US3723619A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Diuretic and saluretic compositions and method with 3-tertiary amino propionyl-benzofuran-2-carboxylic acids
Assignee: Novartis Corp
•
Filing: 1970-11-18
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Granted: 1973-03-27
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Expires: 1990-11-18
Abstract
Abstract 5-(2-Di(lower)alkylaminomethyl-(lower)alkanoyl)-benzofuran-2carboxylic acids and their pharmaceutically acceptable salts with acids and bases are prepared by Mannich condensation of 5-loweralkanoyl-substituted benzofuran-2-carboxylic acids with paraformaldehyde and secondary amines. A typical embodiment is 5-(2dimethylaminomethyl-butyryl)-6-methyl-benzofuran-2-carboxylic acid hydrochloride. A method of producing a diuretic and a saluretic effect comprising administration of said compounds to warm-blooded animals as well as pharmaceutical compositions containing said compounds are provided.
Inventors
- 👤 J Zergenyi
- 👤 E Habicht
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 13:41
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/78; C07D307/82; C07D307/84; C07D307/85
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
12 words
A method according to claim 1 wherein said compound is 5-(2-dimethylaminomethyl-butyryl)-6-methyl-benzofuran-2-carboxylic acid.
Claim 2
Dependent Claim
12 words
A method according to claim 1 wherein said compound is 5-(2-piperidinomethyl-butyryl)-6-methyl-benzofuran-2-carboxylic acid.
Claim 3
Dependent Claim
12 words
A method according to claim 1 wherein said compound is 5-(2-morpholinomethyl-butyryl)-6-methyl-benzofuran-2-carboxylic acid.
Claim 4
Dependent Claim
12 words
A method according to claim 1 wherein said compound is 5-(2-dimethylaminomethyl-propionyl)-6-methyl-benzofuran-2-carboxylic acid.
Claim 5
Dependent Claim
40 words
A pharmaceutical composition comprising a combination in dosage unit fOrm of a pharmaceutical carrier and an amount sufficient to produce a diuretic and a saluretic effect upon administration of said dosage unit form of a compound of the Formula I
Claim 6
Dependent Claim
12 words
A composition according to claim 6 wherein said compound is 5-(2-dimethylaminomethyl-butyryl)-6-methyl-benzofuran-2-carboxylic acid.
Claim 7
Dependent Claim
12 words
A composition according to claim 6 wherein said compound is 5-(2-piperidinomethyl-butyryl)-6-methyl-benzofuran-2-carboxylic acid.
Claim 8
Dependent Claim
12 words
A composition according to claim 6 wherein said compound is 5-(2-morpholinomethyl-butyryl)-6-methyl-benzofuran-2-carboxylic acid.
Claim 9
Dependent Claim
12 words
A composition according to claim 6 wherein said compound is 5-(2-dimethylaminomethyl-propionyl)-6-methyl-benzofuran-2-carboxylic acid.
References Cited (Backward Citations)
US3551458A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1976-03-26 | 1976-09-25 | 1977-03-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1980-03-26 | 1980-09-25 | 1981-03-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1984-03-26 | 1984-09-25 | 1985-03-27 | $7700.00 | Window Closed / Lapsed |