US3686486A — Apparatus for obtaining statistical hematological…

Claim 1

Independent Claim 83 words

A method of analyzing an unknown sample of blood which comprises the steps of: measuring by electrical means a sample of normal blood and thereby deriving a statistical hematological index of that sample of normal blood, storing a first electrical quantity representative of this index, measuring by the same electrical means an unknown blood sample and thereby deriving the same hematological index for the unknown blood, obtaining second electrical quantity representative of the latter index, and comparing the two electrical quantities by division.

Claim 2

Independent Claim 83 words

A method of analyzing an unknown sample of blood which comprises the steps of: measuring by electrical means a sample of normal blood and thereby deriving a statistical hematological index of that sample of normal blood, storing a first electrical quantity representative of this index, measuring by the same electrical means an unknown blood sample and thereby deriving the same hematological index for the unknown blood, obtaining second electrical quantity representative of the latter index, and comparing the two electrical quantities by division.

Claim 3

Dependent Claim 20 words

The method as claimed in claim 1 in which a plurality of different hematological indices are measured for each sample.

Claim 4

Dependent Claim 51 words

The method as claimed in claim 1 in which the index is S.K. and said steps of deriving the index of both samples include steps for deriving the S.K. index by electrically obtaining the factors for and thereupon electrically solving the formula: S.K. 2 (Q75 - 2Q50 + Q25/Q75 - Q25).

Claim 5

Dependent Claim 49 words

The method as claimed in claim 1 in which the index is C.Q.V. and said steps of deriving the index of both samples includes the steps for deriving the C.Q.V. index by electrically obtaining the factors for and thereupon electrically solving the formula: C.Q.V. (Q75 - Q25/Q75 + Q25).100

Claim 6

Dependent Claim 45 words

The method as claimed in claim 1 in which the index is M.C.V. and said steps of deriving the index of both samples includes the stEp of deriving the M.C.V. index by electrically obtaining the factors for and thereupon electrically solving the value of M.C.V.

Claim 7

Dependent Claim 70 words

The method as claimed in claim 1 in which said step of storing the first derived electrical quantity includes the steps of applying that quantity to null circuit means, which also receives a signal output level from potentiometer means, and setting the signal output level to a storage value position of the potentiometer means which balances the null circuit means, such storage value thereby representing the first derived electrical quantity.

Claim 8

Dependent Claim 60 words

The method as claimed in claim 2 in which the indices include at least two of C.Q.V., S.K. and M.C.V. and the steps of deriving the index of both samples include the steps of deriving at least two of the C.Q.V., S.K. and M.C.V. indices by electrically obtaining formula factors for said indicies and thereupon electrically solving the formulas thereof.

Claim 9

Dependent Claim 126 words

Apparatus for obtaining the C.Q.V. of blood from a sample of blood which has been passed through a device which provides a source of electrical pulses respectively having amplitudes substantially proportional to the blood cells producing the same, comprising A. a 75th percentile producing circuit having an input for receiving the blood cell representing pulses and an output, B. a 25th percentile producing circuit having an input for receiving the blood cell representing pulses and an output, C. algebraic summing network means connected to the outputs of said circuits for providing a voltage representing the sum and difference of the respective outputs of the circuits, and D. a dividing circuit for dividing the difference by the sum to obtain an output voltage proportional to the C.Q.V.

Claim 10

Dependent Claim 126 words

Apparatus for obtaining the C.Q.V. of blood from a sample of blood which has been passed through a device which provides a source of electrical pulses respectively having amplitudes substantially proportional to the blood cells producing the same, comprising A. a 75th percentile producing circuit having an input for receiving the blood cell representing pulses and an output, B. a 25th percentile producing circuit having an input for receiving the blood cell representing pulses and an output, C. algebraic summing network means connected to the outputs of said circuits for providing a voltage representing the sum and difference of the respective outputs of the circuits, and D. a dividing circuit for dividing the difference by the sum to obtain an output voltage proportional to the C.Q.V.

Claim 11

Dependent Claim 30 words

The apparatus as claimed in claim 8 further including means are provided for storing the output voltage, and means for comparing a subsequently obtained C.Q.V. voltage with the one stored.

Claim 12

Dependent Claim 42 words

The apparatus as claimed in claim 9 in which said means for comparing includes a second dividing circuit connected to said storing means and to said first-mentioned dividing circuit and having an output proportional to the ratio between the two C.Q.V. voltages.

Claim 13

Dependent Claim 51 words

The apparatus as claimed in claim 9 in which said means for storing includes potentiometer means, and null circuit means interposed between said dividing circuit and said potentiometer means, whereby setting said potentiometer means to a storage value position equal to the proportional output voltage will balance said null circuit means.

