahydroxyhexylamine,
Claim 3
Dependent Claim
42 words
3,3-tris(hydroxymethyl)propylamine, 1,2-diamino-4,5-dihydroxycyclohexane, 1,2-diamino-3,4,5-trihydroxycyclopentane, 2-(tris(hydroxymethyl)methyl)-1,3-diaminopropane 2,3-bis(hydroxymethyl)ethylenediamine; and the X radicals are anionic ligands selected from the group consisting of halo, carboxylato or, taken together, the X radicals represent dicarboxylato, sulfato, orthophosphato, or pyrophosphato, or a combination of aquo and sulfato, orthophosphato or pyrophosphato.
Claim 4
Dependent Claim
42 words
3,3-tris(hydroxymethyl)propylamine, 1,2-diamino-4,5-dihydroxycyclohexane, 1,2-diamino-3,4,5-trihydroxycyclopentane, 2-(tris(hydroxymethyl)methyl)-1,3-diaminopropane 2,3-bis(hydroxymethyl)ethylenediamine; and the X radicals are anionic ligands selected from the group consisting of halo, carboxylato or, taken together, the X radicals represent dicarboxylato, sulfato, orthophosphato, or pyrophosphato, or a combination of aquo and sulfato, orthophosphato or pyrophosphato.
Claim 5
Dependent Claim
14 words
The compound according to claim 1 wherein the X groups are each halide anions.
Claim 6
Dependent Claim
10 words
The compound according to claim 1 wherein A is 2-methyl-2-amino-1,3-propanediol.
Claim 7
Dependent Claim
10 words
The compound according to claim 1 wherein A is tris(hydroxymethyl)methylamine.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-19 | 1988-08-20 | 1989-02-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-19 | 1992-08-20 | 1993-02-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-19 | 1996-08-20 | 1997-02-19 | $7700.00 | Window Closed / Lapsed |