Patent US3014676A successfully refreshed from Google Patents.
Patent US4732686A successfully refreshed from Google Patents.
US4732686A
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Weak eluant ion chromatography
Assignee: Dow Chemical Co
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Filing: 1985-12-19
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Granted: 1988-03-22
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Expires: 2005-12-19
Abstract
Abstract Apparatus and method for the chromatographic separation and analysis of ionic species. This process is carried out utilizing, in an ion separator column, the combination of a low capacity, high performance resin as the stationary phase, and a weakly ionized electrolyte as the eluant or developing reagent, to effect resolution of ionic species in solution. For anion separation, a weak base resin of low capacity and high efficiency is used as the stationary phase, and a solution of a weak base or water as the mobile phase. For cation separation, a weak acid resin of low capacity and high efficiency is used as the stationary phase and a solution of a weak acid as the mobile phase. Because the eluant employed has a very low background conductivity, it will register only insignificantly on the readout from the conductivity cell. Thus, the method of the invention obviates the need for the eluant suppressor or "stripper" device used in conventional ion chromatography. The invention thereby enables continuous, uninterrupted measurements and eliminates the reservoirs, pumps, complex valving and electronics associated with such suppressor columns.
Inventors
- 👤 Hamish Small
- 👤 Mark E. Soderquist
- 👤 James W. Pischke
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 07:28
CPC Classifications
G; G01; G01N; G01N30/00; G01N30/96
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
223 words
A method for eliminating the need for an eluant suppressor device in the chromatographic separation and detection of ionic species present in solution, each of the species being of the same valence sign, said method comprising: supporting in a column for ion separation, a resin bed including chromatographic resin comprising a low capacity, high-performance stationary phase for controlled interaction with ionic species to be introduced into the column, introducing into the column a solution containing ionic species to be separated and analyzed, introducing into the column a solution of developing reagent of weakly ionized electrolytes selected from the group consisting of water, pyridine, H 2 CO 3 , and mixtures thereof for eluting ionic species present in the column, regulating solution flow through the column and passing the solution containing the ionic species and the solution of the developing reagent through the column and through the resin contained therein, eluting the ionic species with the solution and effecting a resolution of and chromatographic separation of the ionic species as the species traverse a flow path through the column, sensing and detecting ionic species passing through the resin bed and delivered from the column, providing visually perceptable indicia correlated with specific ionic species emanating with an effluent solution discharged from the column, and identifying ionic species in the effluent solution discharged from the column.
Claim 2
Independent Claim
223 words
A method for eliminating the need for an eluant suppressor device in the chromatographic separation and detection of ionic species present in solution, each of the species being of the same valence sign, said method comprising: supporting in a column for ion separation, a resin bed including chromatographic resin comprising a low capacity, high-performance stationary phase for controlled interaction with ionic species to be introduced into the column, introducing into the column a solution containing ionic species to be separated and analyzed, introducing into the column a solution of developing reagent of weakly ionized electrolytes selected from the group consisting of water, pyridine, H 2 CO 3 , and mixtures thereof for eluting ionic species present in the column, regulating solution flow through the column and passing the solution containing the ionic species and the solution of the developing reagent through the column and through the resin contained therein, eluting the ionic species with the solution and effecting a resolution of and chromatographic separation of the ionic species as the species traverse a flow path through the column, sensing and detecting ionic species passing through the resin bed and delivered from the column, providing visually perceptable indicia correlated with specific ionic species emanating with an effluent solution discharged from the column, and identifying ionic species in the effluent solution discharged from the column.
Claim 3
Dependent Claim
17 words
The method as set forth in claim 1 wherein said solution of developing reagent means is water.
Claim 4
Dependent Claim
208 words
In the method of chromatographic analysis of a plurality of species of ions in sample solutions and including the steps of introducing into a separator column A a sample solution containing ionic species of interest, containing a resin bed including an ion exchange resin, adding a developing solution to the sample-containing separator column to resolve ionic species present in the sample solution and to elute the ionic species from the resin bed of the column separator for conductivly detecting the separated ionic species carried through the resin and delivered from the separator column, and for producing visually perceptible indicia of the ionic species, the improvement wherein the resin in the resin bed comprises a low capacity, high-performance stationary phase retained in the separator column, and wherein the developing solution for eluting the ionic species of the sample solution comprises a solution of a weakly ionized electrolytes selected from the group consisting of water, pyridine, H 2 CO 3 , and mixtures thereof, said improvement being characterized in effectively obviating the need for an eluant suppressor column of the type conventionally used for substituting ions of lesser conductivity for highly conductive ions which are ordinarily contained in the eluant and which interfer with conductive detection of ions of interest.
Claim 5
Dependent Claim
208 words
In the method of chromatographic analysis of a plurality of species of ions in sample solutions and including the steps of introducing into a separator column A a sample solution containing ionic species of interest, containing a resin bed including an ion exchange resin, adding a developing solution to the sample-containing separator column to resolve ionic species present in the sample solution and to elute the ionic species from the resin bed of the column separator for conductivly detecting the separated ionic species carried through the resin and delivered from the separator column, and for producing visually perceptible indicia of the ionic species, the improvement wherein the resin in the resin bed comprises a low capacity, high-performance stationary phase retained in the separator column, and wherein the developing solution for eluting the ionic species of the sample solution comprises a solution of a weakly ionized electrolytes selected from the group consisting of water, pyridine, H 2 CO 3 , and mixtures thereof, said improvement being characterized in effectively obviating the need for an eluant suppressor column of the type conventionally used for substituting ions of lesser conductivity for highly conductive ions which are ordinarily contained in the eluant and which interfer with conductive detection of ions of interest.
Claim 6
Dependent Claim
31 words
The improvement as set forth in claim 3 wherein the ionic species are anions, the resin is a weak base resin, and the eluant is a dilute aqueous solution of pyridine.
Claim 7
Dependent Claim
34 words
The improvement as set forth in claim 3 wherein the ionic species are cations, the resin is a weak acid resin, and the eluant is a dilute solution of H 2 CO 3 .
Claim 8
Dependent Claim
14 words
The improvement as set forth in claim 3 wherein said developing solution is water.
References Cited (Backward Citations)
US3915642A
Cited
US3925019A
Cited
US4039442A
Cited
US4009998A
Cited
US4303531A
Cited
US4303531B1
Cited
US4272246A
Cited
JPS56144705A
Cited
US4455233A
Cited
US4556463A
Cited
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