US3980432A
Expired / Lapsed
US
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Partial thromboplastin, its use as diagnostic agent and process for preparing it
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1975-07-28
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Granted: 1976-09-14
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Expires: 1995-07-28
Abstract
Abstract The present invention relates to a process for preparing partial thromboplastin which comprises extracting bloodless dry placentae with an organic solvent, separating the extract from the undissolved substance, evaporating, dispersing the residue in water and adding, if desired, a stabilizer and/or lyophilizing. It further relates to the partial thromboplastin thus obtained and to its use as diagnostic agent.
Inventors
- 👤 Heiner Trobisch
- 👤 Horst Schwinn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 02:46
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/48; A61K35/50; G; G01; G01N; G01N2333/00; G01N2333/435; G01N2333/745
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
81 words
A process for preparing a partial thromboplastin which comprises extracting bloodless dry comminuted placentas with an organic solvent selected from the group consisting of halogenated hydrocarbons and cyclic ethers in an amount from 20 to 100 times the weight of the placentas and at a temperature between room temperature and 80°C, separating the extract from the undissolved placental residue, evaporating the solvent from the extract, and dispersing the resulting residue in water to yield a concentration of 0.025 to 0.2 percent.
Claim 2
Dependent Claim
81 words
A process for preparing a partial thromboplastin which comprises extracting bloodless dry comminuted placentas with an organic solvent selected from the group consisting of halogenated hydrocarbons and cyclic ethers in an amount from 20 to 100 times the weight of the placentas and at a temperature between room temperature and 80°C, separating the extract from the undissolved placental residue, evaporating the solvent from the extract, and dispersing the resulting residue in water to yield a concentration of 0.025 to 0.2 percent.
Claim 3
Dependent Claim
10 words
Process of claim 1 wherein the organic solvent is chloroform.
Claim 4
Dependent Claim
10 words
Process of claim 1 wherein the organic solvent is tetrahydrofurane.
Claim 5
Dependent Claim
41 words
A process for preparing a partial thromboplastin which comprises adding a lipid dispersion stabilizing agent to the product of claim 1, said agent being selected from the group of carbohydrates, polyalcohols, buffer substances, antioxidants, and albumin, and then lyophilizing the mixture.
Claim 6
Dependent Claim
42 words
A process for preparing a diagnostic agent useful in the evaluation of disturbances of the coagulation system, which comprises dissolving the product of claim 4 in a 0.2 to 2 percent suspension of kaolin in an about 0.5 percent sodium chloride solution.
Claim 7
Dependent Claim
60 words
A process for the evaluation of the partial thromboplastin time, which comprises mixing one part by volume of the product of claim 5 with one part by volume of plasma, keeping the mixture for 2 minutes at 37° ± 0.5° C, subsequently adding one part by volume of a 0.025 molar calcium chloride solution and measuring the resulting clotting time.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-09-14 | 1980-03-15 | 1980-09-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-09-14 | 1984-03-15 | 1984-09-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-09-14 | 1988-03-15 | 1988-09-14 | $7700.00 | Window Closed / Lapsed |