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US4656161A
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Increasing the enteral absorbability of heparin or heparinoids
Assignee: BASF SE
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Filing: 1984-08-27
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Granted: 1987-04-07
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Expires: 2004-08-27
Abstract
Abstract An enterally absorbable heparin or heparinoid preparation contains a non-ionic surfactant.
Inventors
- 👤 Dieter Herr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 14:03
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/14; A61K47/26; A61K9/00; A61K9/48; A61K9/4841; A61K9/4858; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
85 words
A method of preventing thrombosis and for inhibiting blood coagulation in a patient which comprises: orally administering to the patient an effective amount of a composition which consists essentially of heparin having a molecular weight of from 1,200 to about 30,000 as the active agent, at least about 0.2 part by weight of a physiologically tolerated non-ionic surfactant per part by weight of heparin and a pharmaceutically acceptable carrier and/or diluent said surfactant prepared by reacting ethylene oxide with a fatty alcohol or an alkylphenol.
Claim 2
Independent Claim
85 words
A method of preventing thrombosis and for inhibiting blood coagulation in a patient which comprises: orally administering to the patient an effective amount of a composition which consists essentially of heparin having a molecular weight of from 1,200 to about 30,000 as the active agent, at least about 0.2 part by weight of a physiologically tolerated non-ionic surfactant per part by weight of heparin and a pharmaceutically acceptable carrier and/or diluent said surfactant prepared by reacting ethylene oxide with a fatty alcohol or an alkylphenol.
Claim 3
Dependent Claim
65 words
The method of claim 1, wherein the surfactant has the formula R--[(CH.sub.2).sub.n --O].sub.m --H I where R is alkoxy, alkylaryloxy, acylamino or acyloxy, each of 4 to 22 carbon atoms, or an acylated sorbitan or glycerol radical where the acyl radical is of 4 to 22 carbon atoms, n is an integer from 2 to 6 and m is an integer from 1 to 200.
Claim 4
Dependent Claim
34 words
The method of claim 2, wherein R is a hydrocarbon radical of 7 to 18 carbons containing 1 or more double bonds, n is 2 or 3 and m is from 10 to 100.
Claim 5
Dependent Claim
23 words
The method of claim 1, wherein the daily amount of the composition administered to the patient is from about 50 to 5000 IU/kg.
References Cited (Backward Citations)
GB891554A
Cited
DE1492011A1
Cited
US3510561A
Cited
US3482014A
Cited
US3577534A
Cited
GB1381426A
Cited
US4021544A
Cited
US4021545A
Cited
US4066829A
Cited
GB1563161A
Cited
US4239754A
Cited
DE2807248A1
Cited
US4156719A
Cited
EP0036145A1
Cited
FR2492259A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-06 | 1990-10-06 | 1991-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-06 | 1994-10-06 | 1995-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-06 | 1998-10-06 | 1999-04-07 | $7700.00 | Window Closed / Lapsed |