US4178362A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enzymatic dentifrices
Assignee: Telec SA
•
Filing: 1978-11-09
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Granted: 1979-12-11
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Expires: 1998-11-09
Abstract
Abstract A novel enzymatic dentifrice comprises as its essential active ingredient an amount of glucose oxidane enzyme which forms hydrogen peroxide by oxidative decomposition of a glucose substrate provided by glucose present in saliva and tooth plaque so as to cause a substantial shift toward neutral values in the pH at the surface of teeth, when said pH is below the neutral range.
Inventors
- 👤 Hendrik Hoogendoorn
- 👤 Rutger Matthijsen
- 👤 Huibert C. T. Moelker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:48
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/22; A61K8/30; A61K8/64; A61K8/66
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
114 words
An enzyme dentifrice chewing gum or tablet consisting of about 0.5 to about 20 units per gram/milliliter of glucose oxidase enzyme which forms hydrogen peroxide by oxidative decomposition of a glucose substrate provided by glucose present in sufficient amount in saliva and tooth plaque, said hydrogen peroxide being formed in a continuous concentration no greater than 10 -4 %, said unit being the quantity of the enzyme which will oxidize 1 micromol of substrate per minute at 30° C. and pH 6, effective when applied to a dental surface exhibiting a pH below the neutral range, to restore the pH at said dental surface to an approximately neutral range, and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
114 words
An enzyme dentifrice chewing gum or tablet consisting of about 0.5 to about 20 units per gram/milliliter of glucose oxidase enzyme which forms hydrogen peroxide by oxidative decomposition of a glucose substrate provided by glucose present in sufficient amount in saliva and tooth plaque, said hydrogen peroxide being formed in a continuous concentration no greater than 10 -4 %, said unit being the quantity of the enzyme which will oxidize 1 micromol of substrate per minute at 30° C. and pH 6, effective when applied to a dental surface exhibiting a pH below the neutral range, to restore the pH at said dental surface to an approximately neutral range, and a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
67 words
The enzyme dentifrice of claim 1 wherein the concentration of hydrogen peroxide is insufficient to inhibit the saliva enzyme lactoperoxidase required for oxygen transfer from peroxide to oral bacteria cells, and thereby to accomplish bacterial inactivation by hydrogen peroxide, which, if otherwise present in high or moderate concentrations, inhibits the lactoperoxidase, no oxygen transfer to oral bacterial cells takes place, and no oral bacteria inactivation is accomplished.
Claim 4
Dependent Claim
9 words
The composition of claim 1 which includes a carbohydrase.
Claim 5
Dependent Claim
11 words
The composition of claim 3 in which said carbohydrase is amyloglucosidase.
Claim 6
Dependent Claim
27 words
The composition of claim 3 in which the amount by weight of said carbohydrase is from about 1 to about 8 times the amount of glucose hydrase.
Claim 7
Dependent Claim
29 words
The method of cleaning a dental surface and suppressing the formation of dental plaque thereon which comprises applying to said dental surface an enzymatic dentifrice, according to claim 1.
Claim 8
Dependent Claim
29 words
The method of cleaning a dental surface and suppressing the formation of dental plaque thereon which comprises applying to said dental surface an enzymatic dentifrice according to claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-10 | 1983-06-11 | 1983-12-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-10 | 1987-06-11 | 1987-12-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-10 | 1991-06-11 | 1991-12-11 | $7700.00 | Window Closed / Lapsed |