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Patent US4596464A successfully refreshed from Google Patents.
US4596464A
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Screening method for red cell abnormality
Assignee: Ortho Clinical Diagnostics Inc
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Filing: 1983-12-02
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Granted: 1986-06-24
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Expires: 2003-12-02
Abstract
Abstract Red cell samples are passed through a zone of focused illumination, and a scatter vs. time pulse is obtained for each. Each pulse is analyzed for pulse width, pulse area, and pulse shape. These parameters are respectively collected, and three coefficients of variation are obtained for each such collection. In addition to these three abnormality factors, the mean of the pulse shape collection constitutes a fourth. The four are respectively subject to statistical criteria, and are combined in predetermined fashion for a single red cell morphology index.
Inventors
- 👤 Robert A. Hoffman
- 👤 Richard L. Kane
- 👤 Brandon J. Price
- 👤 Russell J. Gershman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 15:09
CPC Classifications
G; G01; G01N; G01N15/00; G01N15/10; G01N15/14; G01N15/1456; G01N15/01; G01N2015/012
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
163 words
In an optical cell analysis system, a method for screening cells from a sample of cells for red blood cell abnormalities comprising the steps of: (a) passing the cells of said sample, one at a time in sequence, through a zone of focused illumination, (b) for each of said cells, developing a pulse waveform representative of predetermined light scatter from said zone; (c) developing respective data collections, based on given samples of cells, of pulse widths and pulse areas; (d) developing, for each cell, as an indicium of pulse shape, the ratio of pulse width to pulse peak, and developing a collection of pulse shape indicia; (e) computing respective coefficients of variation, of said pulse width, pulse area, and pulse shape indicia collections; (f) combining said coefficients of variation in accordance with a predetermined function, thereby producing a red cell abnormality index; (g) evaluating said red cell abnormality index relative to predetermined standards to identify samples having significant degrees of red cell abnormality.
Claim 2
Dependent Claim
163 words
In an optical cell analysis system, a method for screening cells from a sample of cells for red blood cell abnormalities comprising the steps of: (a) passing the cells of said sample, one at a time in sequence, through a zone of focused illumination, (b) for each of said cells, developing a pulse waveform representative of predetermined light scatter from said zone; (c) developing respective data collections, based on given samples of cells, of pulse widths and pulse areas; (d) developing, for each cell, as an indicium of pulse shape, the ratio of pulse width to pulse peak, and developing a collection of pulse shape indicia; (e) computing respective coefficients of variation, of said pulse width, pulse area, and pulse shape indicia collections; (f) combining said coefficients of variation in accordance with a predetermined function, thereby producing a red cell abnormality index; (g) evaluating said red cell abnormality index relative to predetermined standards to identify samples having significant degrees of red cell abnormality.
Claim 3
Dependent Claim
32 words
A method as described in claim 1 wherein said step of combining further comprises identifying the mean of said collection of pulse shape indicia, and combining it with said coefficients of variation.
Claim 4
Dependent Claim
41 words
A method as described in claim 2 wherein said step of combining coefficients of variation comprises first developing an index of abnormality for each said coefficient, and then for combining those individual indices which fall outside a select range of acceptability.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-06-23 | 1989-12-23 | 1990-06-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-06-23 | 1993-12-23 | 1994-06-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-06-23 | 1997-12-23 | 1998-06-24 | $7700.00 | Window Closed / Lapsed |