US4724145A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Eimeria acervulina immunogens
Assignee: Merck and Co Inc
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Filing: 1985-11-18
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Granted: 1988-02-09
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Expires: 2005-11-18
Abstract
Abstract High levels of immunity are achieved in chickens inoculated intramuscularly or orally with E. acervulina extract immunogens. These extracts contain at least 20 polypeptides which induce a protective immune response not only against E. acervulina but also against E. tenella and E. maxima. The resulting immunity prevents intestinal lesions and reduces the number of viable oocysts in vaccinated and challenged birds. One or more of these polypeptides can be used as an immunogen to protect against coccidiosis.
Inventors
- 👤 Peter K. Murray
- 👤 Balbir S. Bhogal
- 👤 Ethel B. Jacobson
- 👤 Mark S. Crane
- 👤 Dennis M. Schmatz
- 👤 Stefan Galuska
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 02:31
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/44; C07K14/455; A; A61; A61K; A61K39/00; A61K39/002; A61K39/012; Y; Y10; Y10S; Y10S435/00; Y10S435/803; Y10S435/8215; Y10S435/947; Y10S530/00; Y10S530/82; Y10S530/822
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
35 words
An immunogenic composite obtained from Eimeria acervulina sporulated oocysts by grinding, collecting the supernatant fluid by centrifugation, freezing and thawing the supernatant fluid and sonicating the supernatant fluid which is capable of immunizing against coccidiosis.
Claim 2
Dependent Claim
35 words
An immunogenic composite obtained from Eimeria acervulina sporulated oocysts by grinding, collecting the supernatant fluid by centrifugation, freezing and thawing the supernatant fluid and sonicating the supernatant fluid which is capable of immunizing against coccidiosis.
Claim 3
Dependent Claim
20 words
A method of immunizing chickens against coccidiosis comprising administering an effective immunizing amount of the immunogenic composite of claim 1.
Claim 4
Dependent Claim
29 words
An immunizing composition for confering on chickens active immunity against coccidiosis which comprises an effective immunizing amount of the immunogenic composite of claim 1 in a physiologically acceptable medium.
Claim 5
Dependent Claim
22 words
A sporozoite immunogen obtained by disrupting a suspension of Eimeria acervulina sporozoites, the disrupted material containing polypeptides capable of immunizing against coccidiosis.
Claim 6
Dependent Claim
22 words
A sporozoite immunogen obtained by disrupting a suspension of Eimeria acervulina sporozoites, the disrupted material containing polypeptides capable of immunizing against coccidiosis.
Claim 7
Dependent Claim
44 words
The sporozoite immunogen of claim 4 having immunogenic polypeptides having molecular weights of 115, 84, 74, 68, 65, 59, 45, 41.5, 37, 34, 31, 29, 27, 26.5, 26, 24, 23, 22.5, 21.5 and 20 kd against which polyclonal antibodies specific to Eimeria acervulina react.
Claim 8
Dependent Claim
20 words
A method of immunizing chickens against coccidiosis comprising administrating an effective immunizing amount of the sporozoite immunogen of claim 4.
Claim 9
Dependent Claim
25 words
A sporozoite immunogen composition capable of protecting against coccidiosis comprising an effective amount of the sporozoite immunogen of claim 5 in a physiologically acceptable medium.
Claim 10
Dependent Claim
24 words
A composition according to claim 7 wherein the sporozoite immunogen is present in an amount of from about 1 μg to about 200 μg.
Claim 11
Dependent Claim
24 words
A composition according to claim 8 wherein the sporozoite immunogen is present in an amount of from about 5 μg to about 75 μg.
References Cited (Backward Citations)
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US4650676A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1991-02-08 | 1991-08-10 | 1992-02-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-02-08 | 1995-08-10 | 1996-02-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-02-08 | 1999-08-10 | 2000-02-09 | $7700.00 | Window Closed / Lapsed |