USRE28819E
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dialkylated glycol compositions and medicament preparations containing same
Assignee: Syntex USA LLC
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Filing: 1975-04-16
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Granted: 1976-05-18
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Expires: 1995-04-16
Abstract
Abstract A pharmaceutical preparation having a minor amount of a medicament, a major amount of a dialkylated mono- or poly-alkylene glycol vehicle therefor, and a minor amount of one or more antioxidants for the dialkylated glycol vehicle.
Inventors
- 👤 Geoffrey F. Thompson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 13:39
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/557; A61K47/00; A61K47/06; A61K47/08
Claims Analysis
Total Claims: 30
Claim 1
Independent Claim
137 words
A composition .Iadd.containing a minimum amount of water, up to 5%, and .Iaddend.comprising a major amount of dialkylated glycol represented by the formula: ##EQU2## where R and R 1 are independently lower alkyl having 1 to 6 carbon atoms, R 2 is hydrogen or a lower alkyl having 1 to 6 carbon atoms m is integer from 1 to 6, and n is an integer from 1 to a very large number such that the molecular weight of said dialkylated glycol is up to about 20,000, and a minor amount of at least one antioxidant for said dialkylated glycol material, said composition being substantially devoid of peroxides and other oxidation products in quantities which interfere with the carrier or stabilizing properties of said composition .Iadd., said composition being suitable for use as a vehicle for medicament preparations.Iaddend..
Claim 2
Dependent Claim
137 words
A composition .Iadd.containing a minimum amount of water, up to 5%, and .Iaddend.comprising a major amount of dialkylated glycol represented by the formula: ##EQU2## where R and R 1 are independently lower alkyl having 1 to 6 carbon atoms, R 2 is hydrogen or a lower alkyl having 1 to 6 carbon atoms m is integer from 1 to 6, and n is an integer from 1 to a very large number such that the molecular weight of said dialkylated glycol is up to about 20,000, and a minor amount of at least one antioxidant for said dialkylated glycol material, said composition being substantially devoid of peroxides and other oxidation products in quantities which interfere with the carrier or stabilizing properties of said composition .Iadd., said composition being suitable for use as a vehicle for medicament preparations.Iaddend..
Claim 3
Dependent Claim
17 words
The composition of claim 1 wherein said dialkylated glycol is a dimethyl ether of a polyethylene glycol.
Claim 4
Dependent Claim
19 words
The composition of claim 2 wherein said dialkylated glycol has a molecular weight from about 350 to about 750.
Claim 5
Dependent Claim
11 words
The composition of claim 1 wherein said dialkylated glycol is 1,2-dimethoxyethane.
Claim 6
Dependent Claim
16 words
The composition of claim 1 wherein said dialkylated glycol is a dimethyl ether of triethylene glycol.
Claim 7
Dependent Claim
12 words
The composition of claim 1 wherein R and R 1 are methyl.
Claim 8
Dependent Claim
17 words
The composition of claim 1 wherein R and R 1 are methyl, and R 2 is hydrogen.
Claim 9
Dependent Claim
26 words
The composition of claim 1 wherein said antioxidant is selected from the group consisting of propyl gallate, vitamin E, butylated hydroxyanisole, butylated hydroxytoluene, and mixtures thereof.
Claim 10
Dependent Claim
17 words
The composition of claim 1 wherein said composition includes about 0.01% to about 1.0% of said antioxidant.
Claim 11
Dependent Claim
19 words
The composition of claim 1 wherein said composition includes about 0.025% butylated hydroxy anisole and about 0.025% butylated hydroxytoluene.
Claim 12
Dependent Claim
39 words
The composition of claim 1 further including a therapeutically effective amount of active medicament material, or a pharmaceutically acceptable salt thereof. .[.12. The composition of claim 1 wherein said composition contains less than 5% water..]. .[.13. The composition of
Claim 13
Dependent Claim
12 words
claim 11 wherein said composition contains less than 5% water..]. 14. The
Claim 14
Dependent Claim
45 words
composition of claim 11 wherein said medicament is an antibiotic. 15. The composition of claim 11 wherein said medicament is relatively chemically unstable and the chemical activity of said medicament in said composition is stabilized by said dialkylated glycol over an extended period of time.
Claim 15
Dependent Claim
10 words
The composition of claim 11 wherein said medicament is an
Claim 16
Dependent Claim
13 words
anti-inflammatory steroid. 17. The composition of claim 11 wherein said medicament is 6α,9α-difluoro-11β-hydroxy-16α,17α-isopropyli
Claim 17
Dependent Claim
12 words
denedioxypregna-1,4-diene-3,20-dione. 18. The composition of claim 11 wherein said medicament is 9α,11β,21-trichloro-6α-fluoro-16α,17α-isoprop
Claim 18
Dependent Claim
16 words
ylidenedioxypregna-1,4-diene-3,20-dione. 19. The composition of claim 11 wherein said medicament is a naturally occurring or synthetic
Claim 19
Dependent Claim
42 words
prostaglandin. 20. The composition of claim 11 whererin .[.said composition contains less than 5% water, and.]. said medicament is PGE 2 , said dialkylated glycol serving to stabilize the chemical activity of said PGE 2 in said composition over extended periods of
Claim 20
Dependent Claim
44 words
time. 21. The composition of claim 11 wherein .[.said composition contains less than 5% water, and.]. said medicament is acetyl salicylic acid, said dialkylated glycol serving to stabilize the chemical activity of said acetyl salicylic acid in said composition over extended periods of time.
Claim 21
Dependent Claim
36 words
. The composition of claim 11 wherein .[.said composition contains less than 5% water, and.]. said medicament is N,N-bis(2-hydroxyethyl)-oleamide, said dialkylated glycol serving to stabilize the chemical activity of said N,N-bis-(2-hydroxyethyl)-oleamide in said composition over extended
Claim 22
Dependent Claim
130 words
periods of time. 23. A composition .Iadd.containing a minimum amount of water, up to about 5%, and .Iaddend.comprising a major amount of a dialkylated glycol represented by the formula: ##EQU3## where R and R 1 are independently lower alkyl having 1 to 6 carbon atoms, R 2 is hydrogen or a lower alkyl having 1 to 6 carbon atoms, m is an integer from 1 to 6, and n is an integer from 1 to a very large number such that the molecular weight of said dialkylated glycol is up to about 20,000, and a therapeutically effective amount of an active medicament or a pharmaceutically acceptable salt thereof, said composition being substantially devoid of peroxides and other oxidation products in quantities which interfere with the carrier or stabilizing properties of
Claim 23
Dependent Claim
130 words
periods of time. 23. A composition .Iadd.containing a minimum amount of water, up to about 5%, and .Iaddend.comprising a major amount of a dialkylated glycol represented by the formula: ##EQU3## where R and R 1 are independently lower alkyl having 1 to 6 carbon atoms, R 2 is hydrogen or a lower alkyl having 1 to 6 carbon atoms, m is an integer from 1 to 6, and n is an integer from 1 to a very large number such that the molecular weight of said dialkylated glycol is up to about 20,000, and a therapeutically effective amount of an active medicament or a pharmaceutically acceptable salt thereof, said composition being substantially devoid of peroxides and other oxidation products in quantities which interfere with the carrier or stabilizing properties of
Claim 24
Dependent Claim
32 words
said composition. 24. The composition of claim 23 wherein said dialkylated glycol is selected from the group consisting of the dimethyl ether of polyethylene glycol, the dimethyl ether of triethylene glycol, glyme,
Claim 25
Dependent Claim
11 words
diglyme, triglyme, and tetraglyme. 25. The composition of claim 23 wherein
Claim 26
Dependent Claim
21 words
said medicament is an anti-inflammatory steroid. 26. The composition of claim 23 wherein said medicament is a naturally occurring or synthetic
Claim 27
Dependent Claim
60 words
prostaglandin. 27. The composition of claim 23 wherein .[.said composition contains less than 5% water, and.]. said medicament is selected from the group consisting of acetyl salicylic acid, PGE 2 , and N,N-bis(2-hydroxyethyl)-oleamide, said dialkylated glycol serving to stabilize the chemical activity of said medicament in said composition over extended periods of time. .[.28. The composition of claim 23 wherein
Claim 28
Dependent Claim
11 words
said composition contains less than 5% water..]. 29. The composition of
Claim 29
Dependent Claim
11 words
said composition contains less than 5% water..]. 29. The composition of
Claim 30
Dependent Claim
43 words
claim 23 wherein said medicament is an antibiotic. 30. The composition of claim 23 wherein said medicament is relatively chemically unstable and the chemical activity of said medicament in said composition is stabilized by said dialkylated glycol over an extended period of time.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-18 | 1979-11-17 | 1980-05-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-18 | 1983-11-17 | 1984-05-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-18 | 1987-11-17 | 1988-05-18 | $7700.00 | Window Closed / Lapsed |