US4109013A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted propanol-(2) derivatives of hydroxamic acids and the use thereof as hypolipemic drugs
Assignee: Astellas Deutschland GmbH
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Filing: 1977-11-09
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Granted: 1978-08-22
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Expires: 1997-11-09
Abstract
Abstract New 1,3-disubstituted propanol-(2) derivatives and their nicotinic acid esters of the general formula ##STR1## and their therapeutically acceptable salts, processes for preparing the same and the use thereof and pharmaceutical preparations containing the same for the treatment of hyperlipemia.
Inventors
- 👤 Helmut Grill
- 👤 Rainer Hans Zschocke
- 👤 Josef Wagner
- 👤 Gernot Hofrichter
- 👤 P. Stefan Janiak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 01:02
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/24; C07D213/28; C07D213/30; C07C; C07C323/00; C07D213/60; C07D213/78; C07D213/79; C07D213/80; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/18; C07D317/22
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
51 words
A 1,3-disubstituted propanol-(2) derivative of the general formula ##STR33## or its therapeutically acceptable salt, where X and Y stand for --O--; R 1 = --Cl, or --C(CH 3 ) 3 ; R 2 = --h; a = a valence bond, a vinylene group, or an ethylene group; R 3 = --conhoh.
Claim 2
Dependent Claim
51 words
A 1,3-disubstituted propanol-(2) derivative of the general formula ##STR33## or its therapeutically acceptable salt, where X and Y stand for --O--; R 1 = --Cl, or --C(CH 3 ) 3 ; R 2 = --h; a = a valence bond, a vinylene group, or an ethylene group; R 3 = --conhoh.
Claim 3
Dependent Claim
35 words
the compound of claim 1, where X and Y stand for --O--; R 1 = --cl, or --C(CH 3 ) 3 ; R 2 = --h; a = a valence bond; R 3 = --conhoh.
Claim 4
Dependent Claim
1 words
3-(4'-(n-hydroxycarbamoyl)-phenoxy)-1-(4'-t.-butylphenoxy)-propanol-(2).
Claim 5
Dependent Claim
1 words
3-(4'-(n-hydroxycarbamoyl)-phenoxy)-1-(4'-t.-butylphenoxy)-propanol-(2).
Claim 6
Dependent Claim
29 words
A medicinal composition, for the treatment of hyperlipemia containing an effective amount of a compound according to claim 1 as the active substance together with a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
22 words
Medicinal composition according to claim 4, characterized in that the single dose of the particular medicinal form contains 10-500 mg active substance.
Claim 8
Dependent Claim
13 words
A medicinal composition according to claim 5, wherein the active substance is 3-(4'-(N-hydroxycarbamoyl)-phenoxy)-1-(4'-t.-butylphenoxy)-propanol-(2).
Claim 9
Dependent Claim
27 words
A method for treating hyperlipemia which comprises administering to a subject in need of such treatment, a therapeutically effective dose of a compound according to claim 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-21 | 1982-02-20 | 1982-08-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-21 | 1986-02-20 | 1986-08-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-21 | 1990-02-20 | 1990-08-22 | $7700.00 | Window Closed / Lapsed |