US4656161A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Increasing the enteral absorbability of heparin or heparinoids
Assignee: BASF SE
•
Filing: 1984-08-27
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Granted: 1987-04-07
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Expires: 2004-08-27
Abstract
Abstract An enterally absorbable heparin or heparinoid preparation contains a non-ionic surfactant.
Inventors
- 👤 Dieter Herr
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 10:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/14; A61K47/26; A61K9/00; A61K9/48; A61K9/4841; A61K9/4858; A61P; A61P7/00; A61P7/02
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
85 words
A method of preventing thrombosis and for inhibiting blood coagulation in a patient which comprises: orally administering to the patient an effective amount of a composition which consists essentially of heparin having a molecular weight of from 1,200 to about 30,000 as the active agent, at least about 0.2 part by weight of a physiologically tolerated non-ionic surfactant per part by weight of heparin and a pharmaceutically acceptable carrier and/or diluent said surfactant prepared by reacting ethylene oxide with a fatty alcohol or an alkylphenol.
Claim 2
Independent Claim
85 words
A method of preventing thrombosis and for inhibiting blood coagulation in a patient which comprises: orally administering to the patient an effective amount of a composition which consists essentially of heparin having a molecular weight of from 1,200 to about 30,000 as the active agent, at least about 0.2 part by weight of a physiologically tolerated non-ionic surfactant per part by weight of heparin and a pharmaceutically acceptable carrier and/or diluent said surfactant prepared by reacting ethylene oxide with a fatty alcohol or an alkylphenol.
Claim 3
Dependent Claim
65 words
The method of claim 1, wherein the surfactant has the formula R--[(CH.sub.2).sub.n --O].sub.m --H I where R is alkoxy, alkylaryloxy, acylamino or acyloxy, each of 4 to 22 carbon atoms, or an acylated sorbitan or glycerol radical where the acyl radical is of 4 to 22 carbon atoms, n is an integer from 2 to 6 and m is an integer from 1 to 200.
Claim 4
Dependent Claim
34 words
The method of claim 2, wherein R is a hydrocarbon radical of 7 to 18 carbons containing 1 or more double bonds, n is 2 or 3 and m is from 10 to 100.
Claim 5
Dependent Claim
23 words
The method of claim 1, wherein the daily amount of the composition administered to the patient is from about 50 to 5000 IU/kg.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-06 | 1990-10-06 | 1991-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-06 | 1994-10-06 | 1995-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-06 | 1998-10-06 | 1999-04-07 | $7700.00 | Window Closed / Lapsed |