US4608390A
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Lipoxygenase inhibiting compounds
Assignee: Abbott Laboratories
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Filing: 1985-04-26
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Granted: 1986-08-26
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Expires: 2005-04-26
Abstract
Abstract Compounds of the formula ##STR1## where X is selected from hydrogen, C 1 to C 22 alkyl or alkenyl, or an electron withdrawing group; n=0 or 1 and m=0, 1, 2 or 3; but n and m are not O simultaneously; R 1 and R 2 independently are hydrogen, C 1 to C 6 alkyl, an electron withdrawing group, or R 4 ; R 3 is H, C 1 to C 6 alkyl or cycloalkyl, or R 4 ; and R 4 independently at each occurrence, has the formula ##STR2## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation, are potent inhibitors of lipoxygenase enzymes.
Inventors
- 👤 James B. Summers, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:17
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/16; A61K31/165; A61P; A61P11/00; A61P17/00; A61P29/00; A61P37/00; A61P37/08; A61P43/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
100 words
A compound of the formula ##STR10## where X is selected from hydrogen, C 1 to C 22 alkyl or alkenyl, or an electron withdrawing group; n is 1 and m=0, 1, 2 or 3; R 1 and R 2 independently are hydrogen, C 1 to C 6 alkyl, an electron withdrawing group, or R 4 ; R 3 is H, C 1 to C 6 alkyl or cycloalkyl, or R 4 ; and R 4 independently at each occurrence, has the formula ##STR11## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation.
Claim 2
Dependent Claim
100 words
A compound of the formula ##STR10## where X is selected from hydrogen, C 1 to C 22 alkyl or alkenyl, or an electron withdrawing group; n is 1 and m=0, 1, 2 or 3; R 1 and R 2 independently are hydrogen, C 1 to C 6 alkyl, an electron withdrawing group, or R 4 ; R 3 is H, C 1 to C 6 alkyl or cycloalkyl, or R 4 ; and R 4 independently at each occurrence, has the formula ##STR11## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 wherein m is 0.
Claim 4
Dependent Claim
16 words
A compound according to claim 2 wherein R 3 is C 1 to C 6 alkyl.
Claim 5
Dependent Claim
13 words
A compound according to claim 2 wherein R 3 is R 4 .
Claim 6
Dependent Claim
24 words
A compound according to claim 3 wherein R 1 and R 3 are C 1 to C 6 alkyl and R 2 is H.
Claim 7
Dependent Claim
24 words
A compound according to claim 3 wherein R 2 and R 3 are C 1 to C 6 alkyl and R 2 is H.
Claim 8
Dependent Claim
14 words
A compound according to claim 1 wherein n is O and M is 3.
Claim 9
Dependent Claim
36 words
A compound according to claim 1 wherein the pharmaceutically acceptable cation is a nontoxic cation selected from the group consisting of hydrogen, alkali metal cations, alkaline earth metal cations, and ammonium, quaternary ammonium and amine cations.
Claim 10
Dependent Claim
44 words
A method of inhibiting lipoxygenase activity in a human or lower animal host in need of such treatment, comprising administering to the human or lower animal host a compound according to claim 1 in an amount effective to inhibit lipoxygenase activity in the host.
Claim 11
Dependent Claim
15 words
A method according to claim 9 wherein the compound is administered orally, parenterally, or topically.
Claim 12
Dependent Claim
24 words
A method according to claim 10 wherein the compound is administered at a dosage of from 0.001 to 100 mg/kg body weight per day.
Claim 13
Dependent Claim
24 words
A method according to claim 11 wherein the compound is administered at a dosage of from 0.01 to 10 mg/kg body weight per day.
Claim 14
Dependent Claim
31 words
A composition in unit dosage form for the inhibition of lipoxygenase activity in a human or lower animal host, comprising a compound according to claim 1 and a pharmaceutical carrier material.
Claim 15
Dependent Claim
107 words
A compound of the formula ##STR12## where X is selected from hydrogen, C 1 to C 22 alkyl or alkenyl, or an electron withdrawing group; n=0 or 1 and m=0, 1, 2 or 3, but n and m are not 0 simultaneously; R 1 and R 2 independently are hydrogen, C 1 to C 6 alkyl, an electron withdrawing group, or R 4 ; R 3 is C 1 to C 6 alkyl or cycloalkyl, or R 4 ; and R 4 independently at each occurrence, has the formula ##STR13## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation.
Claim 16
Dependent Claim
107 words
A compound of the formula ##STR12## where X is selected from hydrogen, C 1 to C 22 alkyl or alkenyl, or an electron withdrawing group; n=0 or 1 and m=0, 1, 2 or 3, but n and m are not 0 simultaneously; R 1 and R 2 independently are hydrogen, C 1 to C 6 alkyl, an electron withdrawing group, or R 4 ; R 3 is C 1 to C 6 alkyl or cycloalkyl, or R 4 ; and R 4 independently at each occurrence, has the formula ##STR13## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation.
Claim 17
Dependent Claim
14 words
A compound according to claim 14 wherein n is 1 and m is 0.
Claim 18
Dependent Claim
16 words
A compound according to claim 15 wherein R 3 is C 1 to C 6 alkyl.
Claim 19
Dependent Claim
13 words
A compound according to claim 15 wherein R 3 is R 4 .
Claim 20
Dependent Claim
24 words
A compound according to claim 16 wherein R 1 and R 3 are C 1 to C 6 alkyl and R 2 is H.
Claim 21
Dependent Claim
24 words
A compound according to claim 16 wherein R 2 and R 3 are C 1 to C 6 alkyl and R 2 is H.
Claim 22
Dependent Claim
14 words
A compound according to claim 14 wherein n is 0 and M is 3.
Claim 23
Dependent Claim
44 words
A method of inhibiting lipoxygenase activity in a human or lower animal host in need of such treatment, comprising administering to the human or lower animal host a compound according to claim 14 in an amount effective to inhibit lipoxygenase activity in the host.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-25 | 1990-02-24 | 1990-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-25 | 1994-02-24 | 1994-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-25 | 1998-02-24 | 1998-08-26 | $7700.00 | Window Closed / Lapsed |