Patent US4681894A successfully refreshed from Google Patents.
US4681894A
Expired / Lapsed
US
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Hydroxamic acids and esters
Assignee: Ortho Pharmaceutical Corp
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Filing: 1986-09-26
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Granted: 1987-07-21
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Expires: 2006-09-26
Abstract
Abstract The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.
Inventors
- 👤 William V. Murray
- 👤 Michael P. Wachter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 01:35
CPC Classifications
C; C07; C07C; C07C259/00; C07C259/04; C07C259/06; C07C59/00; C07C59/40; C07C59/76; C07C59/90; A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61P; A61P1/00; A61P11/00; A61P17/00; A61P29/00; A61P37/00; A61P37/08; A61P43/00; A61P9/00; A61P9/10; Y; Y10; Y10S; Y10S424/00; Y10S424/81
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
110 words
A compound of the formula ##STR6## where R 1 is C 1-12 alkyl, C 3-12 branched-chain alkyl, C 2-6 alkenyl, C 3-6 alkynyl or aralkyl wherein the alkyl group of the aralkyl is a C 1-3 alkyl and wherein the aralkyl group is unsubstituted or substituted with a C 1-2 alkyl or hydroxyalkyl wherein the alkyl group is C 1-6 ; R 2 is H, C 1-10 alkyl, C 3-10 branched-chain alkyl, C 5-7 cycloalkyl, phenyl or phenyl substituted with C 1-3 alkyl or C 1-3 alkoxy; R 3 is H or C 1-3 alkyl; and (CH 2 ) n is a straight- or branched-alkyl chain wherein n is 0-5.
Claim 2
Dependent Claim
110 words
A compound of the formula ##STR6## where R 1 is C 1-12 alkyl, C 3-12 branched-chain alkyl, C 2-6 alkenyl, C 3-6 alkynyl or aralkyl wherein the alkyl group of the aralkyl is a C 1-3 alkyl and wherein the aralkyl group is unsubstituted or substituted with a C 1-2 alkyl or hydroxyalkyl wherein the alkyl group is C 1-6 ; R 2 is H, C 1-10 alkyl, C 3-10 branched-chain alkyl, C 5-7 cycloalkyl, phenyl or phenyl substituted with C 1-3 alkyl or C 1-3 alkoxy; R 3 is H or C 1-3 alkyl; and (CH 2 ) n is a straight- or branched-alkyl chain wherein n is 0-5.
Claim 3
Dependent Claim
12 words
A compound of claim 1 wherein R 1 is CH 3 .
Claim 4
Dependent Claim
20 words
A compound of claim 1 wherein R 2 is H, C 1-6 alkyl, C 3-4 branched-chain alkyl, cyclohexyl or phenyl.
Claim 5
Dependent Claim
14 words
A compound of claim 1 wherein R 3 is H or CH 3 .
Claim 6
Dependent Claim
37 words
A compound of claim 1 wherein R 1 is CH 3 , R 2 is CH(CH 3 ) 2 or phenyl, R 3 is H and (CH 2 ) n is a straight-alkyl chain of 2 carbons.
Claim 7
Dependent Claim
30 words
A compound of claim 1 wherein R 1 , R 2 and R 3 are each CH 3 and (CH 2 ) n is a straight-alkyl chain of 2 carbons.
Claim 8
Dependent Claim
18 words
A compound of claim 1 selected from the group consisting of N-hydroxy-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; N-ethyl-N-hydroxy-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; N-butyl-N-hydroxy-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; N-heptyl-N-hydroxy-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; N-tert-butyl-N-hydroxy-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; and N-hydroxy-N-cyclohexyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide.
Claim 9
Dependent Claim
16 words
A compound of claim 1 selected from the group consisting of N-hydroxy-N-methyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; N-hydroxy-N-phenyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; N-methoxy-N-methyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide; and N-hydroxy-N-isopropyl-6-(6-methoxy-2-naphthyl)-6-oxohexanamide.
Claim 10
Dependent Claim
31 words
A pharmaceutical composition for topical, oral, parenteral and aerosol administration, comprising an effective amount of a compound according to claim 1 as the active ingredient dispersed in a pharmaceutically acceptable carrier.
Claim 11
Dependent Claim
35 words
The pharmaceutical composition according to claim 9 wherein said compound is capable of inhibiting both the cyclooxygenase and lipoxygenase pathways in the amount present in the composition when said composition is introduced into a mammal.
Claim 12
Dependent Claim
24 words
A method for alleviating inflammation in a mammal exhibiting an inflammatory response comprising administering to said mammal a pharmaceutical composition according to claim 9.
Claim 13
Dependent Claim
28 words
A method for treating inflammatory conditions of the skin in a mammal, including psoriasis and dermatitis, comprising administering to said mammal a pharmaceutical composition according to claim 9.
Claim 14
Dependent Claim
28 words
A method for treating asthma and allergic hypersensitivity diseases in a mammal comprising administering to said mammal an effective amount of a pharmaceutical composition according to claim 9.
Claim 15
Dependent Claim
33 words
A method for treating cardiovascular disorders in a mammal involving products of the cyclooxygenase and/or lipoxygenase pathways comprising administering to said mammal an effective amount of a pharmaceutical composition according to claim 9.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-20 | 1991-01-19 | 1991-07-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-20 | 1995-01-19 | 1995-07-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-20 | 1999-01-19 | 1999-07-21 | $7700.00 | Window Closed / Lapsed |