Claim 14

Dependent Claim 107 words

Apparatus for analysis of statistical hematological indices which comprises: A. means for obtaining particle pulses related to a first blood sample, said pulses having amplitudes proportional respectively to the sizes of the particles which produced the same, B. means connected to said obtaining means for deriving electrically from the particle pulses a plurality of statistical indices from said particles, C. means coupled to said deriving means for storing each of said indices, and D. means coupled to both said storing means and said deriving means for comparing said stored indices respectively with like indices obtained by way of said deriving means and related to another blood sample.

Claim 15

Dependent Claim 107 words

Apparatus for analysis of statistical hematological indices which comprises: A. means for obtaining particle pulses related to a first blood sample, said pulses having amplitudes proportional respectively to the sizes of the particles which produced the same, B. means connected to said obtaining means for deriving electrically from the particle pulses a plurality of statistical indices from said particles, C. means coupled to said deriving means for storing each of said indices, and D. means coupled to both said storing means and said deriving means for comparing said stored indices respectively with like indices obtained by way of said deriving means and related to another blood sample.

Claim 16

Dependent Claim 19 words

The apparatus as claimed in claim 12 in which said comparing means comprise dividing circuit means providing ratio outputs.

Claim 17

Dependent Claim 25 words

The apparatus as claimed in claim 12 in which said indices include C.Q.V. and said deriving means includes electrical means for deriving the C.Q.V. index.

Claim 18

Dependent Claim 25 words

The apparatus as claimed in claim 12 in which said indices include M.C.V. and said deriving means includes electrical means for deriving the C.Q.V. index.

Claim 19

Dependent Claim 25 words

The apparatus as claimed in claim 12 in which said indices include S.K. and said deriving means includes electrical means for deriving the C.Q.V. index.

Claim 20

Dependent Claim 50 words

The apparatus as claimed in claim 12 in which said means For storing includes potentiometer means, and null circuit means interposed between said deriving means and said potentiometer means, whereby setting said potentiometer means to a storage value position equal to a derived index will balance said null circuit means.

Claim 21

Dependent Claim 143 words

Apparatus for obtaining the S.K. index of blood from a sample of blood which has been passed through a device which provides a source of electrical pulses respectively having amplitudes substantially proportional to the blood cells producing the same which comprises: A. 25th, 50th and 75th percentile producing circuits having a common input for receiving the blood cell representing electrical pulses and separate outputs, B. a computer circuit performing the operation of adding the outputs of the 25th and 75th percentile circuits and subtracting twice the output of the 50th percentile circuit, C. an algebraic summing circuit having an output equal to the difference between the outputs of the 25th and 75th percentile circuits, D. means for dividing the computer circuit output by the algebraic summing circuit output and multiplying the same by two to obtain a signal proportional to the S.K. index.

Claim 22

Dependent Claim 143 words

Apparatus for obtaining the S.K. index of blood from a sample of blood which has been passed through a device which provides a source of electrical pulses respectively having amplitudes substantially proportional to the blood cells producing the same which comprises: A. 25th, 50th and 75th percentile producing circuits having a common input for receiving the blood cell representing electrical pulses and separate outputs, B. a computer circuit performing the operation of adding the outputs of the 25th and 75th percentile circuits and subtracting twice the output of the 50th percentile circuit, C. an algebraic summing circuit having an output equal to the difference between the outputs of the 25th and 75th percentile circuits, D. means for dividing the computer circuit output by the algebraic summing circuit output and multiplying the same by two to obtain a signal proportional to the S.K. index.

Claim 23

Dependent Claim 41 words

The apparatus as claimed in claim 18 further including means for storing the last-mentioned signal, and means for comparing the stored signal with a S.K. index signal obtained by said apparatus according to claim 15, but from another sample of blood.

Claim 24

Dependent Claim 42 words

The apparatus as claimed in claim 19 in which said means for comparing includes a dividing circuit connected to said storing means and to said dividing and multiplying means and having an output proportional to the ratio between the two S.K. signals.

Claim 25

Dependent Claim 53 words

The apparatus as claimed in claim 19 in which said means for storing includes potentiometer means, and null circuit means interposed between said dividing and multiplying means and said potentiometer means, whereby setting said potentiometer means to a storage value position equal to the index proportional signal will balance said null circuit means.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1975-08-22	1976-02-21	1976-08-22	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1979-08-22	1980-02-21	1980-08-22	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1983-08-22	1984-02-21	1984-08-22	$7700.00	Window Closed / Lapsed

Apparatus for obtaining statistical hematological indices and analyzing same and method

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