US4749562A
Expired / Lapsed
US
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Dentifrice compositions
Assignee: CPPD Inc C/O CT Corp SYSTEM 208 LASALLE STREET CHICAGO ILLINOIS A CORP OF
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Filing: 1987-09-11
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Granted: 1988-06-07
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Expires: 2007-09-11
Abstract
Abstract It is disclosed that a dentifrice which includes a surfactant and an anti-plaque agent comprising a substantially water--insoluble non-cationic antimicrobial agent or a zinc salt or a mixture thereof has enhanced activity when the dentifrice comprises at least 0.2% by weight of a lamellar liquid crystal surfactant phase having a lamellar spacing of less than 6.0 nm.
Inventors
- 👤 Roger M. Lane
- 👤 Derek M. C. Hull
- 👤 Charles A. Saxton
- 👤 Franciscus J. G. van der Ouderaa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 13:34
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61K8/463; A61K8/02; A61K8/0295; A61K8/19; A61K8/27; A61K8/33; A61K8/34; A61K8/347; A61K8/36; A61K8/365; A61Q; A61Q11/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
206 words
Process of inhibiting plaque growth comprising: mixing water, a surfactant and anti-plaque agent to form a dentifrice composition, said anti-plaque agent being a substantially water-insoluble non-cationic antimicrobial agent present in an amount effective to inhibit plaque growth, a zinc salt having a water solubility greater than 2×10 -4 per 100 g of water at 25° and pH 7, or a mixture of the anti-microbial agent and the zinc salts; forming a lamellar liquid crystal surfactant phase in the composition, the lamellar liquid crystal surfactant phase comprising at least 0.2% of the composition; adjusting the lamellar spacing of the lamellar liquid crystal surfactant phase to less than 6.0 nm; and delivering the composition to tooth surfaces, the lamellar spacing and percentage by weight of the lamellar liquid crystal surfactant phase being measured after a centrifugation separation procedure, said procedure comprising: (1) sufficient centrifugation to separate the dentifrice composition into its main phase including a liquid portion; followed by (2) sufficient ultracentrifugation of the liquid portion so that the liquid portion separates into layers until there is no substantial change in volumes of the separated layers of the liquid portion, the lamellar liquid crystal surfactant phase being present as one of the separated layers of the liquid portion.
Claim 2
Dependent Claim
206 words
Process of inhibiting plaque growth comprising: mixing water, a surfactant and anti-plaque agent to form a dentifrice composition, said anti-plaque agent being a substantially water-insoluble non-cationic antimicrobial agent present in an amount effective to inhibit plaque growth, a zinc salt having a water solubility greater than 2×10 -4 per 100 g of water at 25° and pH 7, or a mixture of the anti-microbial agent and the zinc salts; forming a lamellar liquid crystal surfactant phase in the composition, the lamellar liquid crystal surfactant phase comprising at least 0.2% of the composition; adjusting the lamellar spacing of the lamellar liquid crystal surfactant phase to less than 6.0 nm; and delivering the composition to tooth surfaces, the lamellar spacing and percentage by weight of the lamellar liquid crystal surfactant phase being measured after a centrifugation separation procedure, said procedure comprising: (1) sufficient centrifugation to separate the dentifrice composition into its main phase including a liquid portion; followed by (2) sufficient ultracentrifugation of the liquid portion so that the liquid portion separates into layers until there is no substantial change in volumes of the separated layers of the liquid portion, the lamellar liquid crystal surfactant phase being present as one of the separated layers of the liquid portion.
Claim 3
Dependent Claim
27 words
Process as claimed in claim 1 comprising forming a lamellar liquid crystal surfactant phase by combining the surfactant and sorbitol in the presence of a flavor oil.
Claim 4
Dependent Claim
32 words
Process as claimed in claim 2 comprising combining the surfactant with about 15% to about 70% by weight of sorbitol syrup and about 0.1% to about 5% by weight of flavor oil.
Claim 5
Dependent Claim
57 words
Process as claimed in claim 1 comprising adjusting the lamellar spacing to less than 6.0 nm by adding to the composition a water-soluble salt, other than a fluorine-containing salt, in an amount providing a molar cation concentration equal to the molar cation concentration provided by about 0.1% to about 3% sodium chloride by weight of the composition.
Claim 6
Dependent Claim
16 words
Process as claimed in claim 1 comprising delivering the composition to tooth surfaces by tooth brushing.
Claim 7
Dependent Claim
167 words
Process for making a dentifrice composition effective to inhibit the growth of dental plaque which comprises a surfactant, a particulate abrasive agent, water, an anti-plaque agent consisting of an effective amount of a substantially water-insoluble non-cationic antimicrobial agent, a zinc salt having a water solubility greater than 2×10 -4 per 100 g of water at 25? C. and pH 7, or a mixture thereof; and a water-soluble salt other than a fluorine-containing salt in an amount providing a molar cation concentration equal to the molar cation concentration provided by about 0.1% to about 0.3% sodium chloride by weight of the dentifrice composition; the process of making the composition comprising mixing said water-soluble salt with the surfactant, abrasive, water and anti-plaque agent so as to result in an aqueous phase having an electrolyte concentration sufficient to result in the formation of a lamellar liquid crystal surfactant phase having lamellar spacing of less than 6.0 nm in an amount of at least about 0.2% by weight of the composition.
Claim 8
Dependent Claim
167 words
Process for making a dentifrice composition effective to inhibit the growth of dental plaque which comprises a surfactant, a particulate abrasive agent, water, an anti-plaque agent consisting of an effective amount of a substantially water-insoluble non-cationic antimicrobial agent, a zinc salt having a water solubility greater than 2×10 -4 per 100 g of water at 25? C. and pH 7, or a mixture thereof; and a water-soluble salt other than a fluorine-containing salt in an amount providing a molar cation concentration equal to the molar cation concentration provided by about 0.1% to about 0.3% sodium chloride by weight of the dentifrice composition; the process of making the composition comprising mixing said water-soluble salt with the surfactant, abrasive, water and anti-plaque agent so as to result in an aqueous phase having an electrolyte concentration sufficient to result in the formation of a lamellar liquid crystal surfactant phase having lamellar spacing of less than 6.0 nm in an amount of at least about 0.2% by weight of the composition.
Claim 9
Dependent Claim
30 words
A process according to claim 6 further comprising mixing the water-soluble salt with the surfactant, abrasive, water and anti-plaque agent at a temperature within the range 15° to 35° C.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-06-07 | 1991-12-07 | 1992-06-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-06-07 | 1995-12-07 | 1996-06-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-06-07 | 1999-12-07 | 2000-06-07 | $7700.00 | Window Closed / Lapsed |