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US4250189A Expired / Lapsed US ⏱️ 0.0 years remaining

Compositions containing platinum

Assignee: Johnson Matthey PLC
•
Filing: 1979-04-18
•
Granted: 1981-02-10
•
Expires: 1999-04-18
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Abstract

Abstract This invention relates to platinum co-ordination compounds, to pharmaceutical compositions containing them. Examples of compositions falling within the scope of the present invention include: [Pt(II)(NR.sub. 1 R.sub.2)(NR.sub. 3 R.sub.4)-(CR.sub.5 R.sub.6)(X)(Y)] or (1) [Pt(II)(NR.sub. 1 R.sub.2)(NR.sub. 3 R.sub.4)-(CR.sub.5 R.sub.6)(CR.sub. 5 R 6 )(CR.sub. 7 R 8 )(X)(Y)] or (2) [Pt(IV)(NR.sub. 1 R.sub.2)(NR.sub. 3 R.sub.4)-(CR.sub.5 R 6 )(X)(Y)(Z).sub. 2 ] or (3) [Pt(IV)(NR.sub. 1 R.sub.2)(NR.sub. 3 R.sub.4)-(CR.sub.5 R.sub.6)(CR.sub. 7 R 8 )(X)(Y)(Z).sub. 2 ] (4) the R groups may be the same or different and are selected from H, straight-or branched-chain alkyl, aryl, alkaryl, aralkyl, alkenyl, cydoalkyl, cycloalkenyl, halogen, pseudohalogen (as hereinafter defined), hydroxy, alkoxy, aryloxy, formyl, nitro, amido, amino, sulphonic acids or salts thereof and carboxlic esters, acids and salts thereof, or, two R groups may together represent oxygen or sulphur, and X and Y are the same or different ligands and are selected from sulphate, phosphate, nitrate, carboxylate, substituted carboxylate and water and where R is not H or straight-chain alkyl, additionally halogen or pseudohalogen, and Z is halogen, or pseudohalogen or hydroxy.

Inventors

  • 👤 Paul D. Hydes
  • 👤 David M. Watkins

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-28 11:29
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; C07C; C07C53/00; C07C53/08; C07C53/10; C07C53/15; C07C53/16

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 63 words
A coordination complex of platinum having the formula: ##STR3## in which the R groups are the same or different and are selected from H and lower alkyl and X and Y are the same or different ligands selected from sulphate, phosphate, nitrate, acetate, chloroacetate and water, provided that X and Y are not both water, such that the platinum is present as Pt(II).
Claim 2
Dependent Claim 63 words
A coordination complex of platinum having the formula: ##STR3## in which the R groups are the same or different and are selected from H and lower alkyl and X and Y are the same or different ligands selected from sulphate, phosphate, nitrate, acetate, chloroacetate and water, provided that X and Y are not both water, such that the platinum is present as Pt(II).
Claim 3
Dependent Claim 21 words
A pharmaceutical composition comprising an effective amount of a compound according to claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 4
Dependent Claim 13 words
A compound selected from the group consisting of aquosulphato(N,N'-diethylethylenediamine)platinum (II) and bis(chloroacetato)-(N-ethylethylenediamine)platinum (II).
Claim 5
Dependent Claim 13 words
A compound selected from the group consisting of aquosulphato(N,N'-diethylethylenediamine)platinum (II) and bis(chloroacetato)-(N-ethylethylenediamine)platinum (II).

References Cited (Backward Citations)

US4140707A Cited
US4140707B1 Cited
US4119654A Cited
US4119653A Cited
US4115418A Cited
US4137248A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1984-02-10 1984-08-11 1985-02-10 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1988-02-10 1988-08-11 1989-02-10 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1992-02-10 1992-08-11 1993-02-10 $7700.00 Window Closed / Lapsed

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