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US4269822A
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Antiseptic dentifrice
Assignee: Laclede Professional Products Inc
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Filing: 1980-08-29
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Granted: 1981-05-26
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Expires: 2000-08-29
Abstract
Abstract An antiseptic dentifrice is provided which contains an enzyme system comprising an oxidizable amino acid substrate and an oxidoreductase enzyme specific to such substrate for producing hydrogen peroxide and ammonia upon oral application of the dentifrice. In an illustrative enzyme system for this purpose, the substrate is glycine and the oxidoreductase enzyme specific to this substrate is glycine oxidase.
Inventors
- 👤 Michael A. Pellico
- 👤 Robert E. Montgomery
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 18:08
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/64; A61K8/66; A61K8/40; A61K8/44; A61Q; A61Q11/00
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
100 words
An antiseptic dentifrice containing from about 0.01 to about 0.5 wt.% of an oxidizable amino acid substrate and from about 50 to about 1,000 International Units of an oxidoreductase enzyme specific to said substrate for producing ammonia and hydrogen peroxide upon oral applicaton of said dentifrice, said dentifrice being stabilized against the production of ammonia and hydrogen peroxide prior to the oral application thereof by incorporating into the dentifrice a non-aqueous fluid carrier in an amount from about 30 to about 60 wt.% and limiting any water present in the dentifrice to an amount not more than about 10 wt.%.
Claim 2
Dependent Claim
100 words
An antiseptic dentifrice containing from about 0.01 to about 0.5 wt.% of an oxidizable amino acid substrate and from about 50 to about 1,000 International Units of an oxidoreductase enzyme specific to said substrate for producing ammonia and hydrogen peroxide upon oral applicaton of said dentifrice, said dentifrice being stabilized against the production of ammonia and hydrogen peroxide prior to the oral application thereof by incorporating into the dentifrice a non-aqueous fluid carrier in an amount from about 30 to about 60 wt.% and limiting any water present in the dentifrice to an amount not more than about 10 wt.%.
Claim 3
Dependent Claim
35 words
The dentifrice of claim 1 wherein the substrate is a D-amino acid selected from the group consisting of D isomers of proline, methionine, isoleucine, alanine, valine and phenylalanine and the enzyme is D-amino acid oxidase.
Claim 4
Dependent Claim
41 words
The dentifrice of claim 1 wherein the substrate is a L-amino acid selected from the group consisting of L isomers of isoleucine, 2-aminobutanoic acid, citrulline, histidine, leucine, methionine, norleucine, norvaline, phenylalanine, tryptophane, and tyrosine and the enzyme is L-amino acid oxidase.
Claim 5
Dependent Claim
16 words
The dentifrice of claim 1 wherein the substrate is glycine and the enzyme is glycine oxidase.
Claim 6
Dependent Claim
12 words
The dentifrice of claim 1 wherein the non-aqueous fluid carrier is glycerin.
Claim 7
Dependent Claim
13 words
The dentifrice of claim 1 wherein the non-aqueous fluid carrier is propylene glycol.
Claim 8
Dependent Claim
20 words
The dentifrice of claim 1 which includes a protein surfactant in an amount from about 0.5 to about 5.0 wt.%.
Claim 9
Dependent Claim
22 words
The dentifrice of claim 1 which includes a dioctyl sodium sulfosuccinate surfactant in an amount from about 0.5 to about 5.0 wt.%.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-05-25 | 1984-11-24 | 1985-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-05-25 | 1988-11-24 | 1989-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-05-25 | 1992-11-24 | 1993-05-26 | $7700.00 | Window Closed / Lapsed |