Patent US4604407A successfully refreshed from Google Patents.
US4604407A
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US
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Hydroxamates
Assignee: ER Squibb and Sons LLC
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Filing: 1985-04-04
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Granted: 1986-08-05
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Expires: 2005-04-04
Abstract
Abstract Hydroxamates are provided having the structure ##STR1## wherein R 1 is hydrogen, lower alkyl, aryl, lower alkenyl, cycloalkenyl, aralkyl, or ##STR2## wherein n is 1 to 4 and X is hydroxy, alkoxy, amino, C 1 -C 4 -alkylamino or C 1 -C 4 -dialkylamino. R 2 is hydrogen or lower alkyl; and R 3 is C 1 -C 20 alkyl or C 3 -C 20 alkenyl, aryl, aryl-alkyl, cycloalkyl, aryl-alkenyl, lower alkoxy, lower alkenyloxy, aryl-alkoxy or cycloalkyloxy, and m is 0 to 5. These compounds are useful as inhibitors of Δ 5 -lipoxygenase and as such are useful as antiallergy agents.
Inventors
- 👤 Martin F. Haslanger
- 👤 Donald S. Karanewsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 19:31
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/21; A61K31/215; A61P; A61P37/00; A61P37/08
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
43 words
A compound having the structure ##STR42## wherein m is 1 to 5, R 1 is lower alkyl, phenylalkyl or phenyl, R 2 is H or lower alkyl; and R 3 is cycloalkyl, phenyl or biphenyl, all of the above hydrocarbon groups being unsubstituted.
Claim 2
Dependent Claim
43 words
A compound having the structure ##STR42## wherein m is 1 to 5, R 1 is lower alkyl, phenylalkyl or phenyl, R 2 is H or lower alkyl; and R 3 is cycloalkyl, phenyl or biphenyl, all of the above hydrocarbon groups being unsubstituted.
Claim 3
Dependent Claim
27 words
The compound as defined in claim 1 wherein R 1 is CH 3 , t-C 4 H 9 , C 5 H 11 , phenyl or benzyl.
Claim 4
Dependent Claim
33 words
The compound as defined in claim 1 wherein R 1 is phenyl or phenylalkyl, R 2 is H, and R 3 is phenyl, biphenyl, or cycloalkyl and m is 1, 2 or 3.
Claim 5
Dependent Claim
12 words
The compound as defined in claim 1 having the name N-hydroxy-N-methyl [1,1'-biphenylyl]-4-acetamide.
Claim 6
Dependent Claim
11 words
The compound as defined in claim 1 having the name N-(1,1'-dimethylethyl)-N-hydroxy[1,1'-biphenylyl]-4-acetamide.
Claim 7
Dependent Claim
11 words
The compound as defined in claim 1 having the name N-hydroxy-N-phenylbenzenebutanamide.
Claim 8
Dependent Claim
12 words
The compound as defined in claim 1 having the name N-hydroxy-N-(phenylmethyl)cyclohexane acetamide.
Claim 9
Dependent Claim
11 words
The compound as defined in claim 1 having the name N-hydroxy-N-(phenylmethyl)benzenebutanamide.
Claim 10
Dependent Claim
11 words
The compound as defined in claim 1 having the name N-hydroxy-N-pentylbenzenebutanamide.
Claim 11
Dependent Claim
34 words
A composition for inhibiting allergic conditions in a mammalian species, comprising an effective amount of a compound as defined in claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier thereof.
Claim 12
Dependent Claim
35 words
A method of inhibiting Δ 5 -lipoxygenase which comprises administering to the circulatory system of a mammalian host an effective amount of a compound as defined in claim 1 or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
26 words
The method as defined in claim 11 wherein said compound is administered in an amount within the range of from about 1 to about 100 mg/kg.
Claim 14
Dependent Claim
38 words
A method for treating asthma in a mammalian species in need of such treatment, which comprises administering to a mammalian host an effective amount of a compound as defined in claim 1 or a pharmaceutically acceptable salt thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-04 | 1990-02-03 | 1990-08-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-04 | 1994-02-03 | 1994-08-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-04 | 1998-02-03 | 1998-08-05 | $7700.00 | Window Closed / Lapsed |