Patent US2887945A successfully refreshed from Google Patents.
Patent US4755461A successfully refreshed from Google Patents.
US4755461A
Expired / Lapsed
US
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Tableted blood plasma microconcentrated thromboplastin coagulation reagent
Assignee: Bio Data Corp
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Filing: 1986-04-17
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Granted: 1988-07-05
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Expires: 2006-04-17
Abstract
Abstract The invention herein is directed to an improved thromboplastin composition wherein the thromboplastin is supplied in a tablet separate from calcium salts in order to stabilize the thromboplastin.
Inventors
- 👤 Daniel E. Lawson
- 👤 Eugene J. Messa
- 👤 Michael Sokol
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 02:50
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/86; G01N2333/00; G01N2333/435; G01N2333/745; G01N2333/7454; G01N2405/00; G01N2405/04; Y; Y10; Y10S; Y10S435/00; Y10S435/81; Y10T; Y10T436/00; Y10T436/10; Y10T436/108331
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
46 words
An improved tableted microconcentrated blood plasma coagulation reagent which comprises a combination of a first tablet containing thromboplastin, a buffer, a binder, and a lubricant; and a second tablet containing a calcium salt selected from the group consisting of calcium lactate, calcium gluconate, and calcium chloride.
Claim 2
Dependent Claim
46 words
An improved tableted microconcentrated blood plasma coagulation reagent which comprises a combination of a first tablet containing thromboplastin, a buffer, a binder, and a lubricant; and a second tablet containing a calcium salt selected from the group consisting of calcium lactate, calcium gluconate, and calcium chloride.
Claim 3
Dependent Claim
18 words
The improved tableted reagent of claim 1 wherein the second tablet also contains a binder and a lubricant.
Claim 4
Dependent Claim
33 words
The improved tableted reagent of claim 2 wherein the binder is selected from the group consisting of glycine, sucrose, maltose, mannitol, lactose, and a mixture of about 97% sucrose and about 3% malto-dextrin.
Claim 5
Dependent Claim
21 words
The improved tableted reagent of claim 3 wherein the binder is a mixture of about 97% sucrose with about 3% malto-dextrin.
Claim 6
Dependent Claim
24 words
The improved tableted reagent of claim 2 wherein the lubricant is selected from the group consisting of polyethylene glycol, magnesium stearate, talc, and L-leucine.
Claim 7
Dependent Claim
12 words
The improved tableted reagent of claim 5 wherein the lubricant is L-leucine.
Claim 8
Dependent Claim
23 words
The improved tableted reagent of claim 1 wherein the buffer is selected from the group consisting of imidazole, tris, HEPES, glycine and barbitol.
Claim 9
Dependent Claim
27 words
The improved tableted reagent of claim 7 wherein the buffer is an imidazole/glycine mixture containing 0.05M imidazole, 2% glycine and having a pH at 6.8 to 7.5.
Claim 10
Dependent Claim
23 words
The improved tableted reagent of claim 1 wherein the binder is selected from the group consisting of trehalose, malto-dextrin, sugars, celluloses, and starches.
Claim 11
Dependent Claim
16 words
The improved tableted reagent of claim 9 wherein the binder is 97% sucrose and 3% malto-dextrin.
Claim 12
Dependent Claim
24 words
The improved tableted reagent of claim 1 wherein the lubricant is selected from the group consisting of polyethylene glycol, magnesium stearate, talc, and L-leucine.
Claim 13
Dependent Claim
12 words
The improved tableted reagent of claim 11 wherein the lubricant is L-leucine.
Claim 14
Dependent Claim
15 words
The improved tableted reagent of claim 1 wherein the first tablet contains an antimicrobial preservative.
Claim 15
Dependent Claim
13 words
The improved tableted reagent of claim 13 wherein the preservative is sodium azide.
Claim 16
Dependent Claim
25 words
The improved tableted reagent of claim 1 wherein the first tablet contains a stabilizer selected from the group consisting of manganese chloride or magnesium chloride.
Claim 17
Dependent Claim
14 words
The improved tableted reagent of claim 1 wherein first tablet contains a disintegrating agent.
Claim 18
Dependent Claim
40 words
The improved tableted reagent of claim 1 wherein the first tablet contains from about 50 to 75% by weight of buffer, from about 0.5 to 10% by weight of binder, and from about 1 to 15% by weight of lubricant.
Claim 19
Dependent Claim
18 words
The improved tableted reagent of claim 17 containing up to about 10% by weight of a disintegrating agent.
Claim 20
Dependent Claim
19 words
The improved tableted reagent of claim 17 containing from about 0.01 to 0.3% by weight of an antimicrobial preservative.
Claim 21
Dependent Claim
26 words
The improved tableted reagent of claim 17 containing from 0.005 to 0.02M of a stabilizer selected from the group consisting of manganese chloride or magnesium chloride.
Claim 22
Dependent Claim
40 words
The improved tableted reagent of claim 2 wherein the second tablet contains from about 15 to 85% by weight of calcium salt, from about 10 to 80% by weight of binder, and about 3 to 15% by weight of lubricant.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-05 | 1992-01-04 | 1992-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-05 | 1996-01-04 | 1996-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-05 | 2000-01-04 | 2000-07-05 | $7700.00 | Window Closed / Lapsed |