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US4599338A
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Antimigraine 8-[3-(4-aminocarbonyl piperazino and piperidino) propyl[xanthines
Assignee: Institut Servier de Medecine Translationnelle SARL
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Filing: 1985-01-16
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Granted: 1986-07-08
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Expires: 2005-01-16
Abstract
Abstract Xanthine compounds of the formula: ##STR1## in which: R 1 is hydrogen or (C 1 -C 5 ) alkyl; R 2 is hydrogen, (C 1 -C 5 ) alkyl optionally having a double bond, or benzyl; R 3 is hydrogen or methyl; A is (CH 2 ) n , in which n is an integer from 1 to 4, optionally substituted, when n is higher than 1, by hydroxy; X is nitrogen or ##STR2## and the substituents R are each (C 1 -C 5 ) alkyl or they form together a polymethylene chain from C 4 to C 6 , optionally containing an oxygen or a sulfur atom. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of migraine and asthenia.
Inventors
- 👤 Gilbert Regnier
- 👤 Claude Guillonneau
- 👤 Jacques Duhault
- 👤 Francois Roman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 21:45
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/16; C07D295/20; C07D295/215; A; A61; A61P; A61P25/00; A61P25/04; A61P43/00; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/56; C07D211/58; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08; C07D473/10; C07D473/12
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
179 words
A compound selected from the group consisting of xanthine compounds of the formula: ##STR12## in which: R 1 is selected from the group consisting of hydrogen and (C 1 -C 5 ) alkyl, in straight and branched chain; R 2 is selected from the group consisting of hydrogen, (C 1 -C 5 ) alkyl radicals in straight and branched chain and these radicals having a double bond, and benzyl R 3 is selected from the group consisting of hydrogen and methyl; A is selected from the group consisting of polymethylene chains (CH 2 ) n in which n is an integer from 1 to 4 inclusive, and such chains substituted, when n is higher than 1, by hydroxy; X is selected from the group consisting of nitrogen and ##STR13## the substituents R are each selected from the group consisting of alkyl radicals having from 1 to 5 carbon atoms inclusive or are joined together in order to form with the nitrogen atom to which they are bonded a piperidino or morpholino radical; and, physiologically tolerable acid addition salts thereof.
Claim 2
Dependent Claim
179 words
A compound selected from the group consisting of xanthine compounds of the formula: ##STR12## in which: R 1 is selected from the group consisting of hydrogen and (C 1 -C 5 ) alkyl, in straight and branched chain; R 2 is selected from the group consisting of hydrogen, (C 1 -C 5 ) alkyl radicals in straight and branched chain and these radicals having a double bond, and benzyl R 3 is selected from the group consisting of hydrogen and methyl; A is selected from the group consisting of polymethylene chains (CH 2 ) n in which n is an integer from 1 to 4 inclusive, and such chains substituted, when n is higher than 1, by hydroxy; X is selected from the group consisting of nitrogen and ##STR13## the substituents R are each selected from the group consisting of alkyl radicals having from 1 to 5 carbon atoms inclusive or are joined together in order to form with the nitrogen atom to which they are bonded a piperidino or morpholino radical; and, physiologically tolerable acid addition salts thereof.
Claim 3
Dependent Claim
9 words
A compound of claim 1 which is: 1,3,7-trimethyl-8-[3-(4-diethylamino-carbonyl piperazino)propyl]xanthine.
Claim 4
Dependent Claim
10 words
A compound of claim 1 which is: 1,7-dimethyl-3 isobutyl-8-[3-(4-diethylamino-carbonyl piperazino)propyl]xanthine.
Claim 5
Dependent Claim
9 words
A compound of claim 1 which is: 1,3,7-trimethyl-8-[3-(4-diethylamino-carbonylamino piperidino)propyl]xanthine.
Claim 6
Dependent Claim
21 words
Pharmaceutical compositions suitable for treating migraine containing as active ingredient a compound of claim 1 together with a suitable pharmaceutical carrier.
Claim 7
Dependent Claim
39 words
A method for treating a living animal body afflicted with migraine comprising the step of administering to the said living animal an amount of a compound of claim 1 which is effective for the alleviation of the said condition.
Claim 8
Dependent Claim
8 words
A compound of claim 1 which is: 1,3,7-trimethyl-8-[3-(4-piperidinocarbonylpiperazino)-propyl]-xanthine.
Claim 9
Dependent Claim
8 words
A compound of claim 1 which is: 1,3,7-trimethyl-8-[3-(4-morpholinocarbonylaminopiperazino)-propyl]-xanthine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-07 | 1990-01-06 | 1990-07-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-07 | 1994-01-06 | 1994-07-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-07 | 1998-01-06 | 1998-07-08 | $7700.00 | Window Closed / Lapsed |