Patent US4618489A successfully refreshed from Google Patents.
US4618489A
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Dental compositions and method of use therefor
Assignee: RESEARCH FOUNDATION A NY CORP
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Filing: 1983-09-02
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Granted: 1986-10-21
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Expires: 2003-09-02
Abstract
Abstract Dental compositions containing bicarbonate anion in combination with a monovalent anion such as fluoride, chloride or thiocyanate and methods of using them in anti-caries therapy are disclosed herein.
Inventors
- 👤 Jerry J. Pollock
- 👤 Thomas F. McNamara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 13:10
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/20; A61K8/21; A61K8/23
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
121 words
A method of inhibiting or reducing Streptococcus mutans colonization of carious lesions of tooth surfaces infected with cariogenic strains of S. mutans in substantially normal physiological concentrations in submandibular, parotide and mixed human salivas containing concentrations of bicarbonate ion of from about 1 to about 60 mM., chloride ion from about 10 to about 50 mM., and thiocyanate ion from about 0.5 to 4.5 mM., said concentrations being ineffective to kill bacteria, which comprises: treating between one and three times a day the sites of caries lesions on said teeth with about 0.03M sodium bicarbonate by weight used in combination with about 0.03M. sodium chloride, and 0.03M. sodium thiocyanate at least until the significant reduction of S. mutans can be noted.
Claim 2
Independent Claim
121 words
A method of inhibiting or reducing Streptococcus mutans colonization of carious lesions of tooth surfaces infected with cariogenic strains of S. mutans in substantially normal physiological concentrations in submandibular, parotide and mixed human salivas containing concentrations of bicarbonate ion of from about 1 to about 60 mM., chloride ion from about 10 to about 50 mM., and thiocyanate ion from about 0.5 to 4.5 mM., said concentrations being ineffective to kill bacteria, which comprises: treating between one and three times a day the sites of caries lesions on said teeth with about 0.03M sodium bicarbonate by weight used in combination with about 0.03M. sodium chloride, and 0.03M. sodium thiocyanate at least until the significant reduction of S. mutans can be noted.
Claim 3
Dependent Claim
49 words
A fluoride free dentrifice consisting essentially of between about 0.1% and 1.75% by weight bicarbonate ion, between about 0.15 and 0.7% by weight of chloride ion and between about 0.2 and 1% by weight of thiocyanate ion in combination with a pharmaceutically acceptable cation as the pharmacological active ingredients.
Claim 4
Dependent Claim
49 words
A fluoride free dentrifice consisting essentially of between about 0.1% and 1.75% by weight bicarbonate ion, between about 0.15 and 0.7% by weight of chloride ion and between about 0.2 and 1% by weight of thiocyanate ion in combination with a pharmaceutically acceptable cation as the pharmacological active ingredients.
Claim 5
Dependent Claim
14 words
A fluoride free dentrifice in accordance with claim 2 formulated into a tooth paste.
Claim 6
Dependent Claim
57 words
A dentrifice consisting essentially of between about 0.1 and 0.5% by weight of sodium fluoride, between about 0.1% and 1.75% by weight bicarbonate ion, between about 0.15 and 0.7% by weight of chloride ion and between about 0.2 and 1% by weight of thiocyanate ion in combination with a pharmaceutically acceptable cation as the pharmacological active ingredients.
Claim 7
Dependent Claim
57 words
A dentrifice consisting essentially of between about 0.1 and 0.5% by weight of sodium fluoride, between about 0.1% and 1.75% by weight bicarbonate ion, between about 0.15 and 0.7% by weight of chloride ion and between about 0.2 and 1% by weight of thiocyanate ion in combination with a pharmaceutically acceptable cation as the pharmacological active ingredients.
Claim 8
Dependent Claim
12 words
A dentrifice in accordance with claim 4 formulated in a tooth paste.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-10-20 | 1990-04-21 | 1990-10-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-10-20 | 1994-04-21 | 1994-10-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-10-20 | 1998-04-21 | 1998-10-21 | $7700.00 | Window Closed / Lapsed |