US4284633A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Derivatives of xanthine
Assignee: Roche Diagnostics GmbH
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Filing: 1980-05-12
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Granted: 1981-08-18
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Expires: 2000-05-12
Abstract
Abstract The present invention provides xanthine derivatives of the general formula: <IMAGE> wherein one of the symbols R1 and R2 stands for a methyl radical and the other for a radical of the general formula: <IMAGE> wherein R3 is a hydrogen atom or an acyl radical; and the pharmacologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them and is also concerned with the use thereof for the preparation of pharmaceutical compositions for the treatment of allergies.
Inventors
- 👤 Walter-Gunar Friebe
- 👤 Max Thiel
- 👤 Wolfgang Kampe
- 👤 Otto-Henning Wilhelms
- 👤 Androniki Roesch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 10:54
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08; A; A61; A61P; A61P11/00; A61P11/08; A61P37/00; A61P37/08; C07D473/10
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
133 words
A xanthine derivative of the formula ##STR7## in which one of R 1 and R 2 is a methyl radical and the other a radical of the formula ##STR8## R 3 is a hydrogen atom or a lower alkanoyl radical containing up to 8 carbon atoms and which can be substituted by halogen, phenyl or naphthyl, an alkenoyl radical containing up to 8 carbon atoms which can be substituted by phenyl or naphthyl, a phenyl- or alkyl-sulphonyl radical, or a C 3 -C 7 -cycloalkylcarbonyl, furancarbonyl, thiophenecarbonyl, pyridinocarbonyl or benzoyl radical which can be substituted by halogen, hydroxyl, C 1 -C 8 -alkyl, lower C 1 -C 8 -alkoxy, C 1 -C 8 -alkoxycarbonyl, C 1 -C 8 -alkanoyloxy, carboxyl, nitro, amino, nitrilo, trifluoromethyl, carbamoyl or benzyl, or a pharmacologically acceptable salt thereof.
Claim 2
Dependent Claim
133 words
A xanthine derivative of the formula ##STR7## in which one of R 1 and R 2 is a methyl radical and the other a radical of the formula ##STR8## R 3 is a hydrogen atom or a lower alkanoyl radical containing up to 8 carbon atoms and which can be substituted by halogen, phenyl or naphthyl, an alkenoyl radical containing up to 8 carbon atoms which can be substituted by phenyl or naphthyl, a phenyl- or alkyl-sulphonyl radical, or a C 3 -C 7 -cycloalkylcarbonyl, furancarbonyl, thiophenecarbonyl, pyridinocarbonyl or benzoyl radical which can be substituted by halogen, hydroxyl, C 1 -C 8 -alkyl, lower C 1 -C 8 -alkoxy, C 1 -C 8 -alkoxycarbonyl, C 1 -C 8 -alkanoyloxy, carboxyl, nitro, amino, nitrilo, trifluoromethyl, carbamoyl or benzyl, or a pharmacologically acceptable salt thereof.
Claim 3
Dependent Claim
16 words
A xanthine derivative or salt thereof according to claim 1, in which said derivative is 7-[3-(4-acetamidopiperidino)-propyl]-theophylline.
Claim 4
Dependent Claim
16 words
A xanthine derivative or salt thereof according to claim 1, in which said derivative is 7-{3-[4-(2-methylbenzamido)-piperidino]-propyl}-theophylline.
Claim 5
Dependent Claim
16 words
A xanthine derivative or salt thereof according to claim 1, in which said derivative is 7-[3-(4-phenylacetamidopiperidino)-propyl]-theophylline.
Claim 6
Dependent Claim
16 words
A xanthine derivative or salt thereof according to claim 1, in which said derivative is 7-{3-[4-(2-hydroxybenzamido)-piperidino]-propyl}-theophylline.
Claim 7
Dependent Claim
17 words
A xanthine derivative or salt thereof according to claim 1, in which said derivative is 7-{- 3-[4-(thiophene-2-carboxamido)-piperidino]-propyl}-theophylline.
Claim 8
Dependent Claim
28 words
An anti-allergic composition of matter comprising an anti-allergically effective amount of a xanthine derivative or salt thereof according to claim 1 in admixture with a pharmaceutically acceptable diluent.
Claim 9
Dependent Claim
30 words
A method of inhibiting an allergic response in a patient comprising administering to such patient an anti-allergically effective amount of a xanthine derivative or salt thereof according to claim 1.
Claim 10
Dependent Claim
17 words
The method according to claim 8 in which said derivative is 7-[3-(4-acetamidopiperidino)-propyl]-theophylline, 7-{3-[4-(2-methylbenzamido)-piperidino]-propyl}-theophylline, 7-[3-(4-phenylacetamidopiperidino)-propyl]-theophylline, 7-{3-[4-(2-hydroxybenzamido)-piperidino]-propyl}-theophylline, or 7-{3-[4-(thiophene-2-carboxamido)-piperidino]-propyl}-theophylline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-17 | 1985-02-16 | 1985-08-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-17 | 1989-02-16 | 1989-08-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-17 | 1993-02-16 | 1993-08-18 | $7700.00 | Window Closed / Lapsed |