Patent US4728509A successfully refreshed from Google Patents.
US4728509A
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Aqueous liquid preparation
Assignee: Senju Pharmaceutical Co Ltd
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Filing: 1986-08-05
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Granted: 1988-03-01
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Expires: 2006-08-05
Abstract
Abstract In the aqueous liquid preparation of this invention, which comprises a compound of the formula; ##STR1## wherein R is an alkyl having 1-6 carbon atoms, and at least one species of the solubilizers selected from the group consisting of polyvinylpyrrolidone, cyclodextrin and caffeine, the solubility of the compound in water can be heightened and the aqueous liquid prepared thereby can afford a desired stability and mitigate eye-irritation or nose-irritation.
Inventors
- 👤 Hisayoshi Shimizu
- 👤 Mitsuaki Oshima
- 👤 Hideo Terayama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 12:44
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/455; A61K47/00; A61K47/06; A61K47/22; A61K47/30; A61K47/32; A61K47/36; A61K47/40; A61P; A61P27/00; A61P27/02; A61P27/14; A61P27/16; A61P29/00; A61P37/00; A61P37/08
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
62 words
An aqueous liquid composition, which comprises a therapeutically effective amount of a compound of the formula; ##STR3## wherein R is an alkyl having 1-6 carbon atoms, and at least one solubilizer selected from the group consisting of polyvinylpyrrolidone in an amount of about 0.2-20% (W/V), cyclodextrin in an amount of about 0.2-5% (W/V), and caffeine in an amount of about 0.1-2% (W/V).
Claim 2
Dependent Claim
62 words
An aqueous liquid composition, which comprises a therapeutically effective amount of a compound of the formula; ##STR3## wherein R is an alkyl having 1-6 carbon atoms, and at least one solubilizer selected from the group consisting of polyvinylpyrrolidone in an amount of about 0.2-20% (W/V), cyclodextrin in an amount of about 0.2-5% (W/V), and caffeine in an amount of about 0.1-2% (W/V).
Claim 3
Dependent Claim
17 words
An aqueous liquid composition as claimed in claim 1, wherein the preparation is for a nasal drop.
Claim 4
Dependent Claim
17 words
An aqueous liquid composition as claimed in claim 1, wherein the preparation is for an eye drop.
Claim 5
Dependent Claim
18 words
An aqueous liquid composition as claimed in claim 1, wherein the preparation is further incorporated with boric acid.
Claim 6
Dependent Claim
14 words
An aqueous liquid composition as claimed in claim 1, wherein the solubilizer is polyvinylpyrrolidone.
Claim 7
Dependent Claim
14 words
An aqueous liquid composition as claimed in claim 1, wherein the solubilizer is cyclodextrin.
Claim 8
Dependent Claim
14 words
An aqueous liquid composition as claimed in claim 1, wherein the solubilizer is caffeine.
Claim 9
Dependent Claim
15 words
An aqueous liquid composition as claimed in claim 1, wherein the compound is 2-amino-7-isopropyl-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid.
Claim 10
Dependent Claim
21 words
An aqueous liquid composition as claimed in claim 5 wherein the polyvinylpyrrolidone is present in an amount of about 0.5-15% (W/V).
Claim 11
Dependent Claim
21 words
An aqueous liquid composition as claimed in claim 5 wherein the polyvinylpyrrolidone is present in an amount of about 10-10% (W/V).
Claim 12
Dependent Claim
21 words
An aqueous liquid composition as claimed in claim 6 wherein the cyclodextrin is present in an amount of about 0.5-2% (W/V).
Claim 13
Dependent Claim
21 words
An aqueous liquid composition as claimed in claim 7 wherein the caffeine is present in an amount of about 0.2-1.0% (W/V).
References Cited (Backward Citations)
DD7498A1
Cited
US3927205A
Cited
US4143042A
Cited
JPS54115398A
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US4344968A
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EP0082921A1
Cited
EP0094157A1
Cited
US4539326A
Cited
EP0105635A2
Cited
EP0119737A2
Cited
EP0191568A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-03-01 | 1991-08-31 | 1992-03-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-03-01 | 1995-08-31 | 1996-03-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-03-01 | 1999-08-31 | 2000-03-01 | $7700.00 | Window Closed / Lapsed |