US4137248A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Compound, 4-carboxyphthalato(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof
Assignee: United States Department of Health and Human Services
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Filing: 1977-08-29
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Granted: 1979-01-30
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Expires: 1997-08-29
Abstract
Abstract <IMAGE> <IMAGE> +TR <IMAGE> 4-Carboxyphthalato (1,2-diaminocyclohexane)platinum(II) (and alkali metal salts thereof) has shown antileukemic activity in mice against murine leukemia L1210. It is effective in dosages of 5-60 mg/kg of body weight and is potentiated in a treatment with cyclophosphamide (CY) (50 mg/kg of body weight) to which may be added 5-fluorouracil (5-FU) (75 mg/kg of body weight) or hydroxyurea (HU) (1000 mg/kg of body weight). Some previous platinum chelate compounds show dosage limitation due to renal impairment but the free carboxyl of the present Pt compound offers a possible route of oral administration and absorption by the stomach.
Inventors
- 👤 Glen R. Gale
- 👤 Paul Schwartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 07:29
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
7 words
##STR6## 4-carboxyphthalato(1,2-diaminocyclohexane)platinum(II) and alkali metal salts thereof.
Claim 2
Dependent Claim
7 words
##STR6## 4-carboxyphthalato(1,2-diaminocyclohexane)platinum(II) and alkali metal salts thereof.
References Cited (Backward Citations)
US3892790A
Cited
US3904663A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-29 | 1982-07-31 | 1983-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-29 | 1986-07-31 | 1987-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-29 | 1990-07-31 | 1991-01-30 | $7700.00 | Window Closed / Lapsed |