Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis

Claim 1

A compound of Formula I: ##STR149## wherein the compound is selected from the following group: ______________________________________ Com- pound R.sub.1 R.sub.2 R.sub.3 R.sub.4 R ______________________________________ 172 CH.sub.3 OC(CH.sub.3).sub.3 4-OH H H 216 Me OEt 4-OH 5-CH.sub.2 OH H 217 Me OEt 5-OAc H H 218 Me OEt 4-OH 5-CH.sub.2 OEt H 226 Me OEt ##STR150## H H 227 Me ##STR151## 4-OAc H H 230 Me OMe ##STR152## 5-CH.sub.2 CHCH.sub.2 H 231 Me OEt ##STR153## 5-Pr H 241 Me OEt 5-OH 4-CH.sub.2 CHCH.sub.2 H 242 Me OEt 4-OH 5-CH.sub.2 CHCH.sub.2 H 245 Ph OEt 6-OH H H 246 Me OEt 5-NHAc H H 250 Pr OEt 4-OH H H 252 Me OEt 4-OH 5-Pr H 253 Ph OEt 4-OH H H 254 Ph OEt 4-OH ##STR154## H 259 Me ##STR155## 4-OH H H 261 CH.sub.3 OH 4-OH 5-Pr H 263 Me ##STR156## 4-OH H H 288 CH.sub.3 OEt ##STR157## H H 366 CH.sub.3 OEt 4-OH 5-CH.sub.2 CH.sub.2 CH.sub.3 7-F 367 CH.sub.3 OEt 4-OH 5-CH.sub.2 CH.sub.2 CH.sub.3 7-Cl ______________________________________