Patent US4643718A successfully refreshed from Google Patents.
US4643718A
Expired / Lapsed
US
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Therapeutic apheresis
Assignee: Applied Immune Sciences Inc
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Filing: 1985-07-23
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Granted: 1987-02-17
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Expires: 2005-07-23
Abstract
Abstract Disclosure is made of a means and method for removing immunologically reactive compounds from the blood of living mammals. The method of the invention comprises reacting the compound with an immunological homolog of the compound, bound to the surface of a lipid vesicle and thereafter separating the resulting complex from the blood plasma of the mammal.
Inventors
- 👤 James F. Marten
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:47
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3687; A61M2202/00; A61M2202/0014; A61M2202/04; A61M2202/0413; A61M2202/0445; A61M2202/0447; A61M2202/0456
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
134 words
A method of removing an immunologically reactive compound from the blood of a living mammal, which comprises; removing the whole blood from a living mammal in an extra corporeal, closed circuit; separating a portion of the blood plasma from the whole blood within the extra corporeal circuit, by passage of the portion through an ultrafilter, said ultrafilter permitting the passage of plasma with dissolved immunologically reactive compounds, but not permitting the passage of solids within said blood; reacting the separated immunologically reactive compound with its homolog bound to the surface of a lipid vesicle; separating the resulting lipid vesicle complex from the plasma; passing the blood plasma minus lipid vesicle bound immunologically reactive compound to the whole blood in the extra corporeal stream; and passing the whole blood back to the mammal's circulatory system.
Claim 2
Independent Claim
134 words
A method of removing an immunologically reactive compound from the blood of a living mammal, which comprises; removing the whole blood from a living mammal in an extra corporeal, closed circuit; separating a portion of the blood plasma from the whole blood within the extra corporeal circuit, by passage of the portion through an ultrafilter, said ultrafilter permitting the passage of plasma with dissolved immunologically reactive compounds, but not permitting the passage of solids within said blood; reacting the separated immunologically reactive compound with its homolog bound to the surface of a lipid vesicle; separating the resulting lipid vesicle complex from the plasma; passing the blood plasma minus lipid vesicle bound immunologically reactive compound to the whole blood in the extra corporeal stream; and passing the whole blood back to the mammal's circulatory system.
Claim 3
Dependent Claim
18 words
The method of claim 1 wherein the reactive compound is an antigen and the homolog in an antibody.
Claim 4
Dependent Claim
12 words
The method of claim 2 wherein the antibody is a monoclonal antibody.
Claim 5
Dependent Claim
18 words
The method of claim 1 wherein the reactive compound is an antibody and the homolog is an antigen.
Claim 6
Dependent Claim
13 words
The method of claim 1 wherein the lipid vesicles encapsulate a tracer compound.
Claim 7
Dependent Claim
12 words
The method of claim 1 wherein the ultrafilter comprises a hollow fiber.
Claim 8
Dependent Claim
29 words
The method of claim 1 wherein there are a plurality of different reactive compounds to be removed and a plurality of different homologs are employed, bound to lipid vesicles.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-02-16 | 1990-08-18 | 1991-02-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-02-16 | 1994-08-18 | 1995-02-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-02-16 | 1998-08-18 | 1999-02-17 | $7700.00 | Window Closed / Lapsed |