US4588831A
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Platinum complex compounds of substituted 5,8-dihydroxyl-1,4-naphthoquinone, and process for their production and use
Assignee: NATEC INSTITUT fur NATURWISSENSCHAFTLICH-TECHNISCHE DIENSTE BEHRINGSTRASSE 24 GmbH
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Filing: 1984-11-09
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Granted: 1986-05-13
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Expires: 2004-11-09
Abstract
Abstract The invention relates to platinum complexes of the following general formula: ##STR1## wherein R 1 and R 2 represent alkyl radicals with 1 to 18 carbon atoms, or R 1 or R 2 represent a hydrogen atom and R 2 or R 1 can represent an alkyl radical or a ##STR2## in which R 3 is a hydrogen atom or the ##STR3## radical or an acyl radical, and x=1 or 2. These compounds can be produced by reaction of an alcohol solution of a 5,8-dihydroxyl-1,4-naphthoquinone of the following formula: ##STR4## in which the substituents R 1 and R 2 have the aforementioned meanings, in the presence of a concentrated aqueous ammonia solution, which adjusts the pH over 7, with K 2 PtCl 4 at room temperature. These platinum complex compounds are characterized by a good antitumor effect with low toxicity.
Inventors
- 👤 Angelos N. Sagredos
- 👤 Vassilios P. Papageorgiou
- 👤 Antonius S. Mellidis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 06:42
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
78 words
Platinum complex compounds of the general formula: ##STR17## wherein R 1 and R 2 can be identical or different, and represent an alkyl radical with 1 to 18 carbon atoms, or either R 1 or R 2 represent a hydrogen atom or R 2 or R 1 represents an alkyl radical with 1 to 18 carbon atoms, and ##STR18## wherein R 3 is a hydrogen atom or the: ##STR19## radical or an acyl radical, and x=1 or 2.
Claim 2
Dependent Claim
78 words
Platinum complex compounds of the general formula: ##STR17## wherein R 1 and R 2 can be identical or different, and represent an alkyl radical with 1 to 18 carbon atoms, or either R 1 or R 2 represent a hydrogen atom or R 2 or R 1 represents an alkyl radical with 1 to 18 carbon atoms, and ##STR18## wherein R 3 is a hydrogen atom or the: ##STR19## radical or an acyl radical, and x=1 or 2.
Claim 3
Dependent Claim
23 words
Platinum complex compounds as defined in claim 1, wherein R 1 and R 2 are alkyl radicals with 1 to 6 carbon atoms.
Claim 4
Dependent Claim
19 words
Platinum complex compounds as defined in claim 1 wherein the acyl radical R 3 is an angelic acid radical.
Claim 5
Dependent Claim
116 words
Process for the production of platinum complex compounds as defined in claim 1 wherein an alcoholic solution of a 5,8-dihydroxyl-1,4-naphthoquinone of the following formula is provided: ##STR20## wherein the substituents R 1 and R 2 (including R 3 ) have the aforementioned meanings, a pH value of over 7 is set by addition of concentrated aqueous ammonia solution and then is reacted with an aqueous solution of K 2 PtCl 4 at room temperature, and the reaction mixture is stirred for several hours continuously, and then the separated platinum complex compounds of the general formula I are filtered out and washed in sequence with water, acetone and, if desired, with an ether and finally are dried.
Claim 6
Dependent Claim
32 words
Process as defined in claim 4 wherein the reaction is carried out at a pH of 8 to 8.5 and essentially platinum complex compounds of the formula I with x=1 are obtained.
Claim 7
Dependent Claim
30 words
Process as defined in claim 4, wherein the reaction occurs at a pH of over 10, and then essentially platinum complex compounds of the formula I with x=2 are obtained.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-05-12 | 1989-11-11 | 1990-05-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-05-12 | 1993-11-11 | 1994-05-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-05-12 | 1997-11-11 | 1998-05-13 | $7700.00 | Window Closed / Lapsed |