US4098903A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anti-hypertensive compounds
Assignee: Research Corp
•
Filing: 1976-06-01
•
Granted: 1978-07-04
•
Expires: 1996-06-01
Abstract
Abstract The subject invention is directed to compounds having the formula: ##STR1## wherein R 1 and R 2 are H, alkyl or combinations thereof, R 3 and R 4 are H, halogen, amino, alkylamino, alkoxy, alkyl, OH, O, NO 2 or combinations thereof, and X is CH or N, which compounds are useful as anti-hypertensive agents.
Inventors
- 👤 Kenneth R. Fountain
- 👤 Horst Kehl
- 👤 Terry Early
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 23:39
CPC Classifications
C; C07; C07D; C07D261/00; C07D261/02; C07D261/06; C07D261/10; C07D261/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
65 words
Compounds having the structure: ##STR11## wherein R 3 and R 4 are selected from the group consisting of hydrogen, halogen, amino, C 1 --C 7 alkylamino, C 1 --C 7 alkylamino, C 1 --C 7 alkyl, C 1 -C 7 alkoxy, hydroxyl, phenyl, NHOH, and nitro, with the proviso that only one of R 3 and R 4 is hydrogen, or pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
65 words
Compounds having the structure: ##STR11## wherein R 3 and R 4 are selected from the group consisting of hydrogen, halogen, amino, C 1 --C 7 alkylamino, C 1 --C 7 alkylamino, C 1 --C 7 alkyl, C 1 -C 7 alkoxy, hydroxyl, phenyl, NHOH, and nitro, with the proviso that only one of R 3 and R 4 is hydrogen, or pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
24 words
The compounds of claim 1, wherein R 4 is hydrogen and R 3 is selected from the group consisting of chloro, fluoro and bromo.
Claim 4
Dependent Claim
15 words
The compounds of claim 1, wherein each of R 3 and R 4 is methoxy.
Claim 5
Dependent Claim
76 words
A composition for use as an anti-hypertensive, consisting essentially of an anti-hypertensively effective amount of a compound having the structure: ##STR12## wherein R 3 and R 4 are selected from the group consisting of hydrogen, halogen, amino, C 1 -C 7 alkylamino, C 1 -C 7 alkyl, C 1 -C 7 alkoxy, hydroxyl, phenyl, NHOH, and nitro, with the proviso that only one of R 3 and R 4 is hydrogen, and a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
76 words
A composition for use as an anti-hypertensive, consisting essentially of an anti-hypertensively effective amount of a compound having the structure: ##STR12## wherein R 3 and R 4 are selected from the group consisting of hydrogen, halogen, amino, C 1 -C 7 alkylamino, C 1 -C 7 alkyl, C 1 -C 7 alkoxy, hydroxyl, phenyl, NHOH, and nitro, with the proviso that only one of R 3 and R 4 is hydrogen, and a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
30 words
A method for treating hypertensive crisis in warm blooded animals comprising administering to a warm blooded animal in need thereof an anti-hypertensively effective amount of the composition of claim 4.
References Cited (Backward Citations)
US3857946A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-03 | 1982-01-02 | 1982-07-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-03 | 1986-01-02 | 1986-07-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-03 | 1990-01-02 | 1990-07-04 | $7700.00 | Window Closed / Lapsed |