EP0082921A1
Expired / Lapsed
EP
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Anti-inflammatory ophthalmic solution and process for preparing the same
Assignee: Kaken Pharmaceutical Co Ltd
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Filing: 1982-08-24
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Granted: —
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Expires: 2002-08-24
Abstract
Abstract An anti-inflammatory ophthalmic solution containing (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) β-cyclodextrin or y-cyclodextrin. The ophthalmic solution makes easy operations conducted for diseases in ophthalmic region, and is useful for early recovery or reduction of inflammation by pre-and post-operative topical instillation thereof or by intraocular perfusion with a perfusate to which the ophthalmic solution is added, or for treatment of inflammatory eye diseases.
Inventors
- 👤 Kiyoshi Masuda
- 👤 Takashi Ikari
- 👤 Takashi Matsuyama
- 👤 Akio Terashima
- 👤 Takao Goto
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-29 19:51
CPC Classifications
B; B82; B82Y; B82Y5/00; A; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K47/00; A61K47/30; A61K47/36; A61K47/40; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
26 words
An anti-inflammatory ophthalmic solution comprising effective amounts of (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) β-cyclodextrin or 7 -cyclodextrin in an aqueous medium.
Claim 2
Dependent Claim
26 words
An anti-inflammatory ophthalmic solution comprising effective amounts of (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) β-cyclodextrin or 7 -cyclodextrin in an aqueous medium.
Claim 3
Dependent Claim
28 words
The anti-inflammatory ophthalmic solution of Claim 1, wherein the molar ratio of the component (A) to the component (B) is from 1 : 0.5 to 1 : 2.5.
Claim 4
Dependent Claim
23 words
The anti-inflammatory ophthalmic solution of Claim 1 or 2, wherein the concentration of the component (A) is from 0.001 to 2 w/v %.
Claim 5
Dependent Claim
13 words
The anti-inflammatory ophthalmic solution of Claim 1, which further contains a viscosity-inducing agent.
Claim 6
Dependent Claim
19 words
The anti-inflammatory ophthalmic solution of Claim 1, which is adjusted to pH 5.0 to 8.0 with a buffer agent.
Claim 7
Dependent Claim
30 words
A process for preparing an anti-inflammatory ophthalmic solution which comprises adding and dissolving (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) 0-cyclodextrin or γ-cyclodextrin to an aqueous medium.
Claim 8
Dependent Claim
30 words
A process for preparing an anti-inflammatory ophthalmic solution which comprises adding and dissolving (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt and (B) 0-cyclodextrin or γ-cyclodextrin to an aqueous medium.
Claim 9
Dependent Claim
38 words
The process of Claim 6, wherein the component (A) and the component (B) are added in such amounts that the component (A) is present in a concentration of 0.001 to 2 w/v % in the obtained ophthalmic solution.
Claim 10
Dependent Claim
29 words
The process of Claim 6 or 7, wherein the component (A) and the component (B) are added in a molar ratio of 1 : 0.5 to 1 : 2.5.
Claim 11
Dependent Claim
12 words
The process of Claim 6, wherein a viscosity-inducing agent is further added.
Claim 12
Dependent Claim
20 words
The process of Claim 6, wherein the aqueous medium is adjusted to pH 5.0 to 8.0 with a buffer agent.
Claim 13
Dependent Claim
35 words
A process for preparing an anti-inflammatory ophthalmic solution which comprises adding and dissolving an inclusion complex of (A) 2-(2-fluoro-4-biphenylyl)-propionic acid or its ophthalmologically acceptable salt with (B) β-cyclodextrin or 7 -cyclodextrin to an aqueous medium.
Claim 14
Dependent Claim
35 words
A process for preparing an anti-inflammatory ophthalmic solution which comprises adding and dissolving an inclusion complex of (A) 2-(2-fluoro-4-biphenylyl)-propionic acid or its ophthalmologically acceptable salt with (B) β-cyclodextrin or 7 -cyclodextrin to an aqueous medium.
Claim 15
Dependent Claim
35 words
The process of Claim 11, wherein the inclusion complex is added in such an amount that the component (A) is present in a concentration of 0.001 to 2 w/v % in the obtained ophthalmic solution.
Claim 16
Dependent Claim
33 words
The process of Claim 11 or 12, wherein the molar ratio of the component (A) to the component (B) in the inclusion complex used is from 1 : 0.5 to 1 : 2.5.
Claim 17
Dependent Claim
12 words
The process of Claim 11, wherein a viscosity-inducing agent is further added.
Claim 18
Dependent Claim
20 words
The process of Claim 11, wherein the aqueous medium is adjusted to pH 5.0 to 8.0 with a buffer agent.
Claim 19
Dependent Claim
43 words
A process for preparing an anti-inflammatory ophthalmic solution which comprises adding and dissolving (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt, (B) β-cyclodextrin or 7 -cyclodextrin and (C) an inclusion complex of the component (A) with the component (B) to an aqueous medium.
Claim 20
Dependent Claim
43 words
A process for preparing an anti-inflammatory ophthalmic solution which comprises adding and dissolving (A) 2-(2-fluoro-4-biphenylyl)propionic acid or its ophthalmologically acceptable salt, (B) β-cyclodextrin or 7 -cyclodextrin and (C) an inclusion complex of the component (A) with the component (B) to an aqueous medium.
Claim 21
Dependent Claim
40 words
The process of Claim 16, wherein the component (A), the component (B) and component (C) are added in such amounts that the component (A) is present in a concentration of 0.001 to 2 w/v % in the obtained ophthalmic solution.
Claim 22
Dependent Claim
50 words
The process of Claim 16 or 17, wherein the component (A), the component (B) and the component (C) are added in such amounts that the component (A) and the component (B) are present in a molar ratio of 1 : 0.5 to 1 : 2.5 in the obtained ophthalmic solution.
Claim 23
Dependent Claim
12 words
The process of Claim 16, wherein a viscosity-inducing agent is further added.
Claim 24
Dependent Claim
20 words
The process of Claim 16, wherein the aqueous medium is adjusted to pH 5.0 to 8.0 with a buffer agent.
References Cited (Backward Citations)
US4230724A
Cited
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