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Patent US2496839A successfully refreshed from Google Patents.
US4156719A
Expired / Lapsed
US
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Compositions for rectal use
Assignee: Astellas Pharma Inc
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Filing: 1978-02-23
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Granted: 1979-05-29
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Expires: 1998-02-23
Abstract
Abstract A micellar solution composition for rectal use comprising (a) a water-soluble drug which is poorly absorbable on oral administration (b) a middle-higher fatty acid and/or the mono- or di-glyceride thereof, (c) a bile acid and/or a nonionic surface active agent, and (d) water; and a powder composition for rectal use prepared by drying the aforesaid micellar solution composition.
Inventors
- 👤 Hitoshi Sezaki
- 👤 Shozo Muranishi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:33
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/02; A61K9/10; A61K9/107; A61K9/1075
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
68 words
A micellar solution composition for rectal use comprising (a) an effective amount of a water-soluble drug which is poorly absorbable on oral administration, (b) 5 to 100 millimoles per liter of at least one of a middle-higher fatty acid and the mono- or di-glyceride thereof, (c) 0.3 to 60g per liter of at least one of a bile acid and a nonionic surface active agent, and (d) water.
Claim 2
Dependent Claim
68 words
A micellar solution composition for rectal use comprising (a) an effective amount of a water-soluble drug which is poorly absorbable on oral administration, (b) 5 to 100 millimoles per liter of at least one of a middle-higher fatty acid and the mono- or di-glyceride thereof, (c) 0.3 to 60g per liter of at least one of a bile acid and a nonionic surface active agent, and (d) water.
Claim 3
Dependent Claim
73 words
A powder composition for rectal use prepared by drying a micellar solution comprising (a) an effective amount of a water-soluble drug which is poorly absorbable at oral administration, (b) 5 to 100 millimoles per liter of at least one of a middle-higher fatty acid and the mono- or di-glyceride thereof, (c) 0.3 to 60g per liter of at least one of a bile acid and a nonionic surface active agent, and (d) water.
Claim 4
Dependent Claim
73 words
A powder composition for rectal use prepared by drying a micellar solution comprising (a) an effective amount of a water-soluble drug which is poorly absorbable at oral administration, (b) 5 to 100 millimoles per liter of at least one of a middle-higher fatty acid and the mono- or di-glyceride thereof, (c) 0.3 to 60g per liter of at least one of a bile acid and a nonionic surface active agent, and (d) water.
Claim 5
Dependent Claim
38 words
The micellar solution composition for rectal use as claimed in claim 1 wherein said water-soluble drug which is poorly absorbable on oral use is a member selected from the group consisting of streptomycin, Gentamycin, cefaxolin, bleomycin and heparin.
Claim 6
Dependent Claim
37 words
The powder composition for rectal use as claimed in claim 2 wherein said water-soluble drug which is poorly absorbable on oral administration is a member selected from the group consisting of streptomycin, Gentamycin, cefazolin, bleomycin, and heparin.
Claim 7
Dependent Claim
39 words
The micellar solution composition for rectal use as claimed in claim 1 wherein said middle-higher fatty acid and the mono- or di-glyceride thereof is a member selected from the group consisting of oleic acid, linoleic acid, 1-monoolein, or lysolecithin.
Claim 8
Dependent Claim
39 words
The powder composition for rectal use as claimed in claim 2 wherein said one middle-higher fatty acid and the mono- or di-glyceride thereof is a member selected from the group consisting of oleic acid, linoleic acid, 1-monoolein, and /ysolecithin.
Claim 9
Dependent Claim
22 words
The micellar solution composition for rectal use as claimed in claim 1 wherein said bile acid is sodium glycocholate or sodium taurocholate.
Claim 10
Dependent Claim
21 words
The powder composition for rectal use as claimed in claim 2 wherein said bile acid is sodium glycocholate or sodium taurocholate.
Claim 11
Dependent Claim
32 words
The micellar solution composition for rectal use as claimed in claim 1 wherein said nonionic surface active agent is a polyoxyethylene sorbitan fatty acid ester or a polyoxyethylene hardened castor oil derivative.
Claim 12
Dependent Claim
31 words
The powder composition for rectal use as claimed in claim 2 wherein said nonionic surface active agent is a polyoxyethylene sorbitan fatty acid ester or a polyoxyethylene hardened castor oil derivative.
Claim 13
Dependent Claim
14 words
The powder composition as claimed in claim 2, further including a pharmaceutically acceptable carrier.
Claim 14
Dependent Claim
26 words
A method of administering a water-soluble drug which is poorly absorbable on oral administration comprising rectally administering an effective amount of the composition of claim 1.
Claim 15
Dependent Claim
26 words
A method of administering a water-soluble drug which is poorly absorbable on oral administration comprising rectally administering an effective amount of the composition of claim 2.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-28 | 1982-11-27 | 1983-05-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-28 | 1986-11-27 | 1987-05-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-28 | 1990-11-27 | 1991-05-29 | $7700.00 | Window Closed / Lapsed |