Patent US4749689A successfully refreshed from Google Patents.
US4749689A
Expired / Lapsed
US
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Hemostatic agent composed of collagen/gelatin and protamine
Assignee: Koken Co Ltd
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Filing: 1987-08-17
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Granted: 1988-06-07
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Expires: 2007-08-17
Abstract
Abstract This invention relates to a hemostatic agent used in surgical operations, which can be produced in two ways: one blending collagen/gelatin with protamine, the other blending collagen/gelatin with protamine and a bi-functional cross-linking agent so as to make said collagen/gelatin have a covalent bond with said protamine. The produced hemostatic agent can stop bleeding within far less time than a conventional hemostatic agent made out of pure collagen.
Inventors
- 👤 Teruo Miyata
- 👤 Kazuhiko Kodaira
- 👤 Masayasu Furuse
- 👤 Yasuharu Noishiki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:15
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/07; A61L15/12; A61L15/125; A61K; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L26/00; A61L26/0009; A61L26/0052; A61L2400/00; A61L2400/04; Y; Y10; Y10S; Y10S128/00; Y10S128/08
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
21 words
A method of controlling bleeding comprising applying to a bleeding tissue a hemostatic agent composed of collagen or gelatin and protamine.
Claim 2
Independent Claim
21 words
A method of controlling bleeding comprising applying to a bleeding tissue a hemostatic agent composed of collagen or gelatin and protamine.
Claim 3
Dependent Claim
21 words
The method of claim 1 wherein said collagen or gelatin and protamine are covalently bonded together by a bifunctional crosslinking agent.
Claim 4
Dependent Claim
24 words
The method of claim 1 wherein said hemostatic agent is in the form of a sponge, a powder, a film or a dispersed solution.
Claim 5
Dependent Claim
13 words
The method of claim 1 wherein said hemostatic agent comprises collagen and protamine.
Claim 6
Dependent Claim
10 words
The method of claim 4 wherein said collagen is atelocollagen.
Claim 7
Dependent Claim
15 words
The method of claim 2 wherein said bifunctional crosslinking agent is glutaraldehyde or hexamethylene diisocyanate.
Claim 8
Dependent Claim
14 words
The method of claim 1 wherein said protamine is protamine sulfate or protamine hydrochloride.
Claim 9
Dependent Claim
16 words
The method of claim 1 wherein said bleeding is the result of injury or surgical operation.
Claim 10
Dependent Claim
26 words
The method of claim 8 wherein said bleeding is the result of a splenic injury and said hemostatic agent is applied directly to the splenic tissue.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-07 | 1991-12-07 | 1992-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-07 | 1995-12-07 | 1996-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-07 | 1999-12-07 | 2000-06-07 | $7700.00 | Window Closed / Lapsed |