US4283342A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Anticancer agents and methods of manufacture
Assignee: University of Delaware
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Filing: 1980-01-31
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Granted: 1981-08-11
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Expires: 2000-01-31
Abstract
Abstract A therapeutic metal coordination compound, particularly useful as an anticancer agent, which is the reaction product of a hydroxy quinone and a cisplatinum (II) compound substituted with chloro ligands and ammonia or derivatized ammonia ligands and the process for its manufacture.
Inventors
- 👤 Seymour Yolles
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 20:39
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/20; C07H15/24; C07H15/252; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; C07H23/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
125 words
A metal coordination compound comprising, as a therapeutic portion, (a) A multi-ring quinone having at least one hydroxy group in a ring fused to the quinone ring as ligand, (b) chelated at keto and hydroxy groups with the platinum metal (c) in a cis-dichloro platinum (II) compound having two platinum metal coordinate bonds each joined to a member of the group consisting of ammonia, mono-substituted ammonia and ammonia radicals connected one to the other by single valence bonds through adjacent carbons of a carbon ring compound, and (d) additional cis-dichloro platinum (II) compound not bonded to the hydroxy quinone but coordinated to said platinum which is bonded to said hydroxy quinone, and, as a non-therapeutic portion, (e) excess platinum in the form of tetrachloro-platinate anion.
Claim 2
Dependent Claim
125 words
A metal coordination compound comprising, as a therapeutic portion, (a) A multi-ring quinone having at least one hydroxy group in a ring fused to the quinone ring as ligand, (b) chelated at keto and hydroxy groups with the platinum metal (c) in a cis-dichloro platinum (II) compound having two platinum metal coordinate bonds each joined to a member of the group consisting of ammonia, mono-substituted ammonia and ammonia radicals connected one to the other by single valence bonds through adjacent carbons of a carbon ring compound, and (d) additional cis-dichloro platinum (II) compound not bonded to the hydroxy quinone but coordinated to said platinum which is bonded to said hydroxy quinone, and, as a non-therapeutic portion, (e) excess platinum in the form of tetrachloro-platinate anion.
Claim 3
Dependent Claim
24 words
A metal coordination compound according to claim 1 wherein said multi-ring quinone is doxorubicin and said cis-dichloro platinum (II) compound is cis-dichlorodiammine platinum (II).
Claim 4
Dependent Claim
22 words
A metal coordination compound according to claim 1 wherein said cis-dichloro platinum (II) compound is cis-dichloro 1, 2 -cyclohexane diamino platinum (II).
Claim 5
Dependent Claim
40 words
A metal coordination compound according to claim 1 wherein said cis-dichloro (II) compound has the general formula cis (RNH 2 ) 2 dichloro platinum (II) wherein R can be hydrogen or an alkyl group having 1 to 10 carbon atoms.
Claim 6
Dependent Claim
16 words
A metal coordination compound according to claim 4 wherein said cis-dichloro platinum (II) compound is cis.
Claim 7
Dependent Claim
29 words
A metal coordination compound according to claim 1 wherein said multi-ring quinone is a member of the group juglone, naphthazarin quinizarin, alizarin, and 8, 11 dihydroxy 5, 12 naphthacenedione.
Claim 8
Dependent Claim
91 words
The method of manufacturing a metal coordination compound of the composition of claim 1 comprising, in the sequence recited, mixing said multi-ring quinone with said cis-dichloro platinum II in a liquid heat sink comprising essentially a solvent for one of the reactants, ball milling said mixture with said liquid heat sink at room temperature in a hermetically sealed ceramic or glass jar for at least 12 hours using glass, ceramic or other non-metallic balls, filtering solids from said liquid heat sink and from the filtrate to recover said metal coordination compound.
Claim 9
Dependent Claim
31 words
The method of manufacturing a metal coordination compound according to claim 8 wherein said solvent is a member of the group dimethyl formamide, dimethyl acetamide, methylene chloride, methyl pyrolidone, hexamethyl phosphoramide.
Claim 10
Dependent Claim
54 words
The method of manufacturing a metal coordination compound according to claim 7 wherein said cis-dichloro platinum (II) compound is proportioned to said quinones as charged in the ratios of approximately 5:1 to 8:1 in mols for quinones having two hydroxy groups and approximately 3:1 to 5:1 in mols for quinones having one hydroxy group.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-10 | 1985-02-09 | 1985-08-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-10 | 1989-02-09 | 1989-08-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-10 | 1993-02-09 | 1993-08-11 | $7700.00 | Window Closed / Lapsed